Table 2 Subgroup analyses on mortality
Studies | Patients, N | Relative Risk (95% CI) | P | Heterogeneity(P; I2) | |
|---|---|---|---|---|---|
Baseline APACHE II score | |||||
Both groups < 20 | 5 | 541 | 0.69 (0.45, 1.04) | 0.08 | 0.45; 0% |
Both groups ≥ 20 | 5 | 888 | 0.82 (0.66, 1.04) | 0.10 | 0.76; 0% |
One group ≥ 20 | 2 | 34 | 0.39 (0.15, 1.02) | 0.06 | 0.57; 0% |
SAPS II | 2 | 657 | 0.92 (0.73, 1.16) | 0.50 | 1.00; 0% |
Baseline age (years) | |||||
≤ 50 | 8 | 695 | 0.71 (0.48, 1.04) | 0.08 | 0.69; 0% |
> 50 | 7 | 1435 | 0.86 (0.73, 1.01) | 0.06 | 0.45; 0% |
Number of patients | |||||
< 20/group | 4 | 60 | 0.60 (0.21, 1.70) | 0.34 | 0.36; 7.34% |
≥ 20/group | 11 | 2070 | 0.84 (0.72, 0.98) | 0.03 | 0.72; 0% |
Publication year | |||||
Before 2010 | 8 | 465 | 0.71 (0.40, 1.27) | 0.25 | 0.47; 0% |
After 2010 | 7 | 1665 | 0.84 (0.72, 0.98) | 0.03 | 0.61; 0% |
Pathogen | |||||
Mostly Gram-negative | 11 | 1323 | 0.81 (0.68, 0.96) | 0.02 | 0.68; 0% |
Mix | 4 | 807 | 0.87 (0.52, 1.45) | 0.59 | 0.33; 12.27% |
Loading dose in prolonged infusion group | |||||
Yes | 13 | 2020 | 0.84 (0.72, 0.97) | 0.02 | 0.55; 0% |
No | 2 | 110 | 0.65 (0.24, 1.73) | 0.39 | 0.54; 0% |
Classification of antibiotics | |||||
Carbapenems | 4 | 907 | 0.90 (0.73, 1.10) | 0.30 | 0.58, 0% |
Cephalosporins | 3 | 128 | 0.79 (0.22, 2.89) | 0.73 | 0.14, 48.95% |
Penicillin | 5 | 463 | 0.61 (0.38, 0.98) | 0.04 | 0.93, 0% |