Table 1 Comparison of the two studies for bacterial meningitis initially or directly admitted to the ICU
From: Should initial ICU admission become a standard of care for acute bacterial meningitis ?
Direct ICU admission for bacterial meningitis | Chekrouni et al. [1] | Thy et al. [2] |
|---|---|---|
Design | Prospective cohort of community-acquired bacterial meningitis (MeninGene study) | Retrospective analysis of pneumococcal meningitis with sepsis (PMSI database) |
Country | Netherlands | France |
Date of inclusion | From 2006 to 2022 | From 2011 to 2020 |
Main characteristics | N = 2709 | N = 4052 |
Initial/direct ICU admission rate | 1369 (51%) | 2006 (50%) |
Median age (IQR), years | 61 (49–69) | 60 (49–70) |
Male sex | 737/1369 (54%) | 1141 (57%) |
S. pneumoniae | 1071/1369 (78%) | 100% |
Associated infection | ||
Endocarditis | 26/1312 (2%) | 139 (7%) |
Pneumonia | 141/1313 (11%) | 712 (36%) |
Complications | ||
Coma (GCS < 8) | 431/1360 (32%) | 1117 (56%) |
Focal neurological deficits | 362 of 1220 (30%) | 373 (19%) |
Seizures | 230/1313 (18%) | 231 (12%) |
Cranial nerve palsy / Brainstem failure | 97/1074 (9%) | 356 (18%) |
Vascular complications* | 244 (18%) | 150 (8%) |
Hydrocephalus | 72/1241 (6%) | 27 (1%) |
Organ failure on admission | ||
Cardiovascular failure on admission | 220/1272 (17%) | 1188 (59%) |
Respiratory failure on admission | 470/1300 (36%) | 1437 (72%) |
Outcomes | ||
In-hospital mortality | 304 (22%) | 533 (27%) |
Unfavorable outcome (GOS 2–4 or discharge to readaptation) | 339 (25%) | 337 (17%) |
Median ICU length of stay (IQR), days | 3 (2–8) | 7 (3–15) |
Median hospital length of stay (IQR), days | 15 (12–24) | 21 (13–37) |