Total effect estimation model | Direct effect estimation model | |||
---|---|---|---|---|
Variable | HR [95% CI] | P value | HR [95% CI] | P value |
Socioeconomic phenotype | 0.13 | 0.56 | ||
Phenotype A | Reference | Reference | ||
Phenotype B | 0.85 [0.65–1.12] | 0.94 [0.71–1.24] | ||
Phenotype C | 0.56 [0.34–0.93] | 0.69 [0.41–1.16] | ||
Phenotype D | 1.09 [0.78–1.51] | 0.98 [0.70–1.35] | ||
Phenotype E | 1.20 [0.73–1.96] | 1.24 [0.75–2.03] | ||
Age per 1 year increment | 1.04 [1.04–1.05] | < 0.001 | 1.03 [1.03–1.04] | < 0.001 |
Female sex | 0.63 [0.51–0.78] | <0 .001 | 0.83 [0.66–1.04] | 0.11 |
Alcohol or opiate use | 0.91 [0.70–1.18] | 0.47 | 0.89 [0.68–1.17] | 0.41 |
Charlson comorbidity index ≥ 1 | – | – | 1.34 [1.05–1.71] | 0.02 |
Admission SOFA score, per point | – | – | 1.22 [1.20–1.25] | < .001 |