Variables | Extensively-assisted weaning (n = 47) | Standard weaning (n = 47) | p-value | |
---|---|---|---|---|
Median [CI95%] | Median [CI95%] | HR or SHR [95%CI] | ||
Primary outcome | ||||
Time until successful extubation—Cox model—hrs. § | 172 [50–436] | 95 [47–232] | 0.88 [0.55–1.42] | 0.60 |
Secondary outcomes | ||||
Time to successful extubation—Fine and Gray model—hrs. §§ | 172 [50–436] | 95 [47–232] | 0.84 [0.53–1.34] | 0.47 |
Time to death—Fine and Gray model—hrs. §§ | 488 [346–NR] | 633 [321–NR] | 1.30 [0.58–2.93] | 0.53 |
Median [IQR] | Median [IQR] | Median difference [CI95%]* | p-value | |
---|---|---|---|---|
Invasive mechanical ventilation duration [IQR]—hrs. † | 129 [25–344] | 95 [22–285] | 5 [-37–68] | 0.73 |
Mechanical ventilation duration [IQR]—hrs. † | 187 [61–355] | 122 [46–321] | 25 [-42–97] | 0.34 |
Median ventilator-free days at day-28 [IQR]—day † | 16 [0–26] | 20 [0–26] | 0 [− 3–1] | 0.59 |
Median ventilator-free days at day-90 [IQR]—day † | 77 [0–88] | 82 [0–88] | 0 [− 2–1] | 0.72 |
Median ICU length of stay [IQR]—day † | 8 [4–18] | 9 [4–16] | 0 [− 3–3] | 0.84 |
Median hospital length of stay [IQR]—day † | 25 [15–47] | 26 [12–65] | 0 [− 10–8] | 0.94 |
No. (%) | No. (%) | Absolute rate difference [CI95%]* | p-value | |
---|---|---|---|---|
Rate of successful extubation on the first extubation attempt | 22 (47%) | 27 (57%) | − 11 [− 30 –11]% | 0.41 |
ICU mortality | 14 (30%) | 13 (28%) | 2 [− 17–21]% | 1 |
Day-28 mortality | 15 (32%) | 12 (26%) | 6 [− 13–23]% | 0.65 |
Day-90 mortality | 19 (40%) | 15 (32%) | 8 [− 11–28]% | 0.52 |
Rate of patients experiencing reintubation among extubated patients | 18/41 (44%) | 17/44 (39%) | 5 [− 16–26]% | 0.66 |