COVID-19 associated pulmonary aspergillosis in critically-ill patients: a prospective multicenter study in the era of Delta and Omicron variants

Annals of Intensive Care

Table 4 Predictors of CAPA occurrence by univariable and multivariable logistic regression models in critically ill patients with COVID-19: results after missing data imputation (n = 566)

Factor	Univariable Analysis		p-value	Multivariable Analysis
Factor	OR	95% CI	p-value	aOR	95% CI	p-value
Blood leukocytes, G/L	1.02	(1.004;1.05)	0.018
SAPS II score	1.02	(1.001;1.05)	0.047	1.03	(1.003;1.05)	0.028
Age, years	1.00	(0.98;1.03)	0.740
Gender, females	0.74	(0.32;1.70)	0.473
SOFA score	1.13	(1.01;1.26)	0.028
Serum urea level, mM	1.01	(0.99;1.03)	0.368
First symptoms—ICU admission, days	1.03	(1.001;1.06)	0.042	1.03	(0.997;1.06)	0.077
Invasive mechanical ventilation	2.04	(0.94;4.42)	0.073
Immunosuppression	2.36	(1.116;5.01)	0.025	2.65	(1.13;6.20)	0.025
SARS-CoV-2 variant
Omicron (ref)	1 (ref)			1 (ref)
Delta	1.63	(0.74;3.60)	0.225	2.72	(1.12;6.58)	0.027

aOR (CI 95%): adjusted Odds Ratio (95% confidence interval)
CAPA COVID-19-associated pulmonary aspergillosis, ICU intensive care unit, SAPS simplified acute physiology score; SOFA Sequential Organ Failure Assessment
p-values come from multivariable logistic regression models
Bolded p-values are significant at the p < 0.05 level