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  1. Research

    Circulating bile acids predict outcome in critically ill patients

    Jaundice and cholestatic hepatic dysfunction are frequent findings in critically ill patients associated with increased mortality. Cholestasis in critically ill patients is closely associated with stimulation ...

    Thomas Horvatits, Andreas Drolz, Karoline Rutter, Kevin Roedl, Lies Langouche, Greet Van den Berghe, Günter Fauler, Brigitte Meyer, Martin Hülsmann, Gottfried Heinz, Michael Trauner and Valentin Fuhrmann

    Annals of Intensive Care 2017 7:48

    Published on: 2 May 2017

  2. Research

    Seawater drowning-associated pneumonia: a 10-year descriptive cohort in intensive care unit

    Pneumonia is one of the major complications of drowning, but the optimal empirical antibiotic treatment is not clearly defined. Multidrug-resistant (MDR) bacteria and fungi have been identified in a recent se...

    Alexandre Robert, Pierre-Éric Danin, Hervé Quintard, Nicolas Degand, Nihal Martis, Denis Doyen, Céline Pulcini, Raymond Ruimy, Carole Ichai, Gilles Bernardin and Jean Dellamonica

    Annals of Intensive Care 2017 7:45

    Published on: 26 April 2017

  3. Research

    Outcome of patients with septic shock and high-dose vasopressor therapy

    Despite the dissemination of international guidelines, mortality from septic shock remains high. Norepinephrine is recommended as first-line vasopressor therapy with a target mean arterial pressure of 65 mmHg....

    Thomas Auchet, Marie-Alix Regnier, Nicolas Girerd and Bruno Levy

    Annals of Intensive Care 2017 7:43

    Published on: 20 April 2017

  4. Research

    The protective association of endogenous immunoglobulins against sepsis mortality is restricted to patients with moderate organ failure

    Pre-evaluation of endogenous immunoglobulin levels is a potential strategy to improve the results of intravenous immunoglobulins in sepsis, but more work has to be done to identify those patients who could ben...

    Ignacio Martin-Loeches, Arturo Muriel-Bombín, Ricard Ferrer, Antonio Artigas, Jordi Sole-Violan, Leonardo Lorente, David Andaluz-Ojeda, Adriele Prina-Mello, Ruben Herrán-Monge, Borja Suberviola, Ana Rodriguez-Fernandez, Pedro Merino, Ana M. Loza, Pablo Garcia-Olivares, Eduardo Anton, Eduardo Tamayo…

    Annals of Intensive Care 2017 7:44

    Published on: 20 April 2017

  5. Editorial

    Protocols for the obvious: Where does it start, and stop?

    Protocols can be helpful in specific situations and may have show benefits in clinical trials. So-called evidence based protocols and checklists frequently remind clinicians to do the obvious, but may also co...

    Armand R. J. Girbes and Paul E. Marik

    Annals of Intensive Care 2017 7:42

    Published on: 14 April 2017

  6. Research

    Patients with ANCA-associated vasculitis admitted to the intensive care unit with acute vasculitis manifestations: a retrospective and comparative multicentric study

    Data for ANCA-associated vasculitis (AAV) patients requiring intensive care are scarce.

    Julien Demiselle, Johann Auchabie, François Beloncle, Philippe Gatault, Steven Grangé, Damien Du Cheyron, Jean Dellamonica, Sonia Boyer, Dimitri Titeca Beauport, Lise Piquilloud, Julien Letheulle, Christophe Guitton, Nicolas Chudeau, Guillaume Geri, François Fourrier, René Robert…

    Annals of Intensive Care 2017 7:39

    Published on: 5 April 2017

  7. Research

    Earlier versus later initiation of renal replacement therapy among critically ill patients with acute kidney injury: a systematic review and meta-analysis of randomized controlled trials

    Although the optimal timing of initiation of renal replacement therapy (RRT) in critically ill patients with acute kidney injury has been extensively studied in the past, it is still unclear.

    Tai-Shuan Lai, Chih-Chung Shiao, Jian-Jhong Wang, Chun-Te Huang, Pei-Chen Wu, Eric Chueh, Shih-Chieh Jeff Chueh, Kianoush Kashani and Vin-Cent Wu

    Annals of Intensive Care 2017 7:38

    Published on: 5 April 2017

  8. Research

    Diagnostic accuracy of quantitative neuromuscular ultrasound for the diagnosis of intensive care unit-acquired weakness: a cross-sectional observational study

    Neuromuscular ultrasound is a noninvasive investigation, which can be easily performed at the bedside on the ICU. A reduction in muscle thickness and increase in echo intensity over time have been described in...

    Esther Witteveen, Juultje Sommers, Luuk Wieske, Jonne Doorduin, Nens van Alfen, Marcus J. Schultz, Ivo N. van Schaik, Janneke Horn and Camiel Verhamme

    Annals of Intensive Care 2017 7:40

    Published on: 5 April 2017

  9. Research

    Long-term outcome of patients with liver cirrhosis admitted to a general intensive care unit

    The prevalence of liver cirrhosis is increasing, and many patients have acute conditions requiring consideration of intensive care. This study aims to: (a) report the outcome at 12 months of patients with cirr...

    Alex Warren, Charlotte R. Soulsby, Alex Puxty, Joseph Campbell, Martin Shaw, Tara Quasim, John Kinsella and Joanne McPeake

    Annals of Intensive Care 2017 7:37

    Published on: 4 April 2017

  10. Research

    Are third-generation cephalosporins unavoidable for empirical therapy of community-acquired pneumonia in adult patients who require ICU admission? A retrospective study

    Third-generation cephalosporins (3GCs) are recommended for empirical antibiotic therapy of community-acquired pneumonia (CAP) in patients requiring ICU admission. However, their extensive use could promote the...

    Geoffroy Hariri, Jacques Tankovic, Pierre-Yves Boëlle, Vincent Dubée, Guillaume Leblanc, Claire Pichereau, Simon Bourcier, Naike Bigé, Jean-Luc Baudel, Arnaud Galbois, Hafid Ait-Oufella and Eric Maury

    Annals of Intensive Care 2017 7:35

    Published on: 24 March 2017

  11. Research

    Implementation and evaluation of a paediatric nurse-driven sedation protocol in a paediatric intensive care unit

    Optimal sedation and analgesia is a challenge in paediatric intensive care units (PICU) because of difficulties in scoring systems and specific metabolism inducing tolerance and withdrawal. Excessive sedation ...

    Lélia Dreyfus, Etienne Javouhey, Angélique Denis, Sandrine Touzet and Fabienne Bordet

    Annals of Intensive Care 2017 7:36

    Published on: 24 March 2017

  12. Research

    Systematic overdosing of oxa- and cloxacillin in severe infections treated in ICU: risk factors and side effects

    Oxacillin and cloxacillin are the most frequently used penicillins for the treatment of severe methicillin-susceptible Staphylococcus aureus infections in intensive care units (ICUs), especially endocarditis. Int...

    Mathilde Neuville, Najoua El-Helali, Eric Magalhaes, Aguila Radjou, Roland Smonig, Jean-François Soubirou, Guillaume Voiriot, Alban Le Monnier, Stéphane Ruckly, Lila Bouadma, Romain Sonneville, Jean-François Timsit and Bruno Mourvillier

    Annals of Intensive Care 2017 7:34

    Published on: 22 March 2017

  13. Research

    Sepsis risk factors in infants with congenital diaphragmatic hernia

    Congenital diaphragmatic hernia (CDH) is a rare congenital anomaly and remains among the most challenging ICU-managed disease. Beside severe pulmonary hypertension, lung hypoplasia and major abdominal surgery,...

    Michaël Levy, Nolwenn Le Sache, Mostafa Mokhtari, Guy Fagherazzi, Gaelle Cuzon, Benjamin Bueno, Virginie Fouquet, Alexandra Benachi, Sergio Eleni Dit Trolli and Pierre Tissieres

    Annals of Intensive Care 2017 7:32

    Published on: 21 March 2017

  14. Research

    Prognosis of cirrhotic patients admitted to intensive care unit: a meta-analysis

    The best predictors of short- and medium-term mortality of cirrhotic patients receiving intensive care support are unknown.

    Delphine Weil, Eric Levesque, Marc McPhail, Rodrigo Cavallazzi, Eleni Theocharidou, Evangelos Cholongitas, Arnaud Galbois, Heng Chih Pan, Constantine J. Karvellas, Bertrand Sauneuf, René Robert, Jérome Fichet, Gaël Piton, Thierry Thevenot, Gilles Capellier and Vincent Di Martino

    Annals of Intensive Care 2017 7:33

    Published on: 21 March 2017

  15. Research

    Acute hyperventilation increases the central venous-to-arterial PCO2 difference in stable septic shock patients

    To evaluate the effects of acute hyperventilation on the central venous-to-arterial carbon dioxide tension difference (∆PCO2) in hemodynamically stable septic shock patients.

    Jihad Mallat, Usman Mohammad, Malcolm Lemyze, Mehdi Meddour, Marie Jonard, Florent Pepy, Gaelle Gasan, Stephanie Barrailler, Johanna Temime, Nicolas Vangrunderbeeck, Laurent Tronchon and Didier Thevenin

    Annals of Intensive Care 2017 7:31

    Published on: 20 March 2017

  16. Research

    Persistent lymphopenia is a risk factor for ICU-acquired infections and for death in ICU patients with sustained hypotension at admission

    Severely ill patients might develop an alteration of their immune system called post-aggressive immunosuppression. We sought to assess the risk of ICU-acquired infection and of mortality according to the abso...

    Christophe Adrie, Maxime Lugosi, Romain Sonneville, Bertrand Souweine, Stéphane Ruckly, Jean-Charles Cartier, Maité Garrouste-Orgeas, Carole Schwebel and Jean-François Timsit

    Annals of Intensive Care 2017 7:30

    Published on: 17 March 2017

  17. Research

    A hypoperfusion context may aid to interpret hyperlactatemia in sepsis-3 septic shock patients: a proof-of-concept study

    Persistent hyperlactatemia is particularly difficult to interpret in septic shock. Besides hypoperfusion, adrenergic-driven lactate production and impaired lactate clearance are important contributors. Howeve...

    Leyla Alegría, Magdalena Vera, Jorge Dreyse, Ricardo Castro, David Carpio, Carolina Henriquez, Daniela Gajardo, Sebastian Bravo, Felipe Araneda, Eduardo Kattan, Pedro Torres, Gustavo Ospina-Tascón, Jean-Louis Teboul, Jan Bakker and Glenn Hernández

    Annals of Intensive Care 2017 7:29

    Published on: 9 March 2017

  18. Research

    Multi-marker approach using procalcitonin, presepsin, galectin-3, and soluble suppression of tumorigenicity 2 for the prediction of mortality in sepsis

    Biomarker could be objective and reliable tools to predict mortality in sepsis. We explored the prognostic utilities of emerging biomarkers in septic patients and questioned whether adding biomarkers to the cl...

    Hanah Kim, Mina Hur, Hee-Won Moon, Yeo-Min Yun and Salvatore Di Somma

    Annals of Intensive Care 2017 7:27

    Published on: 7 March 2017

  19. Review

    Patient-important outcomes in randomized controlled trials in critically ill patients: a systematic review

    Intensivists’ clinical decision making pursues two main goals for patients: to decrease mortality and to improve quality of life and functional status in survivors. Patient-important outcomes are gaining wide ...

    Stéphane Gaudry, Jonathan Messika, Jean-Damien Ricard, Sylvie Guillo, Blandine Pasquet, Emeline Dubief, Tanissia Boukertouta, Didier Dreyfuss and Florence Tubach

    Annals of Intensive Care 2017 7:28

    Published on: 7 March 2017

  20. Research

    Outcomes in elderly patients admitted to the intensive care unit with solid tumors

    As the population ages and cancer therapies improve, there is an increased call for elderly cancer patients to be admitted to the intensive care unit (ICU). This study aimed to assess short-term survival and p...

    Edouard Auclin, Anaïs Charles-Nelson, Baptiste Abbar, Emmanuel Guérot, Stéphane Oudard, Caroline Hauw-Berlemont, Constance Thibault, Alexandra Monnier, Jean-Luc Diehl, Sandrine Katsahian, Jean-Yves Fagon, Julien Taieb and Nadia Aissaoui

    Annals of Intensive Care 2017 7:26

    Published on: 6 March 2017

  21. Research

    Sound level intensity severely disrupts sleep in ventilated ICU patients throughout a 24-h period: a preliminary 24-h study of sleep stages and associated sound levels

    It is well recognized that sleep is severely disturbed in patients in intensive care units (ICU) and that this can compromise their rehabilitation potential. However, it is still difficult to objectively asses...

    Maxime Elbaz, Damien Léger, Fabien Sauvet, Benoit Champigneulle, Stéphane Rio, Mélanie Strauss, Mounir Chennaoui, Christian Guilleminault and Jean Paul Mira

    Annals of Intensive Care 2017 7:25

    Published on: 3 March 2017

  22. Research

    Diagnosis of cardiac surgery-associated acute kidney injury: differential roles of creatinine, chitinase 3-like protein 1 and neutrophil gelatinase-associated lipocalin: a prospective cohort study

    A common and serious complication of cardiac surgery prompting early detection and intervention is cardiac surgery-associated acute kidney injury (CSA-AKI). Urinary chitinase 3-like protein 1 (UCHI3L1) was fou...

    Jorien De Loor, Ingrid Herck, Katrien Francois, Astrid Van Wesemael, Lieve Nuytinck, Evelyne Meyer and Eric A. J. Hoste

    Annals of Intensive Care 2017 7:24

    Published on: 1 March 2017

  23. Research

    IL-6 rs1800795 polymorphism is associated with septic shock-related death in patients who underwent major surgery: a preliminary retrospective study

    Sepsis is a life-threatening organ dysfunction caused by a dysregulated host response to infection, being the primary cause of death from infection, especially if not recognized and treated promptly. The aim o...

    Maria Angeles Jiménez-Sousa, Luz Maria Medrano, Pilar Liu, Amanda Fernández-Rodríguez, Raquel Almansa, Esther Gomez-Sanchez, Alicia Ortega, María Heredia-Rodríguez, Estefanía Gómez-Pesquera, Eduardo Tamayo and Salvador Resino

    Annals of Intensive Care 2017 7:22

    Published on: 28 February 2017

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