Relationship between plateau pressure ( Pplat ) and 111
In-transferrin lung-to-heart ratio slope (an index of lung microvascular permeability; left axis, open circles) and alveolar 99 m
Tc-albumin permeability-surface area product (an index of alveolar epithelium permeability; right axis, full circles) in mechanically ventilated rats. Both indexes dramatically increased for plateau pressures comprised between 20 and 25 cm H2O. Used with permission. From de Prost et al. .