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  1. Research

    Thrombomodulin favors leukocyte microvesicle fibrinolytic activity, reduces NETosis and prevents septic shock-induced coagulopathy in rats

    Septic shock-induced disseminated intravascular coagulation is responsible for increased occurrence of multiple organ dysfunction and mortality. Immunothrombosis-induced coagulopathy may contribute to hypercoa...

    Julie Helms, Raphaël Clere-Jehl, Elsa Bianchini, Pierrick Le Borgne, Mélanie Burban, Fatiha Zobairi, Jean-Luc Diehl, Lelia Grunebaum, Florence Toti, Ferhat Meziani and Delphine Borgel

    Annals of Intensive Care 2017 7:118

    Published on: 8 December 2017

  2. Review

    Immunohaemostasis: a new view on haemostasis during sepsis

    Host infection by a micro-organism triggers systemic inflammation, innate immunity and complement pathways, but also haemostasis activation. The role of thrombin and fibrin generation in host defence is now re...

    Xavier Delabranche, Julie Helms and Ferhat Meziani

    Annals of Intensive Care 2017 7:117

    Published on: 2 December 2017

  3. Research

    Does metformin exposure before ICU stay have any impact on patients’ outcome? A retrospective cohort study of diabetic patients

    Impact of metformin exposure before ICU stay remains controversial. Metformin is thought to induce lactic acidosis and haemodynamic instability but may reduce ICU mortality. We evaluated its influence on outco...

    Sebastien Jochmans, Jean-Emmanuel Alphonsine, Jonathan Chelly, Ly Van Phach Vong, Oumar Sy, Nathalie Rolin, Olivier Ellrodt, Mehran Monchi and Christophe Vinsonneau

    Annals of Intensive Care 2017 7:116

    Published on: 2 December 2017

  4. Review

    Blood platelets and sepsis pathophysiology: A new therapeutic prospect in critical ill patients?

    Beyond haemostasis, platelets have emerged as versatile effectors of the immune response. The contribution of platelets in inflammation, tissue integrity and defence against infections has considerably widened...

    Antoine Dewitte, Sébastien Lepreux, Julien Villeneuve, Claire Rigothier, Christian Combe, Alexandre Ouattara and Jean Ripoche

    Annals of Intensive Care 2017 7:115

    Published on: 1 December 2017

  5. Review

    Piperacillin–tazobactam as alternative to carbapenems for ICU patients

    Several studies suggest that alternatives to carbapenems, and particulary beta-lactam/beta-lactamase inhibitor combinations, can be used for therapy of extended-spectrum beta-lactamase-producing Enterobacteria...

    Benoit Pilmis, Vincent Jullien, Alexis Tabah, Jean-Ralph Zahar and Christian Brun-Buisson

    Annals of Intensive Care 2017 7:113

    Published on: 10 November 2017

  6. Research

    Venovenous extracorporeal membrane oxygenation devices-related colonisations and infections

    Nosocomial infections occurring during extracorporeal membrane oxygenation (ECMO) support have already been reported, but few studied infections directly related to ECMO devices. This study aims to evaluate t...

    Guillemette Thomas, Sami Hraiech, Nadim Cassir, Samuel Lehingue, Romain Rambaud, Sandrine Wiramus, Christophe Guervilly, Fanny Klasen, Mélanie Adda, Stéphanie Dizier, Antoine Roch, Laurent Papazian and Jean-Marie Forel

    Annals of Intensive Care 2017 7:111

    Published on: 7 November 2017

  7. Research

    Admission of tetanus patients to the ICU: a retrospective multicentre study

    An extended course of tetanus (up to 6 weeks) requiring ICU admission and protracted mechanical ventilation (MV) may have a significant impact on short- and long-term survival. The subject is noteworthy and d...

    Rafael Mahieu, Thomas Reydel, Adel Maamar, Jean-Marc Tadié, Angeline Jamet, Arnaud W. Thille, Nicolas Chudeau, Julien Huntzinger, Steven Grangé, Gaetan Beduneau, Anne Courte, Stephane Ehrmann, Jérémie Lemarié, Sébastien Gibot, Michael Darmon, Christophe Guitton…

    Annals of Intensive Care 2017 7:112

    Published on: 7 November 2017

  8. Research

    Effects of combination therapy using antithrombin and thrombomodulin for sepsis-associated disseminated intravascular coagulation

    No single anticoagulant has been proven effective for sepsis-associated disseminated intravascular coagulation (DIC). Thus, the concomitant use of antithrombin concentrate and recombinant thrombomodulin has be...

    Toshiaki Iba, Akiyoshi Hagiwara, Daizoh Saitoh, Hideaki Anan, Yutaka Ueki, Koichi Sato and Satoshi Gando

    Annals of Intensive Care 2017 7:110

    Published on: 2 November 2017

  9. Research

    Incidence of airway complications in patients using endotracheal tubes with continuous aspiration of subglottic secretions

    Continuous aspiration of subglottic secretions is effective in preventing ventilator-associated pneumonia, but it involves a risk of mucosal damage. The main objective of our study was to determine the inciden...

    Jordi Vallés, Susana Millán, Emili Díaz, Eva Castanyer, Xavier Gallardo, Ignacio Martín-Loeches, Marta Andreu, Mario Prenafeta, Paula Saludes, Jorge Lema, Montse Batlle, Néstor Bacelar and Antoni Artigas

    Annals of Intensive Care 2017 7:109

    Published on: 2 November 2017

  10. Research

    Risk stratification using SpO2/FiO2 and PEEP at initial ARDS diagnosis and after 24 h in patients with moderate or severe ARDS

    We assessed the potential of risk stratification of ARDS patients using SpO2/FiO2 and positive end-expiratory pressure (PEEP) at ARDS onset and after 24 h.

    Luigi Pisani, Jan-Paul Roozeman, Fabienne D. Simonis, Antonio Giangregorio, Sophia M. van der Hoeven, Laura R. Schouten, Janneke Horn, Ary Serpa Neto, Emir Festic, Arjen M. Dondorp, Salvatore Grasso, Lieuwe D. Bos and Marcus J. Schultz

    Annals of Intensive Care 2017 7:108

    Published on: 25 October 2017

  11. Research

    Anemia at pediatric intensive care unit discharge: prevalence and risk markers

    Anemia is prevalent at pediatric intensive care unit (PICU) admission and incident during PICU stay, but little is known about anemia at PICU discharge . Anemia after critical illness is an important issue bec...

    Pierre Demaret, Oliver Karam, Marisa Tucci, Jacques Lacroix, Hélène Behal, Alain Duhamel, Frédéric Lebrun, André Mulder and Stéphane Leteurtre

    Annals of Intensive Care 2017 7:107

    Published on: 24 October 2017

  12. Research

    Protective effect of early low-dose hydrocortisone on ventilator-associated pneumonia in the cancer patients: a propensity score analysis

    Ventilator-associated pneumonia (VAP) is a care-related event that could be promoted by immune suppression caused by critical diseases, malignancies and cancer treatments. Low dose of hydrocortisone was propos...

    David Lagier, Laura Platon, Jérome Lambert, Laurent Chow-Chine, Antoine Sannini, Magali Bisbal, Jean-Paul Brun, Karim Asehnoune, Marc Leone, Marion Faucher and Djamel Mokart

    Annals of Intensive Care 2017 7:106

    Published on: 23 October 2017

  13. Research

    Outcome of in- and out-of-hospital cardiac arrest survivors with liver cirrhosis

    Organ failure increases mortality in patients with liver cirrhosis. Data about resuscitated cardiac arrest patients with liver cirrhosis are missing. This study aims to assess aetiology, survival and functiona...

    Kevin Roedl, Christian Wallmüller, Andreas Drolz, Thomas Horvatits, Karoline Rutter, Alexander Spiel, Julia Ortbauer, Peter Stratil, Pia Hubner, Christoph Weiser, Jasmin Katrin Motaabbed, Dominik Jarczak, Harald Herkner, Fritz Sterz and Valentin Fuhrmann

    Annals of Intensive Care 2017 7:103

    Published on: 6 October 2017

  14. Research

    Ultrasound assessment of rectus femoris and anterior tibialis muscles in young trauma patients

    Quantitative and qualitative changes of skeletal muscle are typical and early findings in trauma patients, being possibly associated with functional impairment. Early assessment of muscle changes—as evaluated ...

    Maria Giuseppina Annetta, Mauro Pittiruti, Davide Silvestri, Domenico Luca Grieco, Alessio Maccaglia, Michele Fabio La Torre, Nicola Magarelli, Giovanna Mercurio, Anselmo Caricato and Massimo Antonelli

    Annals of Intensive Care 2017 7:104

    Published on: 6 October 2017

  15. Research

    Prognostic implications of blood lactate concentrations after cardiac arrest: a retrospective study

    Elevated lactate concentration has been associated with increased mortality after out-of-hospital cardiac arrest (CA). We investigated the variables associated with high blood lactate concentrations and explor...

    Antonio Maria Dell’Anna, Claudio Sandroni, Irene Lamanna, Ilaria Belloni, Katia Donadello, Jacques Creteur, Jean-Louis Vincent and Fabio Silvio Taccone

    Annals of Intensive Care 2017 7:101

    Published on: 6 October 2017

  16. Research

    Endothelial glycocalyx degradation is more severe in patients with non-pulmonary sepsis compared to pulmonary sepsis and associates with risk of ARDS and other organ dysfunction

    Disruption of the endothelial glycocalyx contributes to acute lung injury in experimental sepsis but has not been well studied in humans. To study glycocalyx degradation in sepsis-induced ARDS, we measured pla...

    Laura S. Murphy, Nancy Wickersham, J. Brennan McNeil, Ciara M. Shaver, Addison K. May, Julie A. Bastarache and Lorraine B. Ware

    Annals of Intensive Care 2017 7:102

    Published on: 6 October 2017

  17. Research

    The association between FABP7 serum levels with survival and neurological complications in acetaminophen-induced acute liver failure: a nested case–control study

    Acetaminophen (APAP)-induced acute liver failure (ALF) is associated with significant mortality due to intracranial hypertension (ICH), a result of cerebral edema (CE) and astrocyte swelling. Brain-type fatty ...

    Constantine J. Karvellas, Jaime L. Speiser, Mélanie Tremblay, William M. Lee and Christopher F. Rose

    Annals of Intensive Care 2017 7:99

    Published on: 5 October 2017

  18. Research

    Interstitial pneumonia with autoimmune features: an additional risk factor for ARDS?

    Interstitial pneumonia with autoimmune features (IPAF) identifies a recently recognized autoimmune syndrome characterized by interstitial lung disease and autoantibodies positivity, but absence of a specific c...

    Giacomo Grasselli, Beatrice Vergnano, Maria Rosa Pozzi, Vittoria Sala, Gabriele D’Andrea, Vittorio Scaravilli, Marco Mantero, Alberto Pesci and Antonio Pesenti

    Annals of Intensive Care 2017 7:98

    Published on: 18 September 2017

  19. Research

    Derivation and validation of a prognostic model for postoperative risk stratification of critically ill patients with faecal peritonitis

    Prognostic scores and models of illness severity are useful both clinically and for research. The aim of this study was to develop two prognostic models for the prediction of long-term (6 months) and 28-day m...

    Ascanio Tridente, Julian Bion, Gary H. Mills, Anthony C. Gordon, Geraldine. M. Clarke, Andrew Walden, Paula Hutton, Paul A. H. Holloway, Jean-Daniel Chiche, Frank Stuber, Christopher Garrard and Charles Hinds

    Annals of Intensive Care 2017 7:96

    Published on: 12 September 2017

  20. Research

    High level of venous thromboembolism in critically ill trauma patients despite early and well-driven thromboprophylaxis protocol

    Venous thromboembolism (VTE) is one of the most common preventable causes of in-hospital death in trauma patients surviving their injuries. We assessed the prevalence, incidence and risk factors for deep venou...

    S. R. Hamada, C. Espina, T. Guedj, R. Buaron, A. Harrois, S. Figueiredo and J. Duranteau

    Annals of Intensive Care 2017 7:97

    Published on: 12 September 2017

  21. Research

    Short-term effects of passive mobilization on the sublingual microcirculation and on the systemic circulation in patients with septic shock

    Active mobilization is not possible in patients under deep sedation and unable to follow commands. In this scenario, passive therapy is an interesting alternative. However, in patients with septic shock, passi...

    Tuanny Teixeira Pinheiro, Flávio Geraldo Rezende de Freitas, Karla Tuanny Fiorese Coimbra, Vanessa Marques Ferreira Mendez, Heloísa Baccaro Rossetti, Paulo Vinicius Talma, Antônio Tonete Bafi and Flávia Ribeiro Machado

    Annals of Intensive Care 2017 7:95

    Published on: 8 September 2017

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