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  1. The ongoing coronavirus disease 2019 (COVID-2019) pandemic has swept all over the world, posing a great pressure on critical care resources due to large number of patients needing critical care. Statements fro...

    Authors: You Shang, Chun Pan, Xianghong Yang, Ming Zhong, Xiuling Shang, Zhixiong Wu, Zhui Yu, Wei Zhang, Qiang Zhong, Xia Zheng, Ling Sang, Li Jiang, Jiancheng Zhang, Wei Xiong, Jiao Liu and Dechang Chen

    Citation: Annals of Intensive Care 2020 10:73

    Content type: Review

    Published on:

  2. An amendment to this paper has been published and can be accessed via the original article.

    Authors: Florian Blanchard, Judith Charbit, Guillaume Van der Meersch, Benjamin Popoff, Adrien Picod, Regis Cohen, Frank Chemouni, Stephane Gaudry, Helene Bihan and Yves Cohen

    Citation: Annals of Intensive Care 2020 10:72

    Content type: Correction

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    The original article was published in Annals of Intensive Care 2020 10:58

  3. A recent increase in children admitted with hypotensive shock and fever in the context of the COVID-19 outbreak requires an urgent characterization and assessment of the involvement of SARS-CoV-2 infection. Th...

    Authors: Marion Grimaud, Julie Starck, Michael Levy, Clémence Marais, Judith Chareyre, Diala Khraiche, Marianne Leruez-Ville, Pierre Quartier, Pierre Louis Léger, Guillaume Geslain, Nada Semaan, Florence Moulin, Matthieu Bendavid, Sandrine Jean, Géraldine Poncelet, Sylvain Renolleau…

    Citation: Annals of Intensive Care 2020 10:69

    Content type: Research

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  4. Survival benefit from low tidal volume (VT) ventilation (LTVV) has been demonstrated for patients with acute respiratory distress syndrome (ARDS), and patients not having ARDS could also benefit from this strateg...

    Authors: Thais Dias Midega, Fernando A. Bozza, Flávia Ribeiro Machado, Helio Penna Guimarães, Jorge I. Salluh, Antonio Paulo Nassar Jr., Karina Normílio-Silva, Marcus J. Schultz, Alexandre Biasi Cavalcanti and Ary Serpa Neto

    Citation: Annals of Intensive Care 2020 10:68

    Content type: Research

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  5. Inappropriate ventilator assist plays an important role in the development of diaphragm dysfunction. Ventilator under-assist may lead to muscle injury, while over-assist may result in muscle atrophy. This prov...

    Authors: L. H. Roesthuis, J. G. van der Hoeven, H. W. H. van Hees, W.-J. M. Schellekens, J. Doorduin and L. M. A. Heunks

    Citation: Annals of Intensive Care 2020 10:67

    Content type: Research

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  6. Prone position (PP) is highly recommended in moderate-to-severe ARDS. However, the optimal duration of PP sessions remains unclear. We searched to evaluate the time required to obtain the maximum physiological...

    Authors: Sebastien Jochmans, Sandie Mazerand, Jonathan Chelly, Franck Pourcine, Oumar Sy, Nathalie Thieulot-Rolin, Olivier Ellrodt, Emmanuelle Mercier Des Rochettes, Gaël Michaud, Jean Serbource-Goguel, Christophe Vinsonneau, Ly Van Phach Vong and Mehran Monchi

    Citation: Annals of Intensive Care 2020 10:66

    Content type: Research

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  7. We performed a systematic review and meta-analysis of studies assessing the end-expiratory occlusion test (EEXPO test)-induced changes in cardiac output (CO) measured by any haemodynamic monitoring device, as ...

    Authors: Francesco Gavelli, Rui Shi, Jean-Louis Teboul, Danila Azzolina and Xavier Monnet

    Citation: Annals of Intensive Care 2020 10:65

    Content type: Research

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  8. Intravenous fluid administration should be considered as any other pharmacological prescription. There are three main indications: resuscitation, replacement, and maintenance. Moreover, the impact of fluid adm...

    Authors: Manu L. N. G. Malbrain, Thomas Langer, Djillali Annane, Luciano Gattinoni, Paul Elbers, Robert G. Hahn, Inneke De laet, Andrea Minini, Adrian Wong, Can Ince, David Muckart, Monty Mythen, Pietro Caironi and Niels Van Regenmortel

    Citation: Annals of Intensive Care 2020 10:64

    Content type: Review

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  9. No recommendation exists about the timing and setting for tracheal intubation and mechanical ventilation in septic shock.

    Authors: C. Darreau, F. Martino, M. Saint-Martin, S. Jacquier, J. F. Hamel, M. A. Nay, N. Terzi, G. Ledoux, F. Roche-Campo, L. Camous, F. Pene, T. Balzer, F. Bagate, J. Lorber, P. Bouju, C. Marois…

    Citation: Annals of Intensive Care 2020 10:62

    Content type: Research

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  10. COVID-19 is an emerging disease of public health concern. While there is no specific recommended treatment for COVID-19, nitric oxide has the potential to be of therapeutic value for managing acute respiratory...

    Authors: Jun Kobayashi and Isamu Murata

    Citation: Annals of Intensive Care 2020 10:61

    Content type: Letter to the Editor

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  11. Bacterial infections are frequent triggers for diabetic ketoacidosis. In this context, delayed antibiotic treatment is associated with increased morbidity and mortality. Unnecessary administration of antimicro...

    Authors: Florian Blanchard, Judith Charbit, Guillaume Van der Meersch, Benjamin Popoff, Adrien Picod, Regis Cohen, Frank Chemouni, Stephane Gaudry, Helene Bihan and Yves Cohen

    Citation: Annals of Intensive Care 2020 10:58

    Content type: Research

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  12. Although recently published randomised controlled trials did not confirm significant positive effect of ART-123 or polymyxin B‑immobilised haemoperfusion (PMX-HP) on survival outcome, previous studies using a ...

    Authors: Katsunori Mochizuki, Kotaro Mori, Hiroshi Kamijo, Michitaro Ichikawa, Kenichi Nitta and Hiroshi Imamura

    Citation: Annals of Intensive Care 2020 10:57

    Content type: Research

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  13. The number of intensive care patients aged ≥ 80 years (Very old Intensive Care Patients; VIPs) is growing. VIPs have high mortality and morbidity and the benefits of ICU admission are frequently questioned. Se...

    Authors: Mercedes Ibarz, Ariane Boumendil, Lenneke E. M. Haas, Marian Irazabal, Hans Flaatten, Dylan W. de Lange, Alessandro Morandi, Finn H. Andersen, Guido Bertolini, Maurizio Cecconi, Steffen Christensen, Loredana Faraldi, Jesper Fjølner, Christian Jung, Brian Marsh, Rui Moreno…

    Citation: Annals of Intensive Care 2020 10:56

    Content type: Research

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  14. A large proportion of patients with a SARS-Cov-2-associated respiratory failure develop an acute respiratory distress syndrome (ARDS). It has been recently suggested that SARS-Cov-2-associated ARDS may differ ...

    Authors: François M. Beloncle, Bertrand Pavlovsky, Christophe Desprez, Nicolas Fage, Pierre-Yves Olivier, Pierre Asfar, Jean-Christophe Richard and Alain Mercat

    Citation: Annals of Intensive Care 2020 10:55

    Content type: Research

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  15. Weaning from mechanical ventilation (MV) is a cardiovascular stress test. Monitoring the regional oxygenation status has shown promising results in predicting the tolerance to spontaneously breathe in the proc...

    Authors: Jaume Mesquida, Guillem Gruartmoner, Cristina Espinal, Jordi Masip, Caroline Sabatier, Ana Villagrá, Hernando Gómez, Michael Pinsky, Francisco Baigorri and Antonio Artigas

    Citation: Annals of Intensive Care 2020 10:54

    Content type: Research

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  16. Most prognostic studies in acute stroke patients requiring invasive mechanical ventilation are outdated and have limitations such as single-center retrospective designs. We aimed to study the association of IC...

    Authors: Etienne de Montmollin, Nicolas Terzi, Claire Dupuis, Maité Garrouste-Orgeas, Daniel da Silva, Michaël Darmon, Virginie Laurent, Guillaume Thiéry, Johana Oziel, Guillaume Marcotte, Marc Gainnier, Shidasp Siami, Benjamin Sztrymf, Christophe Adrie, Jean Reignier, Stephane Ruckly…

    Citation: Annals of Intensive Care 2020 10:53

    Content type: Research

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  17. Acute respiratory distress syndrome (ARDS) is a life-threatening condition that often requires prolonged mechanical ventilation. Tracheostomy is a common procedure with some risks, on the other hand with poten...

    Authors: Sebastian Blecha, Magdalena Brandl, Florian Zeman, Frank Dodoo-Schittko, Susanne Brandstetter, Christian Karagiannidis, Thomas Bein and Christian Apfelbacher

    Citation: Annals of Intensive Care 2020 10:52

    Content type: Research

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  18. Neutrophil gelatinase-associated lipocalin (NGAL) is released from kidney tubular cells under stress as well as from neutrophils during inflammation. It has been suggested as a biomarker for acute kidney injur...

    Authors: Sanna Törnblom, Sara Nisula, Liisa Petäjä, Suvi T. Vaara, Mikko Haapio, Eero Pesonen and Ville Pettilä

    Citation: Annals of Intensive Care 2020 10:51

    Content type: Research

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  19. In this survey endorsed by the European Society of Intensive Care Medicine (ESICM), we aimed to describe the practice patterns of intensivists worldwide, regarding their diagnosis and management of respiratory...

    Authors: Quentin Philippot, Vincent Labbé, Jérémie Pichon, Michel Djibré, Muriel Fartoukh and Guillaume Voiriot

    Citation: Annals of Intensive Care 2020 10:50

    Content type: Letter to the Editor

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  20. The echocardiography working group of the European Society of Intensive Care Medicine recognized the need to provide structured guidance for future CCE research methodology and reporting based on a systematic ...

    Authors: S. Huang, F. Sanfilippo, A. Herpain, M. Balik, M. Chew, F. Clau-Terré, C. Corredor, D. De Backer, N. Fletcher, G. Geri, A. Mekontso-Dessap, A. McLean, A. Morelli, S. Orde, T. Petrinic, M. Slama…

    Citation: Annals of Intensive Care 2020 10:49

    Content type: Review

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  21. Infection and sepsis are a main cause of acute-on-chronic liver failure (ACLF). Adequate dosing of antimicrobial therapy is of central importance to improve outcome. Liver failure may alter antibiotic drug con...

    Authors: Jörn Grensemann, David Busse, Christina König, Kevin Roedl, Walter Jäger, Dominik Jarczak, Stefanie Iwersen-Bergmann, Carolin Manthey, Stefan Kluge, Charlotte Kloft and Valentin Fuhrmann

    Citation: Annals of Intensive Care 2020 10:48

    Content type: Research

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  22. Despite improvements in intermittent hemodialysis management, intradialytic hemodynamic instability (IHI) remains a common issue that could account for increased mortality and delayed renal recovery. However, ...

    Authors: Naïke Bigé, Jean-Rémi Lavillegrand, Julien Dang, Philippe Attias, Stéphanie Deryckere, Jérémie Joffre, Vincent Dubée, Gabriel Preda, Guillaume Dumas, Geoffroy Hariri, Claire Pichereau, Jean-Luc Baudel, Bertrand Guidet, Eric Maury, Pierre-Yves Boelle and Hafid Ait-Oufella

    Citation: Annals of Intensive Care 2020 10:47

    Content type: Research

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  23. Biomarkers can play a critical role by facilitating diagnosis and stratification of disease, as well as assessment or prediction of disease severity. Urinary tissue inhibitor of metalloproteinase-2 and insulin...

    Authors: Ilaria Godi, Silvia De Rosa, Francesca Martino, Simona Bazzano, Marina Martin, Elisa Boni, Maria Rosa Carta, Claudia Tamayo Diaz, Gaia Mari, Anna Lorenzin, Massimo de Cal, Valentina Corradi, Carlotta Caprara, Davide Giavarina and Claudio Ronco

    Citation: Annals of Intensive Care 2020 10:46

    Content type: Research

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  24. Since the 2019 novel coronavirus disease (COVID-19) outbreak originated from Wuhan, Hubei Province, China, at the end of 2019, it has become a clinical threat to the general population worldwide. Among people ...

    Authors: Lei Li, Ranran Li, Zhixiong Wu, Xianghong Yang, Mingyan Zhao, Jiao Liu and Dechang Chen

    Citation: Annals of Intensive Care 2020 10:45

    Content type: Review

    Published on:

  25. To describe acute kidney injury (AKI) natural history and to identify predictors of major adverse kidney events (MAKE) within 1 year in patients supported by veno-arterial extracorporeal membrane oxygenation (...

    Authors: Camille Vinclair, Etienne De Montmollin, Romain Sonneville, Jean Reuter, Jordane Lebut, Radj Cally, Bruno Mourvillier, Mathilde Neuville, Stéphane Ruckly, Jean-François Timsit and Lila Bouadma

    Citation: Annals of Intensive Care 2020 10:44

    Content type: Research

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  26. Acute kidney injury (AKI) is a common problem in critically ill patients and associated with high rates of morbidity and mortality. Recently, Major Adverse Kidney Events (MAKE) were introduced as important kid...

    Authors: Theerapon Sukmark, Nuttha Lumlertgul, Kearkiat Praditpornsilpa, Kriang Tungsanga, Somchai Eiam-Ong and Nattachai Srisawat

    Citation: Annals of Intensive Care 2020 10:42

    Content type: Research

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  27. Loss of vascular tone is a key pathophysiological feature of septic shock. Combination of gradual diastolic hypotension and tachycardia could reflect more serious vasodilatory conditions. We sought to evaluate...

    Authors: Gustavo A. Ospina-Tascón, Jean-Louis Teboul, Glenn Hernandez, Ingrid Alvarez, Alvaro I. Sánchez-Ortiz, Luis E. Calderón-Tapia, Ramiro Manzano-Nunez, Edgardo Quiñones, Humberto J. Madriñan-Navia, Juan E. Ruiz, José L. Aldana and Jan Bakker

    Citation: Annals of Intensive Care 2020 10:41

    Content type: Research

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  28. Resuscitation of septic patients regarding goals, monitoring aspects and therapy is highly variable. Our aim was to characterize cardiovascular and fluid management of sepsis in Argentina, a low and middle-inc...

    Authors: Arnaldo Dubin, Cecilia Loudet, Vanina S. Kanoore Edul, Javier Osatnik, Fernando Ríos, Daniela Vásquez, Mario Pozo, Bernardo Lattanzio, Fernando Pálizas, Francisco Klein, Damián Piezny, Paolo N. Rubatto Birri, Graciela Tuhay, Analía García, Analía Santamaría, Graciela Zakalik…

    Citation: Annals of Intensive Care 2020 10:40

    Content type: Research

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  29. Pendelluft, the movement of gas within different lung regions, is present in animal models of assisted mechanical ventilation and associated with lung overstretching. Due to rebreathing of CO2 as compared to fres...

    Authors: Andrea Coppadoro, Alice Grassi, Cecilia Giovannoni, Francesca Rabboni, Nilde Eronia, Alfio Bronco, Giuseppe Foti, Roberto Fumagalli and Giacomo Bellani

    Citation: Annals of Intensive Care 2020 10:39

    Content type: Research

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  30. The aim of the study was to detect differences in the conjunctival microcirculation between septic patients and healthy subjects and to evaluate the course of conjunctival and retinal microvasculature in survi...

    Authors: Jurate Simkiene, Zivile Pranskuniene, Astra Vitkauskiene, Vidas Pilvinis, E. Christiaan Boerma and Andrius Pranskunas

    Citation: Annals of Intensive Care 2020 10:38

    Content type: Research

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  31. The outbreak of a novel coronavirus (2019-nCoV)-infected pneumonia (NCIP) is currently ongoing in China. Most of the critically ill patients received high-flow nasal cannula (HFNC) oxygen therapy. However, the...

    Authors: Ke Wang, Wei Zhao, Ji Li, Weiwei Shu and Jun Duan

    Citation: Annals of Intensive Care 2020 10:37

    Content type: Research

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  32. Lactate is a robust prognostic marker for the outcome of critically ill patients. Several small studies reported that metformin users have higher lactate levels at ICU admission without a concomitant increase ...

    Authors: Rene A. Posma, Trine Frøslev, Bente Jespersen, Iwan C. C. van der Horst, Daan J. Touw, Reimar W. Thomsen, Maarten W. Nijsten and Christian F. Christiansen

    Citation: Annals of Intensive Care 2020 10:36

    Content type: Research

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  33. Ventilation/perfusion inequalities impair gas exchange in acute respiratory distress syndrome (ARDS). Although increased dead-space ventilation (VD/VT) has been described in ARDS, its mechanism is not clearly und...

    Authors: Gustavo A. Ospina-Tascón, Diego F. Bautista, Humberto J. Madriñán, Juan D. Valencia, William F. Bermúdez, Edgardo Quiñones, Luis Eduardo Calderón-Tapia, Glenn Hernandez, Alejandro Bruhn and Daniel De Backer

    Citation: Annals of Intensive Care 2020 10:35

    Content type: Research

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  34. Evidence supporting corticosteroids adjunctive treatment (CAT) for Pneumocystis jirovecii pneumonia (PCP) in non-HIV patients is highly controversial. We aimed to systematically review the literature and perform ...

    Authors: Lin Ding, Huixue Huang, Heyan Wang and Hangyong He

    Citation: Annals of Intensive Care 2020 10:34

    Content type: Research

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  35. Severe acute kidney injury (AKI), especially when caused or accompanied by sepsis, is associated with prolonged hospitalization, progression to chronic kidney disease (CKD), financial burden, and high mortalit...

    Authors: Ayman Karkar and Claudio Ronco

    Citation: Annals of Intensive Care 2020 10:32

    Content type: Review

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  36. High-frequency oscillatory ventilation (HFOV) may theoretically provide lung protective ventilation. The negative clinical results may be due to inadequate mean airway pressure (mPaw) settings in HFOV. Our obj...

    Authors: Songqiao Liu, Zhanqi Zhao, Li Tan, Lihui Wang, Knut Möller, Inéz Frerichs, Tao Yu, Yingzi Huang, Chun Pan, Yi Yang and Haibo Qiu

    Citation: Annals of Intensive Care 2020 10:31

    Content type: Research

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  37. The optimal timing of renal replacement therapy (RRT) initiation is debatable. Many articles in this field enrolled trials not based on acute kidney injury. The safety of the watchful waiting strategy has not ...

    Authors: Jia-Jin Chen, Cheng-Chia Lee, George Kuo, Pei-Chun Fan, Chan-Yu Lin, Su-Wei Chang, Ya-Chung Tian, Yung-Chang Chen and Chih-Hsiang Chang

    Citation: Annals of Intensive Care 2020 10:30

    Content type: Research

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  38. After publication of the original article [1], we were notified that family names have been exchanged with the first names for all authors. Below the name are tagged correctly:

    Authors: Jordane Lebut, Bruno Mourvillier, Nicolas Argy, Claire Dupuis, Camille Vinclair, Aguila Radjou, Etienne de Montmollin, Fabrice Sinnah, Juliette Patrier, Clément Le Bihan, Eric Magalahes, Roland Smonig, Eric Kendjo, Marc Thellier, Stéphane Ruckly, Lila Bouadma…

    Citation: Annals of Intensive Care 2020 10:29

    Content type: Correction

    Published on:

    The original article was published in Annals of Intensive Care 2020 10:21

  39. It has been suggested that, by recruiting lung regions and enlarging the distribution volume of the cold indicator, increasing the positive end-expiratory pressure (PEEP) may lead to an artefactual overestimat...

    Authors: Francesco Gavelli, Jean-Louis Teboul, Danila Azzolina, Alexandra Beurton, Temistocle Taccheri, Imane Adda, Christopher Lai, Gian Carlo Avanzi and Xavier Monnet

    Citation: Annals of Intensive Care 2020 10:28

    Content type: Research

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  40. Rhabdomyolysis is a life-threatening disease that can lead to severe hyperkalemia, acute kidney injury (AKI) and hypovolemic shock. The predictive factors of AKI and acute to chronic kidney disease (CKD) trans...

    Authors: Nelly Candela, Stein Silva, Bernard Georges, Claire Cartery, Thomas Robert, Julie Moussi-Frances, Eric Rondeau, Jean-Michel Rebibou, Laurence Lavayssiere, Julie Belliere, Thierry Krummel, Céline Lebas, Olivier Cointault, Marion Sallee and Stanislas Faguer

    Citation: Annals of Intensive Care 2020 10:27

    Content type: Research

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  41. Corticosteroid treatment has been widely used in the treatment of septic shock, influenza, and ARDS, although some previous studies discourage its use in severe influenza patients. This multicenter retrospecti...

    Authors: Ming-Ju Tsai, Kuang-Yao Yang, Ming-Cheng Chan, Kuo-Chin Kao, Hao-Chien Wang, Wann-Cherng Perng, Chieh-Liang Wu, Shinn-Jye Liang, Wen-Feng Fang, Jong-Rung Tsai, Wei-An Chang, Ying-Chun Chien, Wei-Chih Chen, Han-Chung Hu, Chiung-Yu Lin, Wen-Cheng Chao…

    Citation: Annals of Intensive Care 2020 10:26

    Content type: Research

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  42. Right ventricular (RV) function evaluation by echocardiography is key in the management of ICU patients with acute respiratory distress syndrome (ARDS), however, it remains challenging. Quantification of RV de...

    Authors: Jérémie Lemarié, Charles-Henri Maigrat, Antoine Kimmoun, Nathalie Dumont, Pierre-Edouard Bollaert, Christine Selton-Suty, Sébastien Gibot and Olivier Huttin

    Citation: Annals of Intensive Care 2020 10:24

    Content type: Research

    Published on:

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