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  1. Red blood cell (RBC) transfusions are associated with risks including immunological reactions and volume overload. Current guidelines suggest a restrictive transfusion strategy in most patients with sepsis but...

    Authors: Caroline Ulfsdotter Nilsson, Peter Bentzer, Linnéa E. Andersson, Sofia A. Björkman, Fredrik P. Hanssson and Thomas Kander

    Citation: Annals of Intensive Care 2020 10:111

    Content type: Research

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  2. The COVID-19 pandemic has resulted in an unprecedented healthcare crisis with a high prevalence of psychological distress in healthcare providers. We sought to document the prevalence of burnout syndrome among...

    Authors: Elie Azoulay, Jan De Waele, Ricard Ferrer, Thomas Staudinger, Marta Borkowska, Pedro Povoa, Katerina Iliopoulou, Antonio Artigas, Stefan J. Schaller, Manu Shankar Hari, Mariangela Pellegrini, Michael Darmon, Jozef Kesecioglu and Maurizio Cecconi

    Citation: Annals of Intensive Care 2020 10:110

    Content type: Research

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  3. Hypoxemia is the main feature of COVID-19-related acute respiratory distress syndrome (C-ARDS), but its underlying mechanisms are debated, especially in patients with low respiratory system elastance (Ers). We...

    Authors: Paul Masi, François Bagate, Thomas d’Humières, Lara Al-Assaad, Laure Abou Chakra, Genevieve Derumeaux and Armand Mekontso Dessap

    Citation: Annals of Intensive Care 2020 10:108

    Content type: Letter to the Editor

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  4. Protective mechanical ventilation (MV) aims at limiting global lung deformation and has been associated with better clinical outcomes in acute respiratory distress syndrome (ARDS) patients. In ARDS lungs witho...

    Authors: Daniel E. Hurtado, Benjamín Erranz, Felipe Lillo, Mauricio Sarabia-Vallejos, Pablo Iturrieta, Felipe Morales, Katherine Blaha, Tania Medina, Franco Diaz and Pablo Cruces

    Citation: Annals of Intensive Care 2020 10:107

    Content type: Research

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  5. In critically ill patients, tigecycline (TGC) remains an important therapeutic option due to its efficacy against multiresistant Gram-positive and Gram-negative bacteria. TGC is metabolized and eliminated pred...

    Authors: Rawan Alraish, Sebastian G. Wicha, Otto R. Frey, Anka C. Roehr, Johann Pratschke, Martin Stockmann, Tilo Wuensch and Magnus Kaffarnik

    Citation: Annals of Intensive Care 2020 10:106

    Content type: Research

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  6. Delirium is common in intensive care patients and is associated with short- and long-term adverse outcomes. We investigated the long-term risk of cognitive impairment and post-traumatic stress disorder (PTSD) ...

    Authors: Daniella Bulic, Michael Bennett, Ekavi N. Georgousopoulou, Yahya Shehabi, Tai Pham, Jeffrey C. L. Looi and Frank M. P. van Haren

    Citation: Annals of Intensive Care 2020 10:104

    Content type: Research

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  7. Differentiating Ventilator-Associated Tracheobronchitis (VAT) from Ventilator-Associated Pneumonia (VAP) may be challenging for clinicians, yet their management currently differs. In this study, we evaluated t...

    Authors: Alexandre Gaudet, Ignacio Martin-Loeches, Pedro Povoa, Alejandro Rodriguez, Jorge Salluh, Alain Duhamel and Saad Nseir

    Citation: Annals of Intensive Care 2020 10:101

    Content type: Research

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  8. Since December 2019, an outbreak of Coronavirus disease 2019 (COVID-19) caused by the severe acute respiratory syndrome coronavirus 2 (SARS-Cov-2) initially emerged in Wuhan, China, and has spread worldwide no...

    Authors: Jiao Liu, Sheng Zhang, Zhixiong Wu, You Shang, Xuan Dong, Guang Li, Lidi Zhang, Yizhu Chen, Xiaofei Ye, Hangxiang Du, Yongan Liu, Tao Wang, SiSi Huang, Limin Chen, Zhenliang Wen, Jieming Qu…

    Citation: Annals of Intensive Care 2020 10:99

    Content type: Research

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  9. Anemia is very common in critical care patients, on admission (affecting about two-thirds of patients), but also during and after their stay, due to repeated blood loss, the effects of inflammation on erythrop...

    Authors: Sigismond Lasocki, Frédéric Pène, Hafid Ait-Oufella, Cécile Aubron, Sylvain Ausset, Pierre Buffet, Olivier Huet, Yoann Launey, Matthieu Legrand, Thomas Lescot, Armand Mekontso Dessap, Michael Piagnerelli, Hervé Quintard, Lionel Velly, Antoine Kimmoun and Gérald Chanques

    Citation: Annals of Intensive Care 2020 10:97

    Content type: Review

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  10. Prevalence of multiple organ failure (MOF) in critically ill patients is increasing and associated mortality remains high. Extracorporeal organ support is a cornerstone in the management of MOF. We report data...

    Authors: Valentin Fuhrmann, Theresa Weber, Kevin Roedl, Jasmin Motaabbed, Adel Tariparast, Dominik Jarczak, Aritz Perez Ruiz de Garibay, Johannes Kluwe, Olaf Boenisch, Harald Herkner, John A. Kellum and Stefan Kluge

    Citation: Annals of Intensive Care 2020 10:96

    Content type: Research

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  11. In critically ill patients, the use of high tigecycline dosages (HD TGC) (200 mg/day) has been recently increasing but few pharmacokinetic/pharmacodynamic (PK/PD) data are available. We designed a prospective ...

    Authors: Gennaro De Pascale, Lucia Lisi, Gabriella Maria Pia Ciotti, Maria Sole Vallecoccia, Salvatore Lucio Cutuli, Laura Cascarano, Camilla Gelormini, Giuseppe Bello, Luca Montini, Simone Carelli, Valentina Di Gravio, Mario Tumbarello, Maurizio Sanguinetti, Pierluigi Navarra and Massimo Antonelli

    Citation: Annals of Intensive Care 2020 10:94

    Content type: Research

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  12. There is no gold standard to diagnose septic shock-induced disseminated intravascular coagulation (DIC). The objective of our multicenter prospective study was to assess the performances of the different major...

    Authors: Julie Helms, François Severac, Hamid Merdji, Raphaël Clere-Jehl, Bruno François, Emmanuelle Mercier, Jean-Pierre Quenot and Ferhat Meziani

    Citation: Annals of Intensive Care 2020 10:92

    Content type: Research

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  13. Grown-up congenital heart (GUCH) patients represent a growing population with a high morbidity risk when undergoing reparative surgery. A main preoperative feature is right ventricular failure, which represent...

    Authors: Philippe Mauriat, Mirela Bojan, Sylvie Soulie, Hélène Foulgoc, Nadir Tafer and Alexandre Ouattara

    Citation: Annals of Intensive Care 2020 10:91

    Content type: Research

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  14. The present study aimed at comparing the success rate and safety of proximal versus distal approach for ultrasound (US)-guided axillary vein catheterization (AVC) in cardiac surgery patients susceptible to ble...

    Authors: Ying Su, Jun-yi Hou, Guo-guang Ma, Guang-wei Hao, Jing-chao Luo, Shen-ji Yu, Kai Liu, Ji-li Zheng, Yan Xue, Zhe Luo and Guo-wei Tu

    Citation: Annals of Intensive Care 2020 10:90

    Content type: Research

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  15. The impact on infectious risk of ultrasound guidance at insertion remains controversial in short-term arterial catheters (ACs). The present study investigated the association between ultrasound guidance (US) d...

    Authors: Niccolò Buetti, Stéphane Ruckly, Jean-Christophe Lucet, Lila Bouadma, Carole Schwebel, Olivier Mimoz and Jean-François Timsit

    Citation: Annals of Intensive Care 2020 10:89

    Content type: Research

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  16. Recirculation during veno-venous extracorporeal membrane oxygenation (VV-ECMO) is a known drawback that limits sufficient oxygenation. This study aimed to compare the short-term oxygenation and long-term morta...

    Authors: Sung Yoon Lim, Soyeon Ahn, Sang-Bum Hong, Chi Ryang Chung, Kyeongman Jeon, Sang-Min Lee, Woo Hyun Cho, Sunghoon Park and Young-Jae Cho

    Citation: Annals of Intensive Care 2020 10:86

    Content type: Research

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  17. The endothelial glycocalyx comprises a complex layer of membrane-bound proteoglycans, secreted glycosaminoglycans, glycoproteins, glycolipids and bound plasma proteins such as albumin and antithrombin associat...

    Authors: Cesar Aldecoa, Juan V. Llau, Xavier Nuvials and Antonio Artigas

    Citation: Annals of Intensive Care 2020 10:85

    Content type: Review

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  18. The devastating pandemic that has stricken the worldwide population induced an unprecedented influx of patients in ICUs, raising ethical concerns not only surrounding triage and withdrawal of life support deci...

    Authors: René Robert, Nancy Kentish-Barnes, Alexandre Boyer, Alexandra Laurent, Elie Azoulay and Jean Reignier

    Citation: Annals of Intensive Care 2020 10:84

    Content type: Review

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  19. Limited data are available on the impact of a specialized extracorporeal membrane oxygenation (ECMO) team on clinical outcomes in patients with acute myocardial infarction (AMI) complicated by cardiogenic shoc...

    Authors: David Hong, Ki Hong Choi, Yang Hyun Cho, Su Hyun Cho, So Jin Park, Darae Kim, Taek Kyu Park, Joo Myung Lee, Young Bin Song, Jin-Oh Choi, Joo-Yong Hahn, Seung-Hyuk Choi, Jin-Ho Choi, Kiick Sung, Hyeon-Cheol Gwon, Eun-Seok Jeon…

    Citation: Annals of Intensive Care 2020 10:83

    Content type: Research

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  20. Recent guidelines advise against prophylactic antibiotics in patients with necrotizing pancreatitis, advocating instead a step-up drainage and necrosectomy strategy with antibiotics as dictated by microbiologi...

    Authors: Charlotte Garret, Emmanuel Canet, Stéphane Corvec, David Boutoille, Matthieu Péron, Isabelle Archambeaud, Aurélie Le Thuaut, Jean-Baptiste Lascarrou, Frédéric Douane, Marc Lerhun, Nicolas Regenet, Emmanuel Coron and Jean Reignier

    Citation: Annals of Intensive Care 2020 10:82

    Content type: Research

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  21. High-dose methotrexate (HD-MTX) is commonly used in the treatment of solid tumors and hematological malignancies. Severe toxicities are frequent, leading to organ dysfunction and death. Risk–benefit ratio of u...

    Authors: Sandrine Valade, Eric Mariotte, Elie Azoulay and Michael Darmon

    Citation: Annals of Intensive Care 2020 10:81

    Content type: Research

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  22. Endotoxins can induce an excessive inflammatory response and result in microcirculatory dysfunction. Polymyxin-B hemoperfusion (PMX-HP) has been recognized to effectively remove endotoxins in patients with sep...

    Authors: Shih-Hong Chen, Wing-Sum Chan, Chih-Min Liu, Ching-Tang Chiu, Anne Chao, Vin-Cent Wu, Wang-Huei Sheng, Chien-Heng Lai, Ming-Jiuh Wang and Yu-Chang Yeh

    Citation: Annals of Intensive Care 2020 10:80

    Content type: Research

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  23. Although many techniques have been introduced to facilitate nasogastric tube (NGT) insertion using anatomic landmarks and a group of devices, there is a lack of general consensus regarding a standard method. T...

    Authors: Sarvin Sanaie, Negin Mirzalou, Kamran Shadvar, Samad E. J. Golzari, Hassan Soleimanpour, Ali Shamekh, Deepti Bettampadi, Saeid Safiri and Ata Mahmoodpoor

    Citation: Annals of Intensive Care 2020 10:79

    Content type: Research

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  24. Aminoglycosides have a concentration-dependent therapeutic effect when peak serum concentration (Cmax) reaches eight to tenfold the minimal inhibitory concentration (MIC). With an amikacin MIC of 8 mg/L, the Cmax

    Authors: Elsa Logre, Maya Enser, Sébastien Tanaka, Marie Dubert, Aurore Claudinon, Nathalie Grall, Hervé Mentec, Philippe Montravers and Olivier Pajot

    Citation: Annals of Intensive Care 2020 10:75

    Content type: Research

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  25. Mucormycosis is an invasive fungal infection, with an increasing incidence especially in patients with hematological malignancies. Its prognosis is poor because of its high invasive power and its intrinsic low...

    Authors: Johanna Claustre, Romaric Larcher, Thomas Jouve, Anne-Sophie Truche, Saad Nseir, Julien Cadiet, Yoann Zerbib, Alexandre Lautrette, Jean-Michel Constantin, Pierre-Emmanuel Charles, Cedric Daubin, Remi Coudroy, Jean Dellamonica, Laurent Argaud, Pierre Phelouzat, Damien Contou…

    Citation: Annals of Intensive Care 2020 10:74

    Content type: Research

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  26. The ongoing coronavirus disease 2019 (COVID-2019) pandemic has swept all over the world, posing a great pressure on critical care resources due to large number of patients needing critical care. Statements fro...

    Authors: You Shang, Chun Pan, Xianghong Yang, Ming Zhong, Xiuling Shang, Zhixiong Wu, Zhui Yu, Wei Zhang, Qiang Zhong, Xia Zheng, Ling Sang, Li Jiang, Jiancheng Zhang, Wei Xiong, Jiao Liu and Dechang Chen

    Citation: Annals of Intensive Care 2020 10:73

    Content type: Review

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  27. An amendment to this paper has been published and can be accessed via the original article.

    Authors: Florian Blanchard, Judith Charbit, Guillaume Van der Meersch, Benjamin Popoff, Adrien Picod, Regis Cohen, Frank Chemouni, Stephane Gaudry, Helene Bihan and Yves Cohen

    Citation: Annals of Intensive Care 2020 10:72

    Content type: Correction

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    The original article was published in Annals of Intensive Care 2020 10:58

  28. A recent increase in children admitted with hypotensive shock and fever in the context of the COVID-19 outbreak requires an urgent characterization and assessment of the involvement of SARS-CoV-2 infection. Th...

    Authors: Marion Grimaud, Julie Starck, Michael Levy, Clémence Marais, Judith Chareyre, Diala Khraiche, Marianne Leruez-Ville, Pierre Quartier, Pierre Louis Léger, Guillaume Geslain, Nada Semaan, Florence Moulin, Matthieu Bendavid, Sandrine Jean, Géraldine Poncelet, Sylvain Renolleau…

    Citation: Annals of Intensive Care 2020 10:69

    Content type: Research

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  29. Survival benefit from low tidal volume (VT) ventilation (LTVV) has been demonstrated for patients with acute respiratory distress syndrome (ARDS), and patients not having ARDS could also benefit from this strateg...

    Authors: Thais Dias Midega, Fernando A. Bozza, Flávia Ribeiro Machado, Helio Penna Guimarães, Jorge I. Salluh, Antonio Paulo Nassar Jr., Karina Normílio-Silva, Marcus J. Schultz, Alexandre Biasi Cavalcanti and Ary Serpa Neto

    Citation: Annals of Intensive Care 2020 10:68

    Content type: Research

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  30. Inappropriate ventilator assist plays an important role in the development of diaphragm dysfunction. Ventilator under-assist may lead to muscle injury, while over-assist may result in muscle atrophy. This prov...

    Authors: L. H. Roesthuis, J. G. van der Hoeven, H. W. H. van Hees, W.-J. M. Schellekens, J. Doorduin and L. M. A. Heunks

    Citation: Annals of Intensive Care 2020 10:67

    Content type: Research

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  31. Prone position (PP) is highly recommended in moderate-to-severe ARDS. However, the optimal duration of PP sessions remains unclear. We searched to evaluate the time required to obtain the maximum physiological...

    Authors: Sebastien Jochmans, Sandie Mazerand, Jonathan Chelly, Franck Pourcine, Oumar Sy, Nathalie Thieulot-Rolin, Olivier Ellrodt, Emmanuelle Mercier Des Rochettes, Gaël Michaud, Jean Serbource-Goguel, Christophe Vinsonneau, Ly Van Phach Vong and Mehran Monchi

    Citation: Annals of Intensive Care 2020 10:66

    Content type: Research

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  32. We performed a systematic review and meta-analysis of studies assessing the end-expiratory occlusion test (EEXPO test)-induced changes in cardiac output (CO) measured by any haemodynamic monitoring device, as ...

    Authors: Francesco Gavelli, Rui Shi, Jean-Louis Teboul, Danila Azzolina and Xavier Monnet

    Citation: Annals of Intensive Care 2020 10:65

    Content type: Research

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  33. Intravenous fluid administration should be considered as any other pharmacological prescription. There are three main indications: resuscitation, replacement, and maintenance. Moreover, the impact of fluid adm...

    Authors: Manu L. N. G. Malbrain, Thomas Langer, Djillali Annane, Luciano Gattinoni, Paul Elbers, Robert G. Hahn, Inneke De laet, Andrea Minini, Adrian Wong, Can Ince, David Muckart, Monty Mythen, Pietro Caironi and Niels Van Regenmortel

    Citation: Annals of Intensive Care 2020 10:64

    Content type: Review

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  34. No recommendation exists about the timing and setting for tracheal intubation and mechanical ventilation in septic shock.

    Authors: C. Darreau, F. Martino, M. Saint-Martin, S. Jacquier, J. F. Hamel, M. A. Nay, N. Terzi, G. Ledoux, F. Roche-Campo, L. Camous, F. Pene, T. Balzer, F. Bagate, J. Lorber, P. Bouju, C. Marois…

    Citation: Annals of Intensive Care 2020 10:62

    Content type: Research

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