Articles

Correction to: Serum sodium and intracranial pressure changes after desmopressin therapy in severe traumatic brain injury patients: a multi-centre cohort study

Following publication of the original article [1], we were notified that the collaborators’ names part of the “The TBI Collaborative” group has not been indexed in Pubmed. Below the collaborators names full list:

Authors: A. Harrois, J. R. Anstey, F. S. Taccone, A. A. Udy, G. Citerio, J. Duranteau, C. Ichai, R. Badenes, J. R. Prowle, A. Ercole, M. Oddo, A. Schneider, M. van der Jagt, S. Wolf, R. Helbok, D. W. Nelson…

IgM-enriched immunoglobulins (Pentaglobin) may improve the microcirculation in sepsis: a pilot randomized trial

Polyclonal or IgM-enriched immunoglobulins may be beneficial during sepsis as an adjuvant immunomodulatory therapy. We aimed to test whether the infusion of IgM-enriched immunoglobulins improves microvascular ...

Authors: Roberta Domizi, Erica Adrario, Elisa Damiani, Claudia Scorcella, Andrea Carsetti, Paolo Giaccaglia, Erika Casarotta, Vincenzo Gabbanelli, Simona Pantanetti, Elena Lamura, Silvia Ciucani and Abele Donati

“I had the feeling that I was trapped”: a bedside qualitative study of cognitive and affective attitudes toward noninvasive ventilation in patients with acute respiratory failure

Noninvasive ventilation (NIV) is the application of mechanical ventilation through a mask. It is used to treat certain forms of acute respiratory failure in intensive care units (ICU). NIV has clinical benefit...

Authors: Marina Iosifyan, Matthieu Schmidt, Amélie Hurbault, Julien Mayaux, Christian Delafosse, Marina Mishenko, Nathalie Nion, Alexandre Demoule and Thomas Similowski

Epidemiology, clinical features, and management of severe hypercalcemia in critically ill patients

Severe hypercalcemia (HCM) is a common reason for admission in intensive-care unit (ICU). This case series aims to describe the clinical and biological features, etiologies, treatments, and outcome associated ...

Authors: Cyril Mousseaux, Axelle Dupont, Cédric Rafat, Kenneth Ekpe, Etienne Ghrenassia, Lionel Kerhuel, Fanny Ardisson, Eric Mariotte, Virginie Lemiale, Benoît Schlemmer, Elie Azoulay and Lara Zafrani

Survey of non-resuscitation fluids administered during septic shock: a multicenter prospective observational study

The indication, composition and timing of administration of non-resuscitation fluid in septic shock have so far received little attention and accordingly the potential to reduce this source of fluid is unknown...

Authors: Anja Lindén-Søndersø, Mårten Jungner, Martin Spångfors, Mohammed Jan, Adam Oscarson, Sally Choi, Thomas Kander, Johan Undén, Donald Griesdale, John Boyd and Peter Bentzer

Outcome and prognostic factors of Pneumocystis jirovecii pneumonia in immunocompromised adults: a prospective observational study

Pneumocystis jirovecii pneumonia (PJP) remains a severe disease associated with high rates of invasive mechanical ventilation (MV) and mortality. The objectives of this study were to assess early risk factors for...

Authors: Benjamin Jean Gaborit, Benoit Tessoulin, Rose-Anne Lavergne, Florent Morio, Christine Sagan, Emmanuel Canet, Raphael Lecomte, Paul Leturnier, Colin Deschanvres, Lydie Khatchatourian, Nathalie Asseray, Charlotte Garret, Michael Vourch, Delphine Marest, François Raffi, David Boutoille…

Intra-aortic balloon pump does not influence cerebral hemodynamics and neurological outcomes in high-risk cardiac patients undergoing cardiac surgery: an analysis of the IABCS trial

The intra-aortic balloon pump (IABP) is often used in high-risk patients undergoing cardiac surgery to improve coronary perfusion and decrease afterload. The effects of the IABP on cerebral hemodynamics are un...

Authors: Juliana R. Caldas, Ronney B. Panerai, Edson Bor-Seng-Shu, Graziela S. R. Ferreira, Ligia Camara, Rogério H. Passos, Angela M. Salinet, Daniel S. Azevedo, Marcelo de-Lima-Oliveira, Filomena R. B. G. Galas, Julia T. Fukushima, Ricardo Nogueira, Fabio S. Taccone, Giovanni Landoni, Juliano P. Almeida, Thompson G. Robinson…

Effect of nitric oxide on postoperative acute kidney injury in patients who underwent cardiopulmonary bypass: a systematic review and meta-analysis with trial sequential analysis

The effect of nitric oxide (NO) on renal function is controversial in critical illness. We performed a systematic meta-analysis and trial sequential analysis to determine the effect of NO gas on renal function...

Authors: Jie Hu, Stefano Spina, Francesco Zadek, Nikolay O. Kamenshchikov, Edward A. Bittner, Juan Pedemonte and Lorenzo Berra

Estimated dead space fraction and the ventilatory ratio are associated with mortality in early ARDS

Indirect indices for measuring impaired ventilation, such as the estimated dead space fraction and the ventilatory ratio, have been shown to be independently associated with an increased risk of mortality. Thi...

Authors: Luis Morales-Quinteros, Marcus J. Schultz, Josep Bringué, Carolyn S. Calfee, Marta Camprubí, Olaf L. Cremer, Janneke Horn, Tom van der Poll, Pratik Sinha, Antonio Artigas and Lieuwe D. Bos

Targeted temperature management guided by the severity of hyperlactatemia for out-of-hospital cardiac arrest patients: a post hoc analysis of a nationwide, multicenter prospective registry

The International Liaison Committee on Resuscitation guidelines recommend target temperature management (TTM) between 32 and 36 °C for patients after out-of-hospital cardiac arrest, but did not indicate patien...

Authors: Tomoya Okazaki, Toru Hifumi, Kenya Kawakita and Yasuhiro Kuroda

Healthcare trajectories before and after critical illness: population-based insight on diverse patients clusters

The post intensive care syndrome (PICS) gathers various disabilities, associated with a substantial healthcare use. However, patients’ comorbidities and active medical conditions prior to intensive care unit (...

Authors: Youenn Jouan, Leslie Grammatico-Guillon, Noémie Teixera, Claire Hassen-Khodja, Christophe Gaborit, Charlotte Salmon-Gandonnière, Antoine Guillon and Stephan Ehrmann

Prediction of mortality in adult patients with sepsis using six biomarkers: a systematic review and meta-analysis

Angiopoietin-1 (Ang-1) and 2 (Ang-2), high mobility group box 1 (HMGB1), soluble receptor for advanced glycation endproducts (sRAGE), soluble triggering receptor expressed on myeloid cells 1 (sTREM1), and solu...

Authors: Andreas Pregernig, Mattia Müller, Ulrike Held and Beatrice Beck-Schimmer

Use of ultrasound-measured internal jugular vein collapsibility index to determine static intracardiac pressures in patients with presumed pulmonary hypertension

Bedside ultrasound helps to estimate volume status in critically ill patients and has traditionally relied on diameter, respiratory variation, and collapsibility of the inferior vena cava (IVC) to reflect flui...

Authors: Raj Parikh, Matthew Spring, Janice Weinberg, Christine C. Reardon and Harrison W. Farber

Impact of a multidisciplinary care bundle for necrotizing skin and soft tissue infections: a retrospective cohort study

Necrotizing skin and soft tissue infections (NSTIs) require both prompt medical and surgical treatment. The coordination of multiple urgent interventions by care bundles has improved outcome in other settings....

Authors: Tomas Urbina, Camille Hua, Emilie Sbidian, Romain Bosc, Françoise Tomberli, Raphael Lepeule, Jean-Winoc Decousser, Armand Mekontso Dessap, Olivier Chosidow and Nicolas de Prost

Effects of high-flow nasal cannula and non-invasive ventilation on inspiratory effort in hypercapnic patients with chronic obstructive pulmonary disease: a preliminary study

Non-invasive ventilation (NIV) is preferred as the initial ventilatory support to treat acute hypercapnic respiratory failure in patients with chronic obstructive pulmonary disease (COPD). High-flow nasal cann...

Authors: Nuttapol Rittayamai, Prapinpa Phuangchoei, Jamsak Tscheikuna, Nattakarn Praphruetkit and Laurent Brochard

Urgent need for a randomized controlled trial with only septic patients!

Authors: Sébastien Redant, Matthieu Legrand, Yael Langman, Alejandra Garcia Aguilar, Keitiane Kaefer, David De Bels, Rachid Attou, Kianoush Kashani and Patrick M. Honore

Impact of natural light exposure on delirium burden in adult patients receiving invasive mechanical ventilation in the ICU: a prospective study

To determine whether potential exposure to natural light via windows is associated with reduced delirium burden in critically ill patients admitted to the ICU in a single room.

Authors: Roland Smonig, Eric Magalhaes, Lila Bouadma, Olivier Andremont, Etienne de Montmollin, Fatiah Essardy, Bruno Mourvillier, Jordane Lebut, Claire Dupuis, Mathilde Neuville, Mathilde Lermuzeaux, Jean-François Timsit and Romain Sonneville

Growth differentiation factor 15 and early prognosis after out-of-hospital cardiac arrest

Growth differentiation factor 15 (GDF-15) is an inflammatory cytokine released in response to tissue injury. It has prognostic value in cardiovascular diseases and other acute and chronic conditions. Here, we ...

Authors: Ferran Rueda, Germán Cediel, Cosme García-García, Júlia Aranyó, Marta González-Lopera, M. Cruz Aranda Nevado, Judith Serra Gregori, Teresa Oliveras, Carlos Labata, Marc Ferrer, Nabil El Ouaddi and Antoni Bayés-Genís

Use of MIRUS™ for MAC-driven application of isoflurane, sevoflurane, and desflurane in postoperative ICU patients: a randomized controlled trial

The MIRUS™ (TIM, Koblenz, Germany) is an electronical gas delivery system, which offers an automated MAC (minimal alveolar concentration)-driven application of isoflurane, sevoflurane, or desflurane, and can b...

Authors: Martin Bellgardt, Adrian Iustin Georgevici, Mitja Klutzny, Dominik Drees, Andreas Meiser, Philipp Gude, Heike Vogelsang, Thomas Peter Weber and Jennifer Herzog-Niescery

Changes in dynamic arterial elastance induced by volume expansion and vasopressor in the operating room: a prospective bicentre study

Dynamic arterial elastance (Eadyn), defined as the ratio between pulse pressure variations and stroke volume variations, has been proposed to assess functional arterial load. We evaluated the evolution of Eady...

Authors: Hugues de Courson, Philippe Boyer, Romain Grobost, Romain Lanchon, Musa Sesay, Karine Nouette-Gaulain, Emmanuel Futier and Matthieu Biais

Evaluation of least significant changes of pulse contour analysis-derived parameters

Many maneuvers assessing fluid responsiveness (minifluid challenge, lung recruitment maneuver, end-expiratory occlusion test, passive leg raising) are considered as positive when small variations in cardiac in...

Authors: Hugues de Courson, Loic Ferrer, Grégoire Cane, Eric Verchère, Musa Sesay, Karine Nouette-Gaulain and Matthieu Biais

Management of severe asthma exacerbation: guidelines from the Société Française de Médecine d’Urgence, the Société de Réanimation de Langue Française and the French Group for Pediatric Intensive Care and Emergencies

The French Emergency Medicine Society, the French Intensive Care Society and the Pediatric Intensive Care and Emergency Medicine French-Speaking Group edited guidelines on severe asthma exacerbation (SAE) in a...

Authors: Philippe Le Conte, Nicolas Terzi, Guillaume Mortamet, Fekri Abroug, Guillaume Carteaux, Céline Charasse, Anthony Chauvin, Xavier Combes, Stéphane Dauger, Alexandre Demoule, Thibaut Desmettre, Stephan Ehrmann, Bénédicte Gaillard-Le Roux, Valérie Hamel, Boris Jung, Sabrina Kepka…

Physiological effects of high-flow oxygen in tracheostomized patients

High-flow oxygen therapy via nasal cannula (HFOT_NASAL) increases airway pressure, ameliorates oxygenation and reduces work of breathing. High-flow oxygen can be delivered through tracheostomy (HFOT_TRACHEAL), but ...

Authors: Daniele Natalini, Domenico L. Grieco, Maria Teresa Santantonio, Lucrezia Mincione, Flavia Toni, Gian Marco Anzellotti, Davide Eleuteri, Pierluigi Di Giannatale, Massimo Antonelli and Salvatore Maurizio Maggiore

Respiratory variations of inferior vena cava fail to predict fluid responsiveness in mechanically ventilated patients with isolated left ventricular dysfunction

Respiratory variation of inferior vena cava is problematic in predicting fluid responsiveness in patients with right ventricular dysfunction. However, its effectiveness in patients with isolated left ventricul...

Authors: Hongmin Zhang, Qing Zhang, Xiukai Chen, Xiaoting Wang and Dawei Liu

When one cannot see the forest for the trees: femoral dP/dt_max, LVEF and pulse pressure in critically ill patients

Authors: S. Vaquer, D. Chemla and X. Monnet

Assessing left ventricular systolic function with ejection fraction: using a double-edged knife as a hammer

Authors: M. Ignacio Monge García, Maurizio Cecconi and Michael R. Pinsky

Direct admission to the intensive care unit from the emergency department and mortality in critically ill hematology patients

The aim of this study was to assess the benefit of direct ICU admission from the emergency department (ED) compared to admission from wards, in patients with hematological malignancies requiring critical care.

Authors: Olivier Peyrony, Sylvie Chevret, Anne-Pascale Meert, Pierre Perez, Achille Kouatchet, Frédéric Pène, Djamel Mokart, Virginie Lemiale, Alexandre Demoule, Martine Nyunga, Fabrice Bruneel, Christine Lebert, Dominique Benoit, Adrien Mirouse and Elie Azoulay

Morpho-functional evaluation of lung aeration as a marker of sickle-cell acute chest syndrome severity in the ICU: a prospective cohort study

Acute chest syndrome (ACS) is the main cause of morbi-mortality in patients with sickle-cell disease in the intensive care unit (ICU). ACS definition encompasses many types of lung damage, making early detecti...

Authors: Marc Garnier, El Mahdi Hafiani, Charlotte Arbelot, Clarisse Blayau, Vincent Labbe, Katia Stankovic-Stojanovic, François Lionnet, Francis Bonnet, Jean-Pierre Fulgencio, Muriel Fartoukh and Christophe Quesnel

Early prediction of noninvasive ventilation failure in COPD patients: derivation, internal validation, and external validation of a simple risk score

Early identification of noninvasive ventilation (NIV) failure is a promising strategy for reducing mortality in chronic obstructive pulmonary disease (COPD) patients. However, a risk-scoring system is lacking.

Authors: Jun Duan, Shengyu Wang, Ping Liu, Xiaoli Han, Yao Tian, Fan Gao, Jing Zhou, Junhuan Mou, Qian Qin, Jingrong Yu, Linfu Bai, Lintong Zhou and Rui Zhang

Correction to: Recruiting the microcirculation in septic shock

After publication of the original article [1], we were notified that an author’s name has been incorrectly spelled. Author’s first name is Hafid and the family name is Ait-Oufella (with a hyphen between Ait an...

Authors: Matthieu Legrand, Daniel De Backer, François Dépret and Hafid Ait-Oufella

Nephrotoxic drug burden among 1001 critically ill patients: impact on acute kidney injury

Nephrotoxic drug prescription may contribute to acute kidney injury (AKI) occurrence and worsening among critically ill patients and thus to associated morbidity and mortality. The objectives of this study wer...

Authors: Stephan Ehrmann, Julie Helms, Aurélie Joret, Laurent Martin-Lefevre, Jean-Pierre Quenot, Jean-Etienne Herbrecht, Dalila Benzekri-Lefevre, René Robert, Arnaud Desachy, Fréderic Bellec, Gaëtan Plantefeve, Anne Bretagnol, Auguste Dargent, Jean-Claude Lacherade, Ferhat Meziani, Bruno Giraudeau…

Withholding and withdrawing life-support in adults in emergency care: joint position paper from the French Intensive Care Society and French Society of Emergency Medicine

For many patients, notably among elderly nursing home residents, no plans about end-of-life decisions and palliative care are made. Consequently, when these patients experience life-threatening events, decisio...

Authors: Jean Reignier, Anne-Laure Feral-Pierssens, Thierry Boulain, Françoise Carpentier, Pierrick Le Borgne, Denis Del Nista, Gilles Potel, Sandrine Dray, Delphine Hugenschmitt, Alexandra Laurent, Agnès Ricard-Hibon, Thierry Vanderlinden and Tahar Chouihed

Accuracy of P0.1 measurements performed by ICU ventilators: a bench study

Occlusion pressure at 100 ms (P0.1), defined as the negative pressure measured 100 ms after the initiation of an inspiratory effort performed against a closed respiratory circuit, has been shown to be well cor...

Authors: François Beloncle, Lise Piquilloud, Pierre-Yves Olivier, Alice Vuillermoz, Elise Yvin, Alain Mercat and Jean-Christophe Richard

Association of endothelial and glycocalyx injury biomarkers with fluid administration, development of acute kidney injury, and 90-day mortality: data from the FINNAKI observational study

Injury to endothelium and glycocalyx predisposes to vascular leak, which may subsequently lead to increased fluid requirements and worse outcomes. In this post hoc study of the prospective multicenter observat...

Authors: Nina Inkinen, Ville Pettilä, Päivi Lakkisto, Anne Kuitunen, Sakari Jukarainen, Stepani Bendel, Outi Inkinen, Tero Ala-Kokko and Suvi T. Vaara

Recruiting the microcirculation in septic shock

Authors: Matthieu Legrand, Daniel De Backer, François Dépret and Hafid Ait-Oufella

Predictors of successful separation from high-flow nasal oxygen therapy in patients with acute respiratory failure: a retrospective monocenter study

High-flow nasal oxygen therapy (HFOT) is a promising first-line therapy for acute respiratory failure. However, its weaning has never been investigated and could lead to unnecessary prolonged intensive-care un...

Authors: Maeva Rodriguez, Arnaud W. Thille, Florence Boissier, Anne Veinstein, Delphine Chatellier, René Robert, Sylvain Le Pape, Jean-Pierre Frat and Remi Coudroy

Association between potassium concentrations, variability and supplementation, and in-hospital mortality in ICU patients: a retrospective analysis

Serum potassium concentrations are commonly between 3.5 and 5.0 mmol/l. Standardised protocols for potassium range and supplementation in the ICU are lacking. The purpose of this retrospective analysis of ICU ...

Authors: Lilian Jo Engelhardt, Felix Balzer, Michael C. Müller, Julius J. Grunow, Claudia D. Spies, Kenneth B. Christopher, Steffen Weber-Carstens and Tobias Wollersheim

Serum sodium and intracranial pressure changes after desmopressin therapy in severe traumatic brain injury patients: a multi-centre cohort study

In traumatic brain injury (TBI) patients desmopressin administration may induce rapid decreases in serum sodium and increase intracranial pressure (ICP).

Authors: A. Harrois, J. R. Anstey, F. S. Taccone, A. A. Udy, G. Citerio, J. Duranteau, C. Ichai, R. Badenes, J. R. Prowle, A. Ercole, M. Oddo, A. Schneider, M. van der Jagt, S. Wolf, R. Helbok, D. W. Nelson…

High-flow nasal cannula therapy: clinical practice in intensive care units

Despite the extensive use of high-flow nasal cannula (HFNC) therapy in intensive care units (ICU) for acute respiratory failure (ARF), its daily clinical practice has not been assessed. We designed a regional ...

Authors: Emmanuel Besnier, Sinad Hobeika, Saad NSeir, Fabien Lambiotte, Damien Du Cheyron, Bertrand Sauneuf, Benoit Misset, Fabienne Tamion, Guillaume Schnell, Jack Richecoeur, Julien Maizel and Christophe Girault

Impact of increased mean arterial pressure on skin microcirculatory oxygenation in vasopressor-requiring septic patients: an interventional study

Heterogeneity of microvascular blood flow leading to tissue hypoxia is a common finding in patients with septic shock. It may be related to suboptimal systemic perfusion pressure and lead to organ failure. Map...

Authors: Sigita Kazune, Anastasija Caica, Einars Luksevics, Karina Volceka and Andris Grabovskis

Acute respiratory failure and mechanical ventilation in cardiogenic shock complicating acute myocardial infarction in the USA, 2000–2014

There are limited epidemiological data on acute respiratory failure (ARF) in cardiogenic shock complicating acute myocardial infarction (AMI-CS). This study sought to evaluate the prevalence and outcomes of AR...

Authors: Saraschandra Vallabhajosyula, Kianoush Kashani, Shannon M. Dunlay, Shashaank Vallabhajosyula, Saarwaani Vallabhajosyula, Pranathi R. Sundaragiri, Bernard J. Gersh, Allan S. Jaffe and Gregory W. Barsness

Hyperchloremia is not associated with AKI or death in septic shock patients: results of a post hoc analysis of the “HYPER2S” trial

Recent data suggest that hyperchloremia induced by fluid resuscitation is associated with acute kidney injury (AKI) and mortality, particularly in sepsis. Experimental studies showed that hyperchloremia could ...

Authors: Morgane Commereuc, Camille Nevoret, Peter Radermacher, Sandrine Katsahian, Pierre Asfar and Frédérique Schortgen

Incidence and impact of sepsis on long-term outcomes after subarachnoid hemorrhage: a prospective observational study

Aneurysmal subarachnoid hemorrhage (SAH) is an acute cerebrovascular disease associated with high mortality and long-term functional impairment among survivors. Systemic inflammatory responses after acute inju...

Authors: Bruno Gonçalves, Pedro Kurtz, Ricardo Turon, Thayana Santos, Marco Prazeres, Cassia Righy and Fernando Augusto Bozza

Animal ICU… Why not also use the existing veterinary ICUs?

Authors: Florent Baudin, Céline Pouzot-Nevoret, Vanessa Louzier, Isabelle Goy-Thollot, Anthony Barthélemy, Stéphane Junot, Jeanne-Marie Bonnet-Garin and Bernard Allaouchiche

Diagnosis and management of metabolic acidosis: guidelines from a French expert panel

Metabolic acidosis is a disorder frequently encountered in emergency medicine and intensive care medicine. As literature has been enriched with new data concerning the management of metabolic acidosis, the Fre...

Authors: Boris Jung, Mikaël Martinez, Yann-Erick Claessens, Michaël Darmon, Kada Klouche, Alexandre Lautrette, Jacques Levraut, Eric Maury, Mathieu Oberlin, Nicolas Terzi, Damien Viglino, Youri Yordanov, Pierre-Géraud Claret and Naïke Bigé

Initial management of diabetic ketoacidosis and prognosis according to diabetes type: a French multicentre observational retrospective study

Guidelines for the management of diabetic ketoacidosis (DKA) do not consider the type of underlying diabetes. We aimed to compare the occurrence of metabolic adverse events and the recovery time for DKA accord...

Authors: Adrien Balmier, Fadia Dib, Arnaud Serret-Larmande, Etienne De Montmollin, Victorine Pouyet, Benjamin Sztrymf, Bruno Megarbane, Abirami Thiagarajah, Didier Dreyfuss, Jean-Damien Ricard and Damien Roux

Is immunosuppression status a risk factor for noninvasive ventilation failure in patients with acute hypoxemic respiratory failure? A post hoc matched analysis

Recent European/American guidelines recommend noninvasive ventilation (NIV) as a first-line therapy to manage acute hypoxemic respiratory failure in immunocompromised patients. By contrast, NIV may have delete...

Authors: Rémi Coudroy, Tài Pham, Florence Boissier, René Robert, Jean-Pierre Frat and Arnaud W. Thille

Information conveyed by electrical diaphragmatic activity during unstressed, stressed and assisted spontaneous breathing: a physiological study

The electrical activity of the crural diaphragm (Eadi), a surrogate of respiratory drive, can now be measured at the bedside in mechanically ventilated patients with a specific catheter. The expected range of ...

Authors: Lise Piquilloud, François Beloncle, Jean-Christophe M. Richard, Jordi Mancebo, Alain Mercat and Laurent Brochard

Electrical impedance tomography during spontaneous breathing trials and after extubation in critically ill patients at high risk for extubation failure: a multicenter observational study

This study aims to assess the changes in lung aeration and ventilation during the first spontaneous breathing trial (SBT) and after extubation in a population of patients at risk of extubation failure.

Authors: Federico Longhini, Jessica Maugeri, Cristina Andreoni, Chiara Ronco, Andrea Bruni, Eugenio Garofalo, Corrado Pelaia, Camilla Cavicchi, Sergio Pintaudi and Paolo Navalesi

Complete blood count in acute kidney injury prediction: a narrative review

Acute kidney injury (AKI) is a complex syndrome defined by a decrease in renal function. The incidence of AKI has raised in the past decades, and it is associated with negative impact in patient outcomes in th...

Authors: Joana Gameiro and José António Lopes