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  1. Research

    Duration of acute kidney injury in critically ill patients

    Duration of acute kidney injury (AKI) has been recognized a risk factor for adverse outcomes following AKI. We sought to examine the relationship of AKI duration and recurrent AKI with short-term outcomes in c...

    Christine K. Federspiel, Theis S. Itenov, Kala Mehta, Raymond K. Hsu, Morten H. Bestle and Kathleen D. Liu

    Annals of Intensive Care 2018 8:30

    Published on: 23 February 2018

  2. Review

    Impaired aspirin-mediated platelet function inhibition in resuscitated patients with acute myocardial infarction treated with therapeutic hypothermia: a prospective, observational, non-randomized single-centre study

    The majority of resuscitated patients present with underlying cardiac disease, and out of these myocardial infarction is most common. Immediate interventional treatment is recommended and routinely requires du...

    Florian Prüller, Oliver Leopold Milke, Lukasz Bis, Friedrich Fruhwald, Daniel Scherr, Philipp Eller, Sascha Pätzold, Siegfried Altmanninger-Sock, Peter Rainer, Jolanta Siller-Matula and Dirk von Lewinski

    Annals of Intensive Care 2018 8:28

    Published on: 21 February 2018

  3. Research

    Use of speckle-tracking strain in preload-dependent patients, need for cautious interpretation!

    In critical patients, left ventricular ejection fraction and fractional shortening are used to reflect left ventricular systolic function. An emerging technique, two-dimensional-strain echocardiography, allows...

    C. Nafati, M. Gardette, M. Leone, L. Reydellet, V. Blasco, A. Lannelongue, F. Sayagh, S. Wiramus, F. Antonini, J. Albanèse and L. Zieleskiewicz

    Annals of Intensive Care 2018 8:29

    Published on: 21 February 2018

  4. Research

    Fluid therapy and outcome: a prospective observational study in 65 German intensive care units between 2010 and 2011

    Outcome data on fluid therapy in critically ill patients from randomised controlled trials may be different from data obtained by observational studies under “real-life” conditions. We conducted this prospecti...

    Christian Ertmer, Bernhard Zwißler, Hugo Van Aken, Michael Christ, Fabian Spöhr, Axel Schneider, Robert Deisz and Matthias Jacob

    Annals of Intensive Care 2018 8:27

    Published on: 17 February 2018

  5. Research

    Lung volumes and lung volume recruitment in ARDS: a comparison between supine and prone position

    The use of positive end-expiratory pressure (PEEP) and prone position (PP) is common in the management of severe acute respiratory distress syndrome patients (ARDS). We conducted this study to analyze the vari...

    Hernan Aguirre-Bermeo, Marta Turella, Maddalena Bitondo, Juan Grandjean, Stefano Italiano, Olimpia Festa, Indalecio Morán and Jordi Mancebo

    Annals of Intensive Care 2018 8:25

    Published on: 14 February 2018

  6. Research

    Acute kidney injury epidemiology, risk factors, and outcomes in critically ill patients 16–25 years of age treated in an adult intensive care unit

    Most studies of acute kidney injury (AKI) have focused on older adults, and little is known about AKI in young adults (16–25 years) that are cared for in an adult intensive care unit (ICU). We analyzed data fr...

    Dana Y. Fuhrman, Sandra Kane-Gill, Stuart L. Goldstein, Priyanka Priyanka and John A. Kellum

    Annals of Intensive Care 2018 8:26

    Published on: 14 February 2018

  7. Research

    Sodium lactate improves renal microvascular thrombosis compared to sodium bicarbonate and 0.9% NaCl in a porcine model of endotoxic shock: an experimental randomized open label controlled study

    Sodium lactate seemed to improve fluid balance and avoid fluid overload. The objective of this study was to determine if these beneficial effects can be at least partly explained by an improvement in dissemina...

    Thibault Duburcq, Arthur Durand, Antoine Tournoys, Viviane Gnemmi, Valery Gmyr, François Pattou, Mercedes Jourdain, Fabienne Tamion, Emmanuel Besnier, Sebastien Préau, Erika Parmentier-Decrucq, Daniel Mathieu, Julien Poissy and Raphaël Favory

    Annals of Intensive Care 2018 8:24

    Published on: 14 February 2018

  8. Research

    Plasma microRNAs levels are different between pulmonary and extrapulmonary ARDS patients: a clinical observational study

    Mesenchymal stem cells (MSC) obviously alleviate the damage of the structure and function of pulmonary vascular endothelial cells (VEC). The therapeutic effects of MSC are significantly different between pulmo...

    Yi Zheng, Song-qiao Liu, Qin Sun, Jian-feng Xie, Jing-yuan Xu, Qing Li, Chun Pan, Ling Liu and Ying-zi Huang

    Annals of Intensive Care 2018 8:23

    Published on: 13 February 2018

  9. Review

    Assessment of fluid responsiveness in spontaneously breathing patients: a systematic review of literature

    Patients who increase stoke volume or cardiac index more than 10 or 15% after a fluid challenge are usually considered fluid responders. Assessment of fluid responsiveness prior to volume expansion is critical...

    Renato Carneiro de Freitas Chaves, Thiago Domingos Corrêa, Ary Serpa Neto, Bruno de Arruda Bravim, Ricardo Luiz Cordioli, Fabio Tanzillo Moreira, Karina Tavares Timenetsky and Murillo Santucci Cesar de Assunção

    Annals of Intensive Care 2018 8:21

    Published on: 9 February 2018

  10. Research

    Delayed cerebral thrombosis complicating pneumococcal meningitis: an autopsy study

    Delayed cerebral thrombosis (DCT) is a devastating cerebrovascular complication in patients with excellent initial recovery of pneumococcal meningitis. The aetiology is unknown, but direct bacterial invasion, ...

    Joo-Yeon Engelen-Lee, Matthijs C. Brouwer, Eleonora Aronica and Diederik van de Beek

    Annals of Intensive Care 2018 8:20

    Published on: 9 February 2018

  11. Research

    The effect of a medication reconciliation program in two intensive care units in the Netherlands: a prospective intervention study with a before and after design

    Medication errors occur frequently in the intensive care unit (ICU) and during care transitions. Chronic medication is often temporarily stopped at the ICU. Unfortunately, when the patient improves, the restar...

    Liesbeth B. E. Bosma, Nicole G. M. Hunfeld, Rogier A. M. Quax, Edmé Meuwese, Piet H. G. J. Melief, Jasper van Bommel, SiokSwan Tan, Maaike J. van Kranenburg and Patricia M. L. A. van den Bemt

    Annals of Intensive Care 2018 8:19

    Published on: 7 February 2018

  12. Research

    Physiological predictors of respiratory and cough assistance needs after extubation

    Identifying patients at high risk of post-extubation acute respiratory failure requiring respiratory or mechanical cough assistance remains challenging. Here, our primary aim was to evaluate the accuracy of ea...

    Nicolas Terzi, Frédéric Lofaso, Romain Masson, Pascal Beuret, Hervé Normand, Edith Dumanowski, Line Falaize, Bertrand Sauneuf, Cédric Daubin, Jennifer Brunet, Djillali Annane, Jean-Jacques Parienti and David Orlikowski

    Annals of Intensive Care 2018 8:18

    Published on: 5 February 2018

  13. Research

    Pharmacogenomic biomarkers do not predict response to drotrecogin alfa in patients with severe sepsis

    To explore potential design for pharmacogenomics trials in sepsis, we investigate the interaction between pharmacogenomic biomarkers and response to drotrecogin alfa (activated) (DrotAA). This trial was desig...

    Djillali Annane, Jean-Paul Mira, Lorraine B. Ware, Anthony C. Gordon, Charles J. Hinds, David C. Christiani, Jonathan Sevransky, Kathleen Barnes, Timothy G. Buchman, Patrick J. Heagerty, Robert Balshaw, Nadia Lesnikova, Karen de Nobrega, Hugh F. Wellman, Mauricio Neira, Alexandra D. J. Mancini…

    Annals of Intensive Care 2018 8:16

    Published on: 31 January 2018

  14. Research

    Epidemiology, causes, evolution and outcome in a single-center cohort of 1116 critically ill patients with hypoxic hepatitis

    Hypoxic hepatitis (HH) is a type of acute hepatic injury that is histologically characterized by centrilobular liver cell necrosis and that is caused by insufficient oxygen delivery to the hepatocytes. Typical...

    Astrid Van den broecke, Laura Van Coile, Alexander Decruyenaere, Kirsten Colpaert, Dominique Benoit, Hans Van Vlierberghe and Johan Decruyenaere

    Annals of Intensive Care 2018 8:15

    Published on: 30 January 2018

  15. Research

    Reliability of respiratory pressure measurements in ventilated and non-ventilated patients in ICU: an observational study

    Assessment of maximum respiratory pressures is a common practice in intensive care because it can predict the success of weaning from ventilation. However, the reliability of measurements through an intubation...

    Clément Medrinal, Guillaume Prieur, Yann Combret, Aurora Robledo Quesada, Tristan Bonnevie, Francis Edouard Gravier, Eric Frenoy, Olivier Contal and Bouchra Lamia

    Annals of Intensive Care 2018 8:14

    Published on: 30 January 2018

  16. Research

    Transcutaneous electromyographic respiratory muscle recordings to quantify patient–ventilator interaction in mechanically ventilated children

    To explore the feasibility of transcutaneous electromyographic respiratory muscle recordings to automatically quantify the synchronicity of patient–ventilator interaction in the pediatric intensive care unit.

    Alette A. Koopman, Robert G. T. Blokpoel, Leo A. van Eykern, Frans H. C. de Jongh, Johannes G. M. Burgerhof and Martin C. J. Kneyber

    Annals of Intensive Care 2018 8:12

    Published on: 24 January 2018

  17. Research

    Comparison between a nurse-led weaning protocol and weaning based on physician’s clinical judgment in tracheostomized critically ill patients: a pilot randomized controlled clinical trial

    Weaning protocols expedite extubation in mechanically ventilated patients, yet the literature investigating the application in tracheostomized patients remains scarce. The primary objective of this parallel ra...

    Nazzareno Fagoni, Simone Piva, Elena Peli, Fabio Turla, Elisabetta Pecci, Livio Gualdoni, Bertilla Fiorese, Frank Rasulo and Nicola Latronico

    Annals of Intensive Care 2018 8:11

    Published on: 22 January 2018

  18. Research

    The host response in critically ill sepsis patients on statin therapy: a prospective observational study

    Statins can exert pleiotropic anti-inflammatory, vascular protective and anticoagulant effects, which in theory could improve the dysregulated host response during sepsis. We aimed to determine the association...

    Maryse A. Wiewel, Brendon P. Scicluna, Lonneke A. van Vught, Arie J. Hoogendijk, Aeilko H. Zwinderman, René Lutter, Janneke Horn, Olaf L. Cremer, Marc J. Bonten, Marcus J. Schultz and Tom van der Poll

    Annals of Intensive Care 2018 8:9

    Published on: 18 January 2018

  19. Research

    Stool cultures at the ICU: get rid of it!

    Stool cultures for Campylobacter, Salmonella and Shigella and/or Yersinia spp. are frequently ordered in critically ill patients with diarrhea. The aim of this study is to analyze the diagnostic yield in a large ...

    Carolin F. Manthey, Darja Dranova, Martin Christner, Laura Berneking, Stefan Kluge, Ansgar W. Lohse and Valentin Fuhrmann

    Annals of Intensive Care 2018 8:10

    Published on: 18 January 2018

  20. Research

    Response to different furosemide doses predicts AKI progression in ICU patients with elevated plasma NGAL levels

    Furosemide responsiveness (FR) is determined by urine output after furosemide administration and has recently been evaluated as a furosemide stress test (FST) for predicting severe acute kidney injury (AKI) pr...

    Ryo Matsuura, Yohei Komaru, Yoshihisa Miyamoto, Teruhiko Yoshida, Kohei Yoshimoto, Rei Isshiki, Kengo Mayumi, Tetsushi Yamashita, Yoshifumi Hamasaki, Masaomi Nangaku, Eisei Noiri, Naoto Morimura and Kent Doi

    Annals of Intensive Care 2018 8:8

    Published on: 17 January 2018

  21. Research

    Thromboelastography-based anticoagulation management during extracorporeal membrane oxygenation: a safety and feasibility pilot study

    There is no consensus on the management of anticoagulation during extracorporeal membrane oxygenation (ECMO). ECMO is currently burdened by a high rate of hemostatic complications, possibly associated with ina...

    Mauro Panigada, Giacomo E. Iapichino, Matteo Brioni, Giovanna Panarello, Alessandro Protti, Giacomo Grasselli, Giovanna Occhipinti, Cristina Novembrino, Dario Consonni, Antonio Arcadipane, Luciano Gattinoni and Antonio Pesenti

    Annals of Intensive Care 2018 8:7

    Published on: 16 January 2018

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