Articles

Prevalence and risk factors of hemodynamic instability associated with preload-dependence during continuous renal replacement therapy in a prospective observational cohort of critically ill patients

Hemodynamic instability is a frequent complication of continuous renal replacement therapy (CRRT). Postural tests (i.e., passive leg raising in the supine position or Trendelenburg maneuver in the prone positi...

Authors: Guillaume Chazot, Laurent Bitker, Mehdi Mezidi, Nader Chebib, Paul Chabert, Louis Chauvelot, Laure Folliet, Guillaume David, Judith Provoost, Hodane Yonis and Jean-Christophe Richard

The Ockham’s razor for estimating the needs of ICU beds during a pandemic

It is possible to monitor an epidemic evolution by plotting the number of patients, or its log-transform, as a function of time. However, these representations do not allow quick identifications of significant...

Authors: Pierre Squara

Correction to: Elevated plasma IL-6 and CRP levels are associated with adverse clinical outcomes and death in critically ill SARS-CoV-2 patients: infammatory response of SARS-CoV-2 patients

An amendment to this paper has been published and can be accessed via the original article.

Authors: Jean-Rémi Lavillegrand, Marc Garnier, Agathe Spaeth, Nathalie Mario, Geofroy Hariri, Antoine Pilon, Enora Berti, Fabienne Fieux, Sara Thietart, Tomas Urbina, Matthieu Turpin, Lucie Darrivere, Muriel Fartoukh, Franck Verdonk, Guillaume Dumas, Alain Tedgui…

Protective ventilation and outcomes of critically ill patients with COVID-19: a cohort study

Approximately 5% of COVID-19 patients develop respiratory failure and need ventilatory support, yet little is known about the impact of mechanical ventilation strategy in COVID-19. Our objective was to describ...

Authors: Juliana C. Ferreira, Yeh-Li Ho, Bruno Adler Maccagnan Pinheiro Besen, Luiz Marcelo Sa Malbouisson, Leandro Utino Taniguchi, Pedro Vitale Mendes, Eduardo Leite Vieira Costa, Marcelo Park, Renato Daltro-Oliveira, Roberta M. L. Roepke, Joao M. Silva-Jr, Maria Jose Carvalho Carmona and Carlos R. R. Carvalho

Short-term health-related quality of life, physical function and psychological consequences of severe COVID-19

Survivors of severe COVID-19 are at risk of impaired health-related quality of life (HRQoL) and persistent physical and psychological disability after ICU and hospital discharge. The subsequent social burden i...

Authors: Luca Carenzo, Alessandro Protti, Francesca Dalla Corte, Romina Aceto, Giacomo Iapichino, Angelo Milani, Alessandro Santini, Chiara Chiurazzi, Michele Ferrari, Enrico Heffler, Claudio Angelini, Alessio Aghemo, Michele Ciccarelli, Arturo Chiti, Theodore J. Iwashyna, Margaret S. Herridge…

Mental health and stress among ICU healthcare professionals in France according to intensity of the COVID-19 epidemic

We investigated the impact of the COVID-19 crisis on mental health of professionals working in the intensive care unit (ICU) according to the intensity of the epidemic in France.

Authors: Alexandra Laurent, Alicia Fournier, Florent Lheureux, Guillaume Louis, Saad Nseir, Gwenaelle Jacq, Cyril Goulenok, Grégoire Muller, Julio Badie, Bélaïd Bouhemad, Marjolaine Georges, Paul-Michel Mertes, Hamid Merdji, Vincent Castelain, Caroline Abdulmalak, Olivier Lesieur…

Individualization of PEEP and tidal volume in ARDS patients with electrical impedance tomography: a pilot feasibility study

In mechanically ventilated patients with acute respiratory distress syndrome (ARDS), electrical impedance tomography (EIT) provides information on alveolar cycling and overdistension as well as assessment of r...

Authors: Tobias Becher, Valerie Buchholz, Daniel Hassel, Timo Meinel, Dirk Schädler, Inéz Frerichs and Norbert Weiler

Target arterial PO₂ according to the underlying pathology: a mini-review of the available data in mechanically ventilated patients

There is an ongoing discussion whether hyperoxia, i.e. ventilation with high inspiratory O₂ concentrations (F_IO₂), and the consecutive hyperoxaemia, i.e. supraphysiological arterial O₂ tensions (PaO₂), have a pla...

Authors: Julien Demiselle, Enrico Calzia, Clair Hartmann, David Alexander Christian Messerer, Pierre Asfar, Peter Radermacher and Thomas Datzmann

Impact of dexamethasone on the incidence of ventilator-associated pneumonia and blood stream infections in COVID-19 patients requiring invasive mechanical ventilation: a multicenter retrospective study

Dexamethasone decreases mortality in patients with severe coronavirus disease 2019 (COVID-19) and has become the standard of care during the second wave of pandemic. Dexamethasone is an immunosuppressive treat...

Authors: Ines Gragueb-Chatti, Alexandre Lopez, Dany Hamidi, Christophe Guervilly, Anderson Loundou, Florence Daviet, Nadim Cassir, Laurent Papazian, Jean-Marie Forel, Marc Leone, Jean Dellamonica and Sami Hraiech

Acute kidney injury in SARS-CoV2-related pneumonia ICU patients: a retrospective multicenter study

While acute kidney injury (AKI) is frequent in severe SARS-CoV2-related pneumonia ICU patients, few data are still available about its risk factors.

Authors: Guillaume Geri, Michael Darmon, Lara Zafrani, Muriel Fartoukh, Guillaume Voiriot, Julien Le Marec, Saafa Nemlaghi, Antoine Vieillard-Baron and Elie Azoulay

Sleep alterations just after extubation do not predict short-term respiratory failure, but…

Authors: Dominique Robert

Correction to: Impact of systematic screening for AmpC-hyperproducing Enterobacterales intestinal carriage in intensive care unit patients

An amendment to this paper has been published and can be accessed via the original article.

Authors: Elsa Manquat, Matthieu Le Dorze, Gauthier Pean De Ponflly, Hanaa Benmansour, Rishma Amarsy, Emmanuelle Cambau, Benjamin Soyer, Benjamin Glenn Chousterman and Hervé Jacquier

Infectious events in patients with severe COVID-19: results of a cohort of patients with high prevalence of underlying immune defect

Empirical antibiotic has been considered in severe COVID-19 although little data are available regarding concomitant infections. This study aims to assess the frequency of infections, community and hospital-ac...

Authors: Anastasia Saade, Giulia Moratelli, Guillaume Dumas, Asma Mabrouki, Jean-Jacques Tudesq, Lara Zafrani, Elie Azoulay and Michael Darmon

Lipid and lipoprotein predictors of functional outcomes and long-term mortality after surgical sepsis

Sepsis is a life-threatening, dysregulated response to infection. Lipid biomarkers including cholesterol are dynamically regulated during sepsis and predict short-term outcomes. In this study, we investigated ...

Authors: Faheem W. Guirgis, Christiaan Leeuwenburgh, Lyle Moldawer, Gabriela Ghita, Lauren Page Black, Morgan Henson, Elizabeth DeVos, David Holden, Phil Efron, Srinivasa T. Reddy and Frederick A. Moore

Resuscitative endovascular balloon occlusion of the aorta vs epinephrine in the treatment of non-traumatic cardiac arrest in swine

The administration of epinephrine in the management of non-traumatic cardiac arrest remains recommended despite controversial effects on neurologic outcome. The use of resuscitative endovascular balloon occlus...

Authors: Alice Hutin, Yaël Levy, Fanny Lidouren, Matthias Kohlhauer, Pierre Carli, Bijan Ghaleh, Lionel Lamhaut and Renaud Tissier

The autonomic nervous system in septic shock and its role as a future therapeutic target: a narrative review

The autonomic nervous system (ANS) regulates the cardiovascular system. A growing body of experimental and clinical evidence confirms significant dysfunction of this regulation during sepsis and septic shock. ...

Authors: Marta Carrara, Manuela Ferrario, Bernardo Bollen Pinto and Antoine Herpain

Fluid-induced harm in the hospital: look beyond volume and start considering sodium. From physiology towards recommendations for daily practice in hospitalized adults

Iatrogenic fluid overload is a potential side effect of intravenous fluid therapy in the hospital. Little attention has been paid to sodium administration as a separate cause of harm. With this narrative revie...

Authors: Niels Van Regenmortel, Lynn Moers, Thomas Langer, Ella Roelant, Tim De Weerdt, Pietro Caironi, Manu L. N. G. Malbrain, Paul Elbers, Tim Van den Wyngaert and Philippe G. Jorens

Radiological pattern in ARDS patients: partitioned respiratory mechanics, gas exchange and lung recruitability

The ARDS is characterized by different degrees of impairment in oxygenation and distribution of the lung disease. Two radiological patterns have been described: a focal and a diffuse one. These two patterns co...

Authors: Silvia Coppola, Tommaso Pozzi, Martina Gurgitano, Alessandro Liguori, Ejona Duka, Francesca Bichi, Arianna Ciabattoni and Davide Chiumello

Characteristics, management, and prognosis of elderly patients with COVID-19 admitted in the ICU during the first wave: insights from the COVID-ICU study

The COVID-19 pandemic is a heavy burden in terms of health care resources. Future decision-making policies require consistent data on the management and prognosis of the older patients (> 70 years old) with CO...

Authors: Martin Dres, David Hajage, Said Lebbah, Antoine Kimmoun, Tai Pham, Gaëtan Béduneau, Alain Combes, Alain Mercat, Bertrand Guidet, Alexandre Demoule and Matthieu Schmidt

Simplified frontal EEG in adults under veno-arterial extracorporeal membrane oxygenation

EEG-based prognostication studies in intensive care units often rely on a standard 21-electrode montage (_stdEEG) requiring substantial human, technical, and financial resources. We here evaluate whether a simplif...

Authors: Cyril Touchard, Jérôme Cartailler, Geoffroy Vellieux, Etienne de Montmollin, Pierre Jaquet, Ruben Wanono, Jean Reuter, Marylou Para, Lila Bouadma, Jean-François Timsit, Marie-Pia d’Ortho, Nathalie Kubis, Anny Rouvel Tallec and Romain Sonneville

Specific exposure of ICU staff to SARS-CoV-2 seropositivity: a wide seroprevalence study in a French city-center hospital

Most hospital organizations have had to face the burden of managing the ongoing COVID-19 outbreak. One of the challenges in overcoming the influx of COVID-19 patients is controlling patient-to-staff transmissi...

Authors: Emmanuel Vivier, Caroline Pariset, Stephane Rio, Sophie Armand, Fanny Doroszewski, Delphine Richard, Marc Chardon, Georges Romero, Pierre Metral, Matthieu Pecquet and Adrien Didelot

Virtual reality vs. Kalinox® for management of pain in intensive care unit after cardiac surgery: a randomized study

The management of pain and anxiety remains a challenge in the intensive care unit. By distracting patients, virtual reality (VR) may have a role in painful procedures. We compared VR vs. an inhaled equimolar m...

Authors: Driss Laghlam, Cecile Naudin, Lucas Coroyer, Vincent Aidan, Julien Malvy, Ghilas Rahoual, Philippe Estagnasié and Pierre Squara

Convalescent plasma therapy and mortality in COVID-19 patients admitted to the ICU: a prospective observational study

This study aimed to quantify the potential survival benefit of convalescent plasma therapy (CVP) in critically ill patients with acute respiratory failure related to coronavirus disease-2019 (COVID-19).

Authors: Stefan Hatzl, Florian Posch, Nazanin Sareban, Martin Stradner, Konrad Rosskopf, Alexander C. Reisinger, Philipp Eller, Michael Schörghuber, Wolfgang Toller, Zdenka Sloup, Florian Prüller, Katharina Gütl, Stefan Pilz, Alexander R. Rosenkranz, Hildegard T. Greinix, Robert Krause…

Perceived inequity, professional and personal fulfillment by women intensivists in France

The medical workforce has been feminized for the last two decades worldwide. Nonetheless, women remain under-represented among intensivists. We conducted a survey among French women intensivists to assess thei...

Authors: Caroline Hauw-Berlemont, Cécile Aubron, Nadia Aissaoui, Laetitia Bodet-Contentin, Florence Boissier, Muriel Sarah Fartoukh, Mercedes Jourdain, Julien Le Marec, Julia Pestel, Charlotte Salmon Gandonnière, Fabienne Tamion and Olfa Hamzaoui

Role of sleep on respiratory failure after extubation in the ICU

Sleep had never been assessed immediately after extubation in patients still in the ICU. However, sleep deprivation may alter respiratory function and may promote respiratory failure. We hypothesized that slee...

Authors: Arnaud W. Thille, Stephanie Barrau, Clément Beuvon, Damien Marie, Faustine Reynaud, Justine Bardin, Adrien Pépin-Lehalleur, Vanessa Bironneau, Jean-Claude Meurice, Rémi Coudroy, Jean-Pierre Frat, René Robert, Christophe Rault and Xavier Drouot

Malignant pertussis in infants: factors associated with mortality in a multicenter cohort study

Malignant pertussis (MP) affects young infants and is characterized by respiratory distress, perpetual tachycardia and hyperleukocytosis up to 50 G/l, leading to multiple organ failure and death in 75% of case...

Authors: Mathilde Coquaz-Garoudet, Dominique Ploin, Robin Pouyau, Yoav Hoffmann, Julien-Frederic Baleine, Benoît Boeuf, Hugues Patural, Anne Millet, Marc Labenne, Renaud Vialet, Didier Pinquier, Marie Cotillon, Jérôme Rambaud and Etienne Javouhey

Transcranial sonographic assessment of the third ventricle in neuro-ICU patients to detect hydrocephalus: a diagnostic reliability pilot study

Transcranial sonography is a point-of-care tool recommended in intensive care units (ICU) to monitor brain injured patients. Objectives of the study was to assess feasibility and reliability of the third ventr...

Authors: Rémy Widehem, Paul Bory, Frédéric Greco, Frédérique Pavillard, Kévin Chalard, Alexandre Mas, Flora Djanikian, Julie Carr, Nicolas Molinari, Samir Jaber, Pierre-François Perrigault and Gerald Chanques

Response to the letter to the Editor “Regional citrate anticoagulation for intermittent hemodialysis in the intensive care. What is the optimal set-up?” by Gubensek et al.

Authors: Christophe Leroy and Alexandre Lautrette

Regional citrate anticoagulation for intermittent hemodialysis in the intensive care: what is the optimal setup?

Authors: Jakob Gubensek and Vanja Persic

Admission criteria and management of critical care patients in a pandemic context: position of the Ethics Commission of the French Intensive Care Society, update of April 2021

Intensive care unit professionals have experience in critical care and its proportionality, collegial decision-making, withholding or withdrawal of treatment deemed futile, and communication with patients’ rel...

Authors: Olivier Lesieur, Jean Pierre Quenot, Zoé Cohen-Solal, Raphaëlle David, Laure De Saint Blanquat, Maxime Elbaz, Bénédicte Gaillard Le Roux, Cyril Goulenok, Sylvain Lavoué, Virginie Lemiale, Emmanuelle Mercier, Chaouki Mezher, Benoît Misset, Gwendolyn Penven, Anne Laure Poujol, Bertrand Quentin…

Critical illness-related corticosteroid insufficiency during difficult weaning from mechanical ventilation

Critical illness-related corticosteroid insufficiency (CIRCI) is common during critical illness and is usually associated with poor outcomes, as prolonged duration of mechanical ventilation (MV) and higher mor...

Authors: François Bagate, Alexandre Bedet, Françoise Tomberli, Florence Boissier, Keyvan Razazi, Nicolas de Prost, Guillaume Carteaux and Armand Mekontso Dessap

Circadian rhythms in septic shock patients

Despite the intensive efforts to improve the diagnosis and therapy of sepsis over the last decade, the mortality of septic shock remains high and causes substantial socioeconomical burden of disease. The funct...

Authors: Gunnar Lachmann, Bharath Ananthasubramaniam, Viktor A. Wünsch, Lara-Marie Scherfig, Clarissa von Haefen, Cornelia Knaak, Andreas Edel, Lukas Ehlen, Barbara Koller, Anton Goldmann, Hanspeter Herzel, Achim Kramer and Claudia Spies

Sustained oxygenation improvement after first prone positioning is associated with liberation from mechanical ventilation and mortality in critically ill COVID-19 patients: a cohort study

Prone positioning (PP) has been used to improve oxygenation in patients affected by the SARS-CoV-2 disease (COVID-19). Several mechanisms, including lung recruitment and better lung ventilation/perfusion match...

Authors: Gaetano Scaramuzzo, Lorenzo Gamberini, Tommaso Tonetti, Gianluca Zani, Irene Ottaviani, Carlo Alberto Mazzoli, Chiara Capozzi, Emanuela Giampalma, Maria Letizia Bacchi Reggiani, Elisabetta Bertellini, Andrea Castelli, Irene Cavalli, Davide Colombo, Federico Crimaldi, Federica Damiani, Maurizio Fusari…

Low bicarbonate replacement fluid normalizes metabolic alkalosis during continuous veno-venous hemofiltration with regional citrate anticoagulation

Metabolic alkalosis is a frequently occurring problem during continuous veno-venous hemofiltration (CVVH) with regional citrate anticoagulation (RCA). This study aimed to evaluate the effectiveness of switchin...

Authors: Paul Köglberger, Sebastian J. Klein, Georg Franz Lehner, Romuald Bellmann, Andreas Peer, Daniel Schwärzler and Michael Joannidis

ABO blood types and sepsis mortality

We aimed to determine if the ABO blood types carry different risks of 30-day mortality, acute kidney injury (AKI), and endothelial damage in critically ill patients with sepsis. This was a retrospective cohort...

Authors: Theis S. Itenov, Daniel I. Sessler, Ashish K. Khanna, Sisse R. Ostrowski, Pär I. Johansson, Christian Erikstrup, Ole B. Pedersen, Sofie L. Rygård, Lars B. Holst, Morten H. Bestle, Lars Hein, Anne Lindhardt, Hami Tousi, Mads H. Andersen, Thomas Mohr, Jens D. Lundgren…

Outcome of acute kidney injury: how to make a difference?

Acute kidney injury (AKI) is one of the most frequent organ failure encountered among intensive care unit patients. In addition to the well-known immediate complications (hydroelectrolytic disorders, hypervole...

Authors: Matthieu Jamme, Matthieu Legrand and Guillaume Geri

Monitoring skin blood flow to rapidly identify alterations in tissue perfusion during fluid removal using continuous veno-venous hemofiltration in patients with circulatory shock

Continuous veno-venous hemofiltration (CVVH) can be used to reduce fluid overload and tissue edema, but excessive fluid removal may impair tissue perfusion. Skin blood flow (SBF) alters rapidly in shock, so it...

Authors: Wasineenart Mongkolpun, Péter Bakos, Jean-Louis Vincent and Jacques Creteur

Perioperative hemodynamic optimization: from guidelines to implementation—an experts’ opinion paper

Despite a large body of evidence, the implementation of guidelines on hemodynamic optimization and goal-directed therapy remains limited in daily routine practice. To facilitate/accelerate this implementation,...

Authors: Jean-Luc Fellahi, Emmanuel Futier, Camille Vaisse, Olivier Collange, Olivier Huet, Jerôme Loriau, Etienne Gayat, Benoit Tavernier, Matthieu Biais, Karim Asehnoune, Bernard Cholley and Dan Longrois

An international tool to measure perceived stressors in intensive care units: the PS-ICU scale

The intensive care unit is increasingly recognized as a stressful environment for healthcare professionals. This context has an impact on the health of these professionals but also on the quality of their pers...

Authors: Alexandra Laurent, Alicia Fournier, Florent Lheureux, Maria Cruz Martin Delgado, Maria G. Bocci, Alessia Prestifilippo, Pierre Aslanian, Julie Henriques, Sophie Paget-Bailly, Jean-Michel Constantin, Guillaume Besch, Jean-Pierre Quenot, Amelie Anota, Belaid Bouhemad and Gilles Capellier

Vascular access for renal replacement therapy among 459 critically ill patients: a pragmatic analysis of the randomized AKIKI trial

Vascular access for renal replacement therapy (RRT) is routine question in the intensive care unit. Randomized trials comparing jugular and femoral sites have shown similar rate of nosocomial events and cathet...

Authors: Nicolas Benichou, Saïd Lebbah, David Hajage, Laurent Martin-Lefèvre, Bertrand Pons, Eric Boulet, Alexandre Boyer, Guillaume Chevrel, Nicolas Lerolle, Dorothée Carpentier, Nicolas de Prost, Alexandre Lautrette, Anne Bretagnol, Julien Mayaux, Saad Nseir, Bruno Megarbane…

Effects of remote ischemic conditioning on microcirculatory alterations in patients with sepsis: a single-arm clinical trial

Remote ischemic conditioning (RIC) is a promising technique that may protect organs and tissues from the effects of additional ischemic episodes. However, the therapeutic efficacy of RIC in humans with sepsis ...

Authors: Inga Kiudulaite, Egle Belousoviene, Astra Vitkauskiene and Andrius Pranskunas

Inter-hospital transport of critically ill patients to manage the intensive care unit surge during the COVID-19 pandemic in France

The COVID-19 pandemic led authorities to evacuate via various travel modalities critically ill ventilated patients into less crowded units. However, it is not known if interhospital transport impacts COVID-19 ...

Authors: Benoit Painvin, Hélène Messet, Maeva Rodriguez, Thomas Lebouvier, Delphine Chatellier, Louis Soulat, Stephane Ehrmann, Arnaud W. Thille, Arnaud Gacouin and Jean-Marc Tadie

Efficacy and safety of human soluble thrombomodulin (ART-123) for treatment of patients in France with sepsis-associated coagulopathy: post hoc analysis of SCARLET

The phase 3 multinational SCARLET study evaluated the efficacy and safety of a recombinant human soluble thrombomodulin (ART-123) for treatment of sepsis-associated coagulopathy (SAC), which correlates with in...

Authors: Bruno François, Maud Fiancette, Julie Helms, Emmanuelle Mercier, Jean-Baptiste Lascarrou, Toshihiko Kayanoki, Kosuke Tanaka, David Fineberg, Jean-Louis Vincent and Xavier Wittebole

Left ventricular longitudinal wall fractional shortening accurately predicts longitudinal strain in critically ill patients with septic shock

Left ventricular longitudinal strain (LVLS) may be a sensitive indicator of left ventricular (LV) systolic function in patients with sepsis, but is dependent on high image quality and analysis software. Mitral...

Authors: Patrik Johansson Blixt, Michelle S. Chew, Rasmus Åhman, Lina de Geer, Lill Blomqwist, Meriam Åström Aneq, Jan Engvall and Henrik Andersson

Clinical performance of lung ultrasound in predicting ARDS morphology

To assess diagnostic performance of lung ultrasound (LUS) in identifying ARDS morphology (focal vs non-focal), compared with the gold standard computed tomography.

Authors: Andrea Costamagna, Emanuele Pivetta, Alberto Goffi, Irene Steinberg, Pietro Arina, Anna Teresa Mazzeo, Lorenzo Del Sorbo, Simona Veglia, Ottavio Davini, Luca Brazzi, V. Marco Ranieri and Vito Fanelli

Soluble receptor for advanced glycation end products (sRAGE) as a biomarker of COVID-19 disease severity and indicator of the need for mechanical ventilation, ARDS and mortality

COVID-19 pneumonia and subsequent respiratory failure is causing an immense strain on intensive care units globally. Early prediction of severe disease enables clinicians to avoid acute respiratory distress sy...

Authors: Adeline Lim, Aleksandar Radujkovic, Markus A. Weigand and Uta Merle

An international survey on aminoglycoside practices in critically ill patients: the AMINO III study

While aminoglycosides (AG) have been used for decades, debate remains on their optimal dosing strategy. We investigated the international practices of AG usage specifically regarding dosing and therapeutic dru...

Authors: Claire Roger, Benjamin Louart, Loubna Elotmani, Greg Barton, Leslie Escobar, Despoina Koulenti, Jeffrey Lipman, Marc Leone, Laurent Muller, Caroline Boutin, Julien Amour, Iouri Banakh, Joel Cousson, Jeremy Bourenne, Jean-Michel Constantin, Jacques Albanese…

Pain and dyspnea control during awake fiberoptic bronchoscopy in critically ill patients: safety and efficacy of remifentanil target-controlled infusion

Flexible fiberoptic bronchoscopy is frequently used in intensive care unit, but is a source of discomfort, dyspnea and anxiety for patients. Our objective was to assess the feasibility and tolerance of a sedat...

Authors: Margot Caron, Antoine Parrot, Alexandre Elabbadi, Sophie Dupeyrat, Matthieu Turpin, Thomas Baury, Sacha Rozencwajg, Clarisse Blayau, Jean-Pierre Fulgencio, Aude Gibelin, Pierre-Yves Blanchard, Séverine Rodriguez, Daisy Daigné, Marie-Cécile Allain, Muriel Fartoukh and Tài Pham

Cerebrovascular autoregulation and arterial carbon dioxide in patients with acute respiratory distress syndrome: a prospective observational cohort study

Early hypercapnia is common in patients with acute respiratory distress syndrome (ARDS) and is associated with increased mortality. Fluctuations of carbon dioxide have been associated with adverse neurological...

Authors: Ursula Kahl, Yuanyuan Yu, Axel Nierhaus, Daniel Frings, Barbara Sensen, Anne Daubmann, Stefan Kluge and Marlene Fischer

Reply to: High levels of plasma biomarkers at 24 h were found to be strong predictors of 90-day mortality: beware of some potential confounders!

Authors: Toni Jäntti, Veli-Pekka Harjola, Mikko Haapio and Johan Lassus