Articles

Role of sleep on respiratory failure after extubation in the ICU

Sleep had never been assessed immediately after extubation in patients still in the ICU. However, sleep deprivation may alter respiratory function and may promote respiratory failure. We hypothesized that slee...

Authors: Arnaud W. Thille, Stephanie Barrau, Clément Beuvon, Damien Marie, Faustine Reynaud, Justine Bardin, Adrien Pépin-Lehalleur, Vanessa Bironneau, Jean-Claude Meurice, Rémi Coudroy, Jean-Pierre Frat, René Robert, Christophe Rault and Xavier Drouot

Malignant pertussis in infants: factors associated with mortality in a multicenter cohort study

Malignant pertussis (MP) affects young infants and is characterized by respiratory distress, perpetual tachycardia and hyperleukocytosis up to 50 G/l, leading to multiple organ failure and death in 75% of case...

Authors: Mathilde Coquaz-Garoudet, Dominique Ploin, Robin Pouyau, Yoav Hoffmann, Julien-Frederic Baleine, Benoît Boeuf, Hugues Patural, Anne Millet, Marc Labenne, Renaud Vialet, Didier Pinquier, Marie Cotillon, Jérôme Rambaud and Etienne Javouhey

Transcranial sonographic assessment of the third ventricle in neuro-ICU patients to detect hydrocephalus: a diagnostic reliability pilot study

Transcranial sonography is a point-of-care tool recommended in intensive care units (ICU) to monitor brain injured patients. Objectives of the study was to assess feasibility and reliability of the third ventr...

Authors: Rémy Widehem, Paul Bory, Frédéric Greco, Frédérique Pavillard, Kévin Chalard, Alexandre Mas, Flora Djanikian, Julie Carr, Nicolas Molinari, Samir Jaber, Pierre-François Perrigault and Gerald Chanques

Response to the letter to the Editor “Regional citrate anticoagulation for intermittent hemodialysis in the intensive care. What is the optimal set-up?” by Gubensek et al.

Authors: Christophe Leroy and Alexandre Lautrette

Regional citrate anticoagulation for intermittent hemodialysis in the intensive care: what is the optimal setup?

Authors: Jakob Gubensek and Vanja Persic

Admission criteria and management of critical care patients in a pandemic context: position of the Ethics Commission of the French Intensive Care Society, update of April 2021

Intensive care unit professionals have experience in critical care and its proportionality, collegial decision-making, withholding or withdrawal of treatment deemed futile, and communication with patients’ rel...

Authors: Olivier Lesieur, Jean Pierre Quenot, Zoé Cohen-Solal, Raphaëlle David, Laure De Saint Blanquat, Maxime Elbaz, Bénédicte Gaillard Le Roux, Cyril Goulenok, Sylvain Lavoué, Virginie Lemiale, Emmanuelle Mercier, Chaouki Mezher, Benoît Misset, Gwendolyn Penven, Anne Laure Poujol, Bertrand Quentin…

Critical illness-related corticosteroid insufficiency during difficult weaning from mechanical ventilation

Critical illness-related corticosteroid insufficiency (CIRCI) is common during critical illness and is usually associated with poor outcomes, as prolonged duration of mechanical ventilation (MV) and higher mor...

Authors: François Bagate, Alexandre Bedet, Françoise Tomberli, Florence Boissier, Keyvan Razazi, Nicolas de Prost, Guillaume Carteaux and Armand Mekontso Dessap

Circadian rhythms in septic shock patients

Despite the intensive efforts to improve the diagnosis and therapy of sepsis over the last decade, the mortality of septic shock remains high and causes substantial socioeconomical burden of disease. The funct...

Authors: Gunnar Lachmann, Bharath Ananthasubramaniam, Viktor A. Wünsch, Lara-Marie Scherfig, Clarissa von Haefen, Cornelia Knaak, Andreas Edel, Lukas Ehlen, Barbara Koller, Anton Goldmann, Hanspeter Herzel, Achim Kramer and Claudia Spies

Sustained oxygenation improvement after first prone positioning is associated with liberation from mechanical ventilation and mortality in critically ill COVID-19 patients: a cohort study

Prone positioning (PP) has been used to improve oxygenation in patients affected by the SARS-CoV-2 disease (COVID-19). Several mechanisms, including lung recruitment and better lung ventilation/perfusion match...

Authors: Gaetano Scaramuzzo, Lorenzo Gamberini, Tommaso Tonetti, Gianluca Zani, Irene Ottaviani, Carlo Alberto Mazzoli, Chiara Capozzi, Emanuela Giampalma, Maria Letizia Bacchi Reggiani, Elisabetta Bertellini, Andrea Castelli, Irene Cavalli, Davide Colombo, Federico Crimaldi, Federica Damiani, Maurizio Fusari…

Low bicarbonate replacement fluid normalizes metabolic alkalosis during continuous veno-venous hemofiltration with regional citrate anticoagulation

Metabolic alkalosis is a frequently occurring problem during continuous veno-venous hemofiltration (CVVH) with regional citrate anticoagulation (RCA). This study aimed to evaluate the effectiveness of switchin...

Authors: Paul Köglberger, Sebastian J. Klein, Georg Franz Lehner, Romuald Bellmann, Andreas Peer, Daniel Schwärzler and Michael Joannidis

ABO blood types and sepsis mortality

We aimed to determine if the ABO blood types carry different risks of 30-day mortality, acute kidney injury (AKI), and endothelial damage in critically ill patients with sepsis. This was a retrospective cohort...

Authors: Theis S. Itenov, Daniel I. Sessler, Ashish K. Khanna, Sisse R. Ostrowski, Pär I. Johansson, Christian Erikstrup, Ole B. Pedersen, Sofie L. Rygård, Lars B. Holst, Morten H. Bestle, Lars Hein, Anne Lindhardt, Hami Tousi, Mads H. Andersen, Thomas Mohr, Jens D. Lundgren…

Outcome of acute kidney injury: how to make a difference?

Acute kidney injury (AKI) is one of the most frequent organ failure encountered among intensive care unit patients. In addition to the well-known immediate complications (hydroelectrolytic disorders, hypervole...

Authors: Matthieu Jamme, Matthieu Legrand and Guillaume Geri

Monitoring skin blood flow to rapidly identify alterations in tissue perfusion during fluid removal using continuous veno-venous hemofiltration in patients with circulatory shock

Continuous veno-venous hemofiltration (CVVH) can be used to reduce fluid overload and tissue edema, but excessive fluid removal may impair tissue perfusion. Skin blood flow (SBF) alters rapidly in shock, so it...

Authors: Wasineenart Mongkolpun, Péter Bakos, Jean-Louis Vincent and Jacques Creteur

Perioperative hemodynamic optimization: from guidelines to implementation—an experts’ opinion paper

Despite a large body of evidence, the implementation of guidelines on hemodynamic optimization and goal-directed therapy remains limited in daily routine practice. To facilitate/accelerate this implementation,...

Authors: Jean-Luc Fellahi, Emmanuel Futier, Camille Vaisse, Olivier Collange, Olivier Huet, Jerôme Loriau, Etienne Gayat, Benoit Tavernier, Matthieu Biais, Karim Asehnoune, Bernard Cholley and Dan Longrois

An international tool to measure perceived stressors in intensive care units: the PS-ICU scale

The intensive care unit is increasingly recognized as a stressful environment for healthcare professionals. This context has an impact on the health of these professionals but also on the quality of their pers...

Authors: Alexandra Laurent, Alicia Fournier, Florent Lheureux, Maria Cruz Martin Delgado, Maria G. Bocci, Alessia Prestifilippo, Pierre Aslanian, Julie Henriques, Sophie Paget-Bailly, Jean-Michel Constantin, Guillaume Besch, Jean-Pierre Quenot, Amelie Anota, Belaid Bouhemad and Gilles Capellier

Vascular access for renal replacement therapy among 459 critically ill patients: a pragmatic analysis of the randomized AKIKI trial

Vascular access for renal replacement therapy (RRT) is routine question in the intensive care unit. Randomized trials comparing jugular and femoral sites have shown similar rate of nosocomial events and cathet...

Authors: Nicolas Benichou, Saïd Lebbah, David Hajage, Laurent Martin-Lefèvre, Bertrand Pons, Eric Boulet, Alexandre Boyer, Guillaume Chevrel, Nicolas Lerolle, Dorothée Carpentier, Nicolas de Prost, Alexandre Lautrette, Anne Bretagnol, Julien Mayaux, Saad Nseir, Bruno Megarbane…

Effects of remote ischemic conditioning on microcirculatory alterations in patients with sepsis: a single-arm clinical trial

Remote ischemic conditioning (RIC) is a promising technique that may protect organs and tissues from the effects of additional ischemic episodes. However, the therapeutic efficacy of RIC in humans with sepsis ...

Authors: Inga Kiudulaite, Egle Belousoviene, Astra Vitkauskiene and Andrius Pranskunas

Inter-hospital transport of critically ill patients to manage the intensive care unit surge during the COVID-19 pandemic in France

The COVID-19 pandemic led authorities to evacuate via various travel modalities critically ill ventilated patients into less crowded units. However, it is not known if interhospital transport impacts COVID-19 ...

Authors: Benoit Painvin, Hélène Messet, Maeva Rodriguez, Thomas Lebouvier, Delphine Chatellier, Louis Soulat, Stephane Ehrmann, Arnaud W. Thille, Arnaud Gacouin and Jean-Marc Tadie

Efficacy and safety of human soluble thrombomodulin (ART-123) for treatment of patients in France with sepsis-associated coagulopathy: post hoc analysis of SCARLET

The phase 3 multinational SCARLET study evaluated the efficacy and safety of a recombinant human soluble thrombomodulin (ART-123) for treatment of sepsis-associated coagulopathy (SAC), which correlates with in...

Authors: Bruno François, Maud Fiancette, Julie Helms, Emmanuelle Mercier, Jean-Baptiste Lascarrou, Toshihiko Kayanoki, Kosuke Tanaka, David Fineberg, Jean-Louis Vincent and Xavier Wittebole

Left ventricular longitudinal wall fractional shortening accurately predicts longitudinal strain in critically ill patients with septic shock

Left ventricular longitudinal strain (LVLS) may be a sensitive indicator of left ventricular (LV) systolic function in patients with sepsis, but is dependent on high image quality and analysis software. Mitral...

Authors: Patrik Johansson Blixt, Michelle S. Chew, Rasmus Åhman, Lina de Geer, Lill Blomqwist, Meriam Åström Aneq, Jan Engvall and Henrik Andersson

Clinical performance of lung ultrasound in predicting ARDS morphology

To assess diagnostic performance of lung ultrasound (LUS) in identifying ARDS morphology (focal vs non-focal), compared with the gold standard computed tomography.

Authors: Andrea Costamagna, Emanuele Pivetta, Alberto Goffi, Irene Steinberg, Pietro Arina, Anna Teresa Mazzeo, Lorenzo Del Sorbo, Simona Veglia, Ottavio Davini, Luca Brazzi, V. Marco Ranieri and Vito Fanelli

Soluble receptor for advanced glycation end products (sRAGE) as a biomarker of COVID-19 disease severity and indicator of the need for mechanical ventilation, ARDS and mortality

COVID-19 pneumonia and subsequent respiratory failure is causing an immense strain on intensive care units globally. Early prediction of severe disease enables clinicians to avoid acute respiratory distress sy...

Authors: Adeline Lim, Aleksandar Radujkovic, Markus A. Weigand and Uta Merle

An international survey on aminoglycoside practices in critically ill patients: the AMINO III study

While aminoglycosides (AG) have been used for decades, debate remains on their optimal dosing strategy. We investigated the international practices of AG usage specifically regarding dosing and therapeutic dru...

Authors: Claire Roger, Benjamin Louart, Loubna Elotmani, Greg Barton, Leslie Escobar, Despoina Koulenti, Jeffrey Lipman, Marc Leone, Laurent Muller, Caroline Boutin, Julien Amour, Iouri Banakh, Joel Cousson, Jeremy Bourenne, Jean-Michel Constantin, Jacques Albanese…

Pain and dyspnea control during awake fiberoptic bronchoscopy in critically ill patients: safety and efficacy of remifentanil target-controlled infusion

Flexible fiberoptic bronchoscopy is frequently used in intensive care unit, but is a source of discomfort, dyspnea and anxiety for patients. Our objective was to assess the feasibility and tolerance of a sedat...

Authors: Margot Caron, Antoine Parrot, Alexandre Elabbadi, Sophie Dupeyrat, Matthieu Turpin, Thomas Baury, Sacha Rozencwajg, Clarisse Blayau, Jean-Pierre Fulgencio, Aude Gibelin, Pierre-Yves Blanchard, Séverine Rodriguez, Daisy Daigné, Marie-Cécile Allain, Muriel Fartoukh and Tài Pham

Cerebrovascular autoregulation and arterial carbon dioxide in patients with acute respiratory distress syndrome: a prospective observational cohort study

Early hypercapnia is common in patients with acute respiratory distress syndrome (ARDS) and is associated with increased mortality. Fluctuations of carbon dioxide have been associated with adverse neurological...

Authors: Ursula Kahl, Yuanyuan Yu, Axel Nierhaus, Daniel Frings, Barbara Sensen, Anne Daubmann, Stefan Kluge and Marlene Fischer

Reply to: High levels of plasma biomarkers at 24 h were found to be strong predictors of 90-day mortality: beware of some potential confounders!

Authors: Toni Jäntti, Veli-Pekka Harjola, Mikko Haapio and Johan Lassus

High levels of plasma biomarkers at 24 h were found to be strong predictors of 90-day mortality: beware of some potential confounders!

Authors: Patrick M. Honore, Sebastien Redant, Thierry Preseau, Keitiane Kaefer, Leonel Barreto Gutierrez, Rachid Attou, Andrea Gallerani and David De Bels

Severe liver dysfunction complicating course of COVID-19 in the critically ill: multifactorial cause or direct viral effect?

SARS-CoV-2 caused a pandemic and global threat for human health. Presence of liver injury was commonly reported in patients with coronavirus disease 2019 (COVID-19). However, reports on severe liver dysfunctio...

Authors: Kevin Roedl, Dominik Jarczak, Andreas Drolz, Dominic Wichmann, Olaf Boenisch, Geraldine de Heer, Christoph Burdelski, Daniel Frings, Barbara Sensen, Axel Nierhaus, Marc Lütgehetmann, Stefan Kluge and Valentin Fuhrmann

The use of extracorporeal CO₂ removal in acute respiratory failure

Chronic obstructive pulmonary disease (COPD) exacerbation and protective mechanical ventilation of acute respiratory distress syndrome (ARDS) patients induce hypercapnic respiratory acidosis.

Authors: Raphaël Giraud, Carlo Banfi, Benjamin Assouline, Amandine De Charrière, Maurizio Cecconi and Karim Bendjelid

Early combination of albumin with crystalloids administration might be beneficial for the survival of septic patients: a retrospective analysis from MIMIC-IV database

Fluid therapy is a cornerstone in the treatment of sepsis. Recently, the guidelines have recommended the combined administration that using crystalloids plus albumin for septic patients, but the optimal timing fo...

Authors: Shiyu Zhou, Zhenhua Zeng, Hongxia Wei, Tong Sha and Shengli An

New clinical algorithm including fungal biomarkers to better diagnose probable invasive pulmonary aspergillosis in ICU

The classification of invasive pulmonary aspergillosis (IPA) issued by the European Organization for the Research and Treatment of Cancer/Mycoses Study Group Education and Research Consortium (EORTC/MSGERC) is...

Authors: Joffrey Hamam, Jean-Christophe Navellou, Anne-Pauline Bellanger, Stéphane Bretagne, Hadrien Winiszewski, Emeline Scherer, Gael Piton and Laurence Millon

Serum melatonin concentration in critically ill patients randomized to sedation or non-sedation

Abolished circadian rhythm is associated with altered cognitive function, delirium, and as a result increased mortality in critically ill patients, especially in those who are mechanically ventilated. The caus...

Authors: Jakob Oxlund, Torben Knudsen, Thomas Strøm, Jørgen T. Lauridsen, Poul J. Jennum and Palle Toft

Ability of procalcitonin to distinguish between bacterial and nonbacterial infection in severe acute exacerbation of chronic obstructive pulmonary syndrome in the ICU

To assess the ability of procalcitonin (PCT) to distinguish between bacterial and nonbacterial causes of patients with severe acute exacerbation of COPD (AECOPD) admitted to the ICU, we conducted a retrospecti...

Authors: Cédric Daubin, François Fournel, Fabrice Thiollière, Fabrice Daviaud, Michel Ramakers, Andréa Polito, Bernard Flocard, Xavier Valette, Damien Du Cheyron, Nicolas Terzi, Muriel Fartoukh, Stephane Allouche and Jean-Jacques Parienti

Continuous positive airway pressure for respiratory support during COVID-19 pandemic: a frugal approach from bench to bedside

We describe a frugal approach (focusing on needs, performance, and costs) to manage a massive influx of COVID-19 patients with acute hypoxemic respiratory failure (AHRF) using the Boussignac valve protected by...

Authors: Guillaume Carteaux, Manuella Pons, François Morin, Samuel Tuffet, Arnaud Lesimple, Bilal Badat, Anne-Fleur Haudebourg, François Perier, Yvon Deplante, Constance Guillaud, Frédéric Schlemmer, Elena Fois, Nicolas Mongardon, Mehdi Khellaf, Karim Jaffal, Camille Deguillard…

High flow nasal oxygen therapy to avoid invasive mechanical ventilation in SARS-CoV-2 pneumonia: a retrospective study

The efficacy of high flow nasal canula oxygen therapy (HFNO) to prevent invasive mechanical ventilation (IMV) is not well established in severe coronavirus disease 2019 (COVID-19). The aim of this study was to...

Authors: Nicolas Bonnet, Olivier Martin, Marouane Boubaya, Vincent Levy, Nathan Ebstein, Philippe Karoubi, Yacine Tandjaoui-Lambiotte, Guillaume Van Der Meersch, Johanna Oziel, Marie Soulie, Mohamed Ghalayini, Anais Winchenne, Jean Ralph Zahar, Passem Ahmed, Stéphane Gaudry and Yves Cohen

Intensive care management of patients with COVID-19: a practical approach

SARS-CoV-2, the causative agent of coronavirus disease 2019 (COVID-19), is responsible for the largest pandemic facing humanity since the Spanish flu pandemic in the early twentieth century. Since there is no ...

Authors: Ludhmila Abrahão Hajjar, Isabela Bispo Santos da Silva Costa, Stephanie Itala Rizk, Bruno Biselli, Brenno Rizerio Gomes, Cristina Salvadori Bittar, Gisele Queiroz de Oliveira, Juliano Pinheiro de Almeida, Mariana Vieira de Oliveira Bello, Cibele Garzillo, Alcino Costa Leme, Moizo Elena, Fernando Val, Marcela de Almeida Lopes, Marcus Vinícius Guimarães Lacerda, José Antonio Franchini Ramires…

Determinants of hospital and one-year mortality among older patients admitted to intensive care units: results from the multicentric SENIOREA cohort

Improving outcomes of older patients admitted into intensive care units (ICU) is a raising concern. This study aimed at determining which geriatric and ICU parameters were associated with in-hospital and long-...

Authors: Julien Demiselle, Guillaume Duval, Jean-François Hamel, Anne Renault, Laetitia Bodet-Contentin, Laurent Martin-Lefèvre, Dominique Vivier, Daniel Villers, Montaine Lefèvre, René Robert, Philippe Markowicz, Sylvain Lavoué, Anne Courte, Eddy Lebas, Stéphanie Chevalier, Cédric Annweiler…

Predicting fluid responsiveness in non-intubated COVID-19 patients: two methods are better than one

Authors: Morgan Caplan, Michael Howsam, Raphael Favory and Sebastien Preau

Preemptive ganciclovir for mechanically ventilated patients with cytomegalovirus reactivation

The effect of cytomegalovirus (CMV) reactivation on the length of mechanical ventilation and mortality in immunocompetent ICU patients requiring invasive mechanical ventilation remains controversial. The main ...

Authors: Laurent Papazian, Samir Jaber, Sami Hraiech, Karine Baumstarck, Sophie Cayot-Constantin, Nadia Aissaoui, Boris Jung, Marc Leone, Bertrand Souweine, Carole Schwebel, Jérémy Bourenne, Jérôme Allardet-Servent, Toufik Kamel, Qin Lu, Christine Zandotti, Anderson Loundou…

Validation of the pediatric refractory septic shock definition: post hoc analysis of a controlled trial

The European Society of Pediatric and Neonatal Intensive Care (ESPNIC) developed and validated a definition of pediatric refractory septic shock (RSS), based on two septic shock scores (SSS). Both bedside SSS ...

Authors: Luc Morin, Karthik Narayanan Ramaswamy, Muralidharan Jayashree, Arun Bansal, Karthi Nallasamy, Pierre Tissieres and Sunit Singhi

Poor outcome associated with mucormycosis in critically ill hematological patients: results of a multicenter study

Mucormycosis is an emerging fungal infection that may lead to multi-organ failure, especially in patients with hematological malignancies (HM). We performed a retrospective, cohort study, in five intensive car...

Authors: Matthieu Jestin, Elie Azoulay, Frédéric Pène, Fabrice Bruneel, Julien Mayaux, Martin Murgier, Michael Darmon and Sandrine Valade

Non-invasive ventilation alternating with high-flow nasal oxygen versus high-flow nasal oxygen alone after extubation in COPD patients: a post hoc analysis of a randomized controlled trial

Several randomized clinical trials have shown that non-invasive ventilation (NIV) applied immediately after extubation may prevent reintubation in patients at high-risk of extubation failure. However, most of ...

Authors: Arnaud W. Thille, Rémi Coudroy, Mai-Anh Nay, Arnaud Gacouin, Maxens Decavèle, Romain Sonneville, François Beloncle, Christophe Girault, Laurence Dangers, Alexandre Lautrette, Quentin Levrat, Anahita Rouzé, Emmanuel Vivier, Jean-Baptiste Lascarrou, Jean-Damien Ricard, Keyvan Razazi…

Outcomes of severe systemic rheumatic disease patients requiring extracorporeal membrane oxygenation

Systemic rheumatic diseases (SRDs) are a group of inflammatory disorders that can require intensive care unit (ICU) admission because of multiorgan involvement with end-organ failure(s). Critically ill SRD pat...

Authors: Pierre Bay, Guillaume Lebreton, Alexis Mathian, Pierre Demondion, Cyrielle Desnos, Juliette Chommeloux, Guillaume Hékimian, Nicolas Bréchot, Ania Nieszkowska, Matthieu Schmidt, Fleur Cohen-Aubart, Pascal Leprince, Charles-Edouard Luyt, Zahir Amoura, Alain Combes and Marc Pineton de Chambrun

Predictors of fluid responsiveness in critically ill patients mechanically ventilated at low tidal volumes: systematic review and meta-analysis

Dynamic predictors of fluid responsiveness have shown good performance in mechanically ventilated patients at tidal volumes (Vt) > 8 mL kg⁻¹. Nevertheless, most critically ill conditions demand lower Vt. We sough...

Authors: Jorge Iván Alvarado Sánchez, Juan Daniel Caicedo Ruiz, Juan José Diaztagle Fernández, William Fernando Amaya Zuñiga, Gustavo Adolfo Ospina-Tascón and Luis Eduardo Cruz Martínez

Levosimendan use in patients with acute heart failure and reduced ejection fraction with or without severe renal dysfunction in critical cardiac care units: a multi-institution database study

Acute heart failure is a life-threatening clinical condition. Levosimendan is an effective inotropic agent used to maintain cardiac output, but its usage is limited by the lack of evidence in patients with sev...

Authors: Cze-Ci Chan, Kuang-Tso Lee, Wan-Jing Ho, Yi-Hsin Chan and Pao-Hsien Chu

Non-invasive method to detect high respiratory effort and transpulmonary driving pressures in COVID-19 patients during mechanical ventilation

High respiratory drive in mechanically ventilated patients with spontaneous breathing effort may cause excessive lung stress and strain and muscle loading. Therefore, it is important to have a reliable estimat...

Authors: Lisanne Roesthuis, Maarten van den Berg and Hans van der Hoeven

Predictive value of plasma proenkephalin and neutrophil gelatinase-associated lipocalin in acute kidney injury and mortality in cardiogenic shock

Acute kidney injury (AKI) is a frequent form of organ injury in cardiogenic shock. However, data on AKI markers such as plasma proenkephalin (P-PENK) and neutrophil gelatinase-associated lipocalin (P-NGAL) in ...

Authors: Toni Jäntti, Tuukka Tarvasmäki, Veli-Pekka Harjola, Kari Pulkki, Heidi Turkia, Tuija Sabell, Heli Tolppanen, Raija Jurkko, Mari Hongisto, Anu Kataja, Alessandro Sionis, Jose Silva-Cardoso, Marek Banaszewski, Salvatore DiSomma, Alexandre Mebazaa, Mikko Haapio…

Sympathetic stimulation increases serum lactate concentrations in patients admitted with sepsis: implications for resuscitation strategies

Diametrically opposed positions exist regarding the deleterious effects of elevated lactate. There are data suggesting that it is a detrimental proxy for tissue hypoperfusion and anaerobic metabolism in sepsis...

Authors: Nikhil Jagan, Lee E. Morrow, Ryan W. Walters, Robert W. Plambeck, Tej M. Patel, Douglas R. Moore and Mark A. Malesker

Integrity at end of life in the intensive care unit: a qualitative study of nurses’ views

Integrity is a core value for delivering ethical health care. However, there is a lack of precision in defining what integrity is and how nurses understand it. In the setting of nurses caring for critically il...

Authors: Lena Palmryd, Åsa Rejnö and Tove E. Godskesen

Reliability of the Clinical Frailty Scale in very elderly ICU patients: a prospective European study

Frailty is a valuable predictor for outcome in elderly ICU patients, and has been suggested to be used in various decision-making processes prior to and during an ICU admission. There are many instruments deve...

Authors: Hans Flaatten, Bertrand Guidet, Finn H. Andersen, Antonio Artigas, Maurizio Cecconi, Ariane Boumendil, Muhammed Elhadi, Jesper Fjølner, Michael Joannidis, Christian Jung, Susannah Leaver, Brian Marsh, Rui Moreno, Sandra Oeyen, Yuriy Nalapko, Joerg C. Schefold…