Articles

Mortality and morbidity of low-grade red blood cell transfusions in septic patients: a propensity score-matched observational study of a liberal transfusion strategy

Red blood cell (RBC) transfusions are associated with risks including immunological reactions and volume overload. Current guidelines suggest a restrictive transfusion strategy in most patients with sepsis but...

Authors: Caroline Ulfsdotter Nilsson, Peter Bentzer, Linnéa E. Andersson, Sofia A. Björkman, Fredrik P. Hanssson and Thomas Kander

Symptoms of burnout in intensive care unit specialists facing the COVID-19 outbreak

The COVID-19 pandemic has resulted in an unprecedented healthcare crisis with a high prevalence of psychological distress in healthcare providers. We sought to document the prevalence of burnout syndrome among...

Authors: Elie Azoulay, Jan De Waele, Ricard Ferrer, Thomas Staudinger, Marta Borkowska, Pedro Povoa, Katerina Iliopoulou, Antonio Artigas, Stefan J. Schaller, Manu Shankar Hari, Mariangela Pellegrini, Michael Darmon, Jozef Kesecioglu and Maurizio Cecconi

Diastolic shock index (DSI) works… and it could be a quite useful tool

Authors: Gustavo A. Ospina-Tascón, Glenn Hernández and Jan Bakker

Is hypoxemia explained by intracardiac or intrapulmonary shunt in COVID-19-related acute respiratory distress syndrome?

Hypoxemia is the main feature of COVID-19-related acute respiratory distress syndrome (C-ARDS), but its underlying mechanisms are debated, especially in patients with low respiratory system elastance (Ers). We...

Authors: Paul Masi, François Bagate, Thomas d’Humières, Lara Al-Assaad, Laure Abou Chakra, Genevieve Derumeaux and Armand Mekontso Dessap

Progression of regional lung strain and heterogeneity in lung injury: assessing the evolution under spontaneous breathing and mechanical ventilation

Protective mechanical ventilation (MV) aims at limiting global lung deformation and has been associated with better clinical outcomes in acute respiratory distress syndrome (ARDS) patients. In ARDS lungs witho...

Authors: Daniel E. Hurtado, Benjamín Erranz, Felipe Lillo, Mauricio Sarabia-Vallejos, Pablo Iturrieta, Felipe Morales, Katherine Blaha, Tania Medina, Franco Diaz and Pablo Cruces

Pharmacokinetics of tigecycline in critically ill patients with liver failure defined by maximal liver function capacity test (LiMAx)

In critically ill patients, tigecycline (TGC) remains an important therapeutic option due to its efficacy against multiresistant Gram-positive and Gram-negative bacteria. TGC is metabolized and eliminated pred...

Authors: Rawan Alraish, Sebastian G. Wicha, Otto R. Frey, Anka C. Roehr, Johann Pratschke, Martin Stockmann, Tilo Wuensch and Magnus Kaffarnik

P-SILI is not justification for intubation of COVID-19 patients

Authors: Martin J. Tobin, Franco Laghi and Amal Jubran

Cognitive and psychosocial outcomes of mechanically ventilated intensive care patients with and without delirium

Delirium is common in intensive care patients and is associated with short- and long-term adverse outcomes. We investigated the long-term risk of cognitive impairment and post-traumatic stress disorder (PTSD) ...

Authors: Daniella Bulic, Michael Bennett, Ekavi N. Georgousopoulou, Yahya Shehabi, Tai Pham, Jeffrey C. L. Looi and Frank M. P. van Haren

The diastolic shock index works… but, what is it?

Authors: Rafael Dalmau

Electrical impedance tomography: the solution for lung morphology assessment?

Authors: Florian Blanchard, Adrien Picod and Jean-Michel Constantin

Accuracy of the clinical pulmonary infection score to differentiate ventilator-associated tracheobronchitis from ventilator-associated pneumonia

Differentiating Ventilator-Associated Tracheobronchitis (VAT) from Ventilator-Associated Pneumonia (VAP) may be challenging for clinicians, yet their management currently differs. In this study, we evaluated t...

Authors: Alexandre Gaudet, Ignacio Martin-Loeches, Pedro Povoa, Alejandro Rodriguez, Jorge Salluh, Alain Duhamel and Saad Nseir

Assessing transpulmonary pressure via direct pleural manometry

Authors: Christopher Rugg, Stefan Schmid, Janett Kreutziger and Mathias Ströhle

Clinical outcomes of COVID-19 in Wuhan, China: a large cohort study

Since December 2019, an outbreak of Coronavirus disease 2019 (COVID-19) caused by the severe acute respiratory syndrome coronavirus 2 (SARS-Cov-2) initially emerged in Wuhan, China, and has spread worldwide no...

Authors: Jiao Liu, Sheng Zhang, Zhixiong Wu, You Shang, Xuan Dong, Guang Li, Lidi Zhang, Yizhu Chen, Xiaofei Ye, Hangxiang Du, Yongan Liu, Tao Wang, SiSi Huang, Limin Chen, Zhenliang Wen, Jieming Qu…

SARS-CoV-2 post-infective myocarditis: the tip of COVID-19 immune complications?

Recent paediatric cases of acute myocarditis following a SARS-CoV-2 infection have raised the possibility of post-infective complications of COVID-19. This short editorial is reviewing current understanding of...

Authors: Pierre Tissières and Jean-Louis Teboul

Management and prevention of anemia (acute bleeding excluded) in adult critical care patients

Anemia is very common in critical care patients, on admission (affecting about two-thirds of patients), but also during and after their stay, due to repeated blood loss, the effects of inflammation on erythrop...

Authors: Sigismond Lasocki, Frédéric Pène, Hafid Ait-Oufella, Cécile Aubron, Sylvain Ausset, Pierre Buffet, Olivier Huet, Yoann Launey, Matthieu Legrand, Thomas Lescot, Armand Mekontso Dessap, Michael Piagnerelli, Hervé Quintard, Lionel Velly, Antoine Kimmoun and Gérald Chanques

Advanced organ support (ADVOS) in the critically ill: first clinical experience in patients with multiple organ failure

Prevalence of multiple organ failure (MOF) in critically ill patients is increasing and associated mortality remains high. Extracorporeal organ support is a cornerstone in the management of MOF. We report data...

Authors: Valentin Fuhrmann, Theresa Weber, Kevin Roedl, Jasmin Motaabbed, Adel Tariparast, Dominik Jarczak, Aritz Perez Ruiz de Garibay, Johannes Kluwe, Olaf Boenisch, Harald Herkner, John A. Kellum and Stefan Kluge

Respiratory mechanics and gas exchanges in the early course of COVID-19 ARDS: a hypothesis-generating study

COVID-19 ARDS could differ from typical forms of the syndrome.

Authors: J.-L. Diehl, N. Peron, R. Chocron, B. Debuc, E. Guerot, C. Hauw-Berlemont, B. Hermann, J. L. Augy, R. Younan, A. Novara, J. Langlais, L. Khider, N. Gendron, G. Goudot, J.-F. Fagon, T. Mirault…

Pharmacokinetics of high-dose tigecycline in critically ill patients with severe infections

In critically ill patients, the use of high tigecycline dosages (HD TGC) (200 mg/day) has been recently increasing but few pharmacokinetic/pharmacodynamic (PK/PD) data are available. We designed a prospective ...

Authors: Gennaro De Pascale, Lucia Lisi, Gabriella Maria Pia Ciotti, Maria Sole Vallecoccia, Salvatore Lucio Cutuli, Laura Cascarano, Camilla Gelormini, Giuseppe Bello, Luca Montini, Simone Carelli, Valentina Di Gravio, Mario Tumbarello, Maurizio Sanguinetti, Pierluigi Navarra and Massimo Antonelli

Response to the letter of Morán et al. regarding our use of an inaccurate reference for the maximal dose of vitamin C in G6PD deficiency

Authors: Patrick M. Honore, Herbert D. Spapen, Paul Marik, Willem Boer and Heleen Oudemans-van Straaten

Performances of disseminated intravascular coagulation scoring systems in septic shock patients

There is no gold standard to diagnose septic shock-induced disseminated intravascular coagulation (DIC). The objective of our multicenter prospective study was to assess the performances of the different major...

Authors: Julie Helms, François Severac, Hamid Merdji, Raphaël Clere-Jehl, Bruno François, Emmanuelle Mercier, Jean-Pierre Quenot and Ferhat Meziani

Impact of the perioperative inotropic support in grown-up congenital heart patients undergoing cardiac surgery: a propensity score adjusted analysis

Grown-up congenital heart (GUCH) patients represent a growing population with a high morbidity risk when undergoing reparative surgery. A main preoperative feature is right ventricular failure, which represent...

Authors: Philippe Mauriat, Mirela Bojan, Sylvie Soulie, Hélène Foulgoc, Nadir Tafer and Alexandre Ouattara

Comparison of the proximal and distal approaches for axillary vein catheterization under ultrasound guidance (PANDA) in cardiac surgery patients susceptible to bleeding: a randomized controlled trial

The present study aimed at comparing the success rate and safety of proximal versus distal approach for ultrasound (US)-guided axillary vein catheterization (AVC) in cardiac surgery patients susceptible to ble...

Authors: Ying Su, Jun-yi Hou, Guo-guang Ma, Guang-wei Hao, Jing-chao Luo, Shen-ji Yu, Kai Liu, Ji-li Zheng, Yan Xue, Zhe Luo and Guo-wei Tu

Ultrasound guidance and risk for intravascular catheter-related infections among peripheral arterial catheters: a post-hoc analysis of two large randomized-controlled trials

The impact on infectious risk of ultrasound guidance at insertion remains controversial in short-term arterial catheters (ACs). The present study investigated the association between ultrasound guidance (US) d...

Authors: Niccolò Buetti, Stéphane Ruckly, Jean-Christophe Lucet, Lila Bouadma, Carole Schwebel, Olivier Mimoz and Jean-François Timsit

Spontaneous breathing, transpulmonary pressure and mathematical trickery

Authors: Luciano Gattinoni, John J. Marini, Mattia Busana, Davide Chiumello and Luigi Camporota

Commentary to “Dosing vitamin C in critically ill patients with special attention to renal replacement therapy: a narrative review”

Authors: J. M. Morán and I. Herrera-Peco

Clinical outcomes according to cannula configurations in patients with acute respiratory distress syndrome under veno-venous extracorporeal membrane oxygenation: a Korean multicenter study

Recirculation during veno-venous extracorporeal membrane oxygenation (VV-ECMO) is a known drawback that limits sufficient oxygenation. This study aimed to compare the short-term oxygenation and long-term morta...

Authors: Sung Yoon Lim, Soyeon Ahn, Sang-Bum Hong, Chi Ryang Chung, Kyeongman Jeon, Sang-Min Lee, Woo Hyun Cho, Sunghoon Park and Young-Jae Cho

Role of albumin in the preservation of endothelial glycocalyx integrity and the microcirculation: a review

The endothelial glycocalyx comprises a complex layer of membrane-bound proteoglycans, secreted glycosaminoglycans, glycoproteins, glycolipids and bound plasma proteins such as albumin and antithrombin associat...

Authors: Cesar Aldecoa, Juan V. Llau, Xavier Nuvials and Antonio Artigas

Ethical dilemmas due to the Covid-19 pandemic

The devastating pandemic that has stricken the worldwide population induced an unprecedented influx of patients in ICUs, raising ethical concerns not only surrounding triage and withdrawal of life support deci...

Authors: René Robert, Nancy Kentish-Barnes, Alexandre Boyer, Alexandra Laurent, Elie Azoulay and Jean Reignier

Multidisciplinary team approach in acute myocardial infarction patients undergoing veno-arterial extracorporeal membrane oxygenation

Limited data are available on the impact of a specialized extracorporeal membrane oxygenation (ECMO) team on clinical outcomes in patients with acute myocardial infarction (AMI) complicated by cardiogenic shoc...

Authors: David Hong, Ki Hong Choi, Yang Hyun Cho, Su Hyun Cho, So Jin Park, Darae Kim, Taek Kyu Park, Joo Myung Lee, Young Bin Song, Jin-Oh Choi, Joo-Yong Hahn, Seung-Hyuk Choi, Jin-Ho Choi, Kiick Sung, Hyeon-Cheol Gwon, Eun-Seok Jeon…

Impact of prior antibiotics on infected pancreatic necrosis microbiology in ICU patients: a retrospective cohort study

Recent guidelines advise against prophylactic antibiotics in patients with necrotizing pancreatitis, advocating instead a step-up drainage and necrosectomy strategy with antibiotics as dictated by microbiologi...

Authors: Charlotte Garret, Emmanuel Canet, Stéphane Corvec, David Boutoille, Matthieu Péron, Isabelle Archambeaud, Aurélie Le Thuaut, Jean-Baptiste Lascarrou, Frédéric Douane, Marc Lerhun, Nicolas Regenet, Emmanuel Coron and Jean Reignier

High-dose methotrexate in ICU patients: a retrospective study

High-dose methotrexate (HD-MTX) is commonly used in the treatment of solid tumors and hematological malignancies. Severe toxicities are frequent, leading to organ dysfunction and death. Risk–benefit ratio of u...

Authors: Sandrine Valade, Eric Mariotte, Elie Azoulay and Michael Darmon

Effects of endotoxin adsorber hemoperfusion on sublingual microcirculation in patients with septic shock: a randomized controlled trial

Endotoxins can induce an excessive inflammatory response and result in microcirculatory dysfunction. Polymyxin-B hemoperfusion (PMX-HP) has been recognized to effectively remove endotoxins in patients with sep...

Authors: Shih-Hong Chen, Wing-Sum Chan, Chih-Min Liu, Ching-Tang Chiu, Anne Chao, Vin-Cent Wu, Wang-Huei Sheng, Chien-Heng Lai, Ming-Jiuh Wang and Yu-Chang Yeh

A comparison of nasogastric tube insertion by SORT maneuver (sniffing position, NGT orientation, contralateral rotation, and twisting movement) versus neck flexion lateral pressure in critically ill patients admitted to ICU: a prospective randomized clinical trial

Although many techniques have been introduced to facilitate nasogastric tube (NGT) insertion using anatomic landmarks and a group of devices, there is a lack of general consensus regarding a standard method. T...

Authors: Sarvin Sanaie, Negin Mirzalou, Kamran Shadvar, Samad E. J. Golzari, Hassan Soleimanpour, Ali Shamekh, Deepti Bettampadi, Saeid Safiri and Ata Mahmoodpoor

Caution about early intubation and mechanical ventilation in COVID-19

Authors: Martin J. Tobin, Franco Laghi and Amal Jubran

Response to the authors

Authors: Pauline de Jager and Martin C. J. Kneyber

Letter to the Editor: Feasibility of an alternative, physiologic, individualized open-lung approach to high-frequency oscillatory ventilation in children

Authors: Arpita Chattopadhyay

Amikacin pharmacokinetic/pharmacodynamic in intensive care unit: a prospective database

Aminoglycosides have a concentration-dependent therapeutic effect when peak serum concentration (C_max) reaches eight to tenfold the minimal inhibitory concentration (MIC). With an amikacin MIC of 8 mg/L, the C_max

Authors: Elsa Logre, Maya Enser, Sébastien Tanaka, Marie Dubert, Aurore Claudinon, Nathalie Grall, Hervé Mentec, Philippe Montravers and Olivier Pajot

Mucormycosis in intensive care unit: surgery is a major prognostic factor in patients with hematological malignancy

Mucormycosis is an invasive fungal infection, with an increasing incidence especially in patients with hematological malignancies. Its prognosis is poor because of its high invasive power and its intrinsic low...

Authors: Johanna Claustre, Romaric Larcher, Thomas Jouve, Anne-Sophie Truche, Saad Nseir, Julien Cadiet, Yoann Zerbib, Alexandre Lautrette, Jean-Michel Constantin, Pierre-Emmanuel Charles, Cedric Daubin, Remi Coudroy, Jean Dellamonica, Laurent Argaud, Pierre Phelouzat, Damien Contou…

Management of critically ill patients with COVID-19 in ICU: statement from front-line intensive care experts in Wuhan, China

The ongoing coronavirus disease 2019 (COVID-2019) pandemic has swept all over the world, posing a great pressure on critical care resources due to large number of patients needing critical care. Statements fro...

Authors: You Shang, Chun Pan, Xianghong Yang, Ming Zhong, Xiuling Shang, Zhixiong Wu, Zhui Yu, Wei Zhang, Qiang Zhong, Xia Zheng, Ling Sang, Li Jiang, Jiancheng Zhang, Wei Xiong, Jiao Liu and Dechang Chen

Correction to: Early sepsis markers in patients admitted to intensive care unit with moderate‑to‑severe diabetic ketoacidosis

An amendment to this paper has been published and can be accessed via the original article.

Authors: Florian Blanchard, Judith Charbit, Guillaume Van der Meersch, Benjamin Popoff, Adrien Picod, Regis Cohen, Frank Chemouni, Stephane Gaudry, Helene Bihan and Yves Cohen

COVID-19-associated invasive pulmonary aspergillosis

Authors: Lynn Rutsaert, Nicky Steinfort, Tine Van Hunsel, Peter Bomans, Reinout Naesens, Helena Mertes, Hilde Dits and Niels Van Regenmortel

Journal club in an ICU: rate and factors associated with practice-changing articles. Analysis of 1712 articles read over a 13-year period (2007–2019)

Authors: Damien Contou, Marina Thirion, Olivier Pajot, Gaëtan Plantefève and Hervé Mentec

Acute myocarditis and multisystem inflammatory emerging disease following SARS-CoV-2 infection in critically ill children

A recent increase in children admitted with hypotensive shock and fever in the context of the COVID-19 outbreak requires an urgent characterization and assessment of the involvement of SARS-CoV-2 infection. Th...

Authors: Marion Grimaud, Julie Starck, Michael Levy, Clémence Marais, Judith Chareyre, Diala Khraiche, Marianne Leruez-Ville, Pierre Quartier, Pierre Louis Léger, Guillaume Geslain, Nada Semaan, Florence Moulin, Matthieu Bendavid, Sandrine Jean, Géraldine Poncelet, Sylvain Renolleau…

Organizational factors associated with adherence to low tidal volume ventilation: a secondary analysis of the CHECKLIST-ICU database

Survival benefit from low tidal volume (V_T) ventilation (LTVV) has been demonstrated for patients with acute respiratory distress syndrome (ARDS), and patients not having ARDS could also benefit from this strateg...

Authors: Thais Dias Midega, Fernando A. Bozza, Flávia Ribeiro Machado, Helio Penna Guimarães, Jorge I. Salluh, Antonio Paulo Nassar Jr., Karina Normílio-Silva, Marcus J. Schultz, Alexandre Biasi Cavalcanti and Ary Serpa Neto

Recruitment pattern of the diaphragm and extradiaphragmatic inspiratory muscles in response to different levels of pressure support

Inappropriate ventilator assist plays an important role in the development of diaphragm dysfunction. Ventilator under-assist may lead to muscle injury, while over-assist may result in muscle atrophy. This prov...

Authors: L. H. Roesthuis, J. G. van der Hoeven, H. W. H. van Hees, W.-J. M. Schellekens, J. Doorduin and L. M. A. Heunks

Duration of prone position sessions: a prospective cohort study

Prone position (PP) is highly recommended in moderate-to-severe ARDS. However, the optimal duration of PP sessions remains unclear. We searched to evaluate the time required to obtain the maximum physiological...

Authors: Sebastien Jochmans, Sandie Mazerand, Jonathan Chelly, Franck Pourcine, Oumar Sy, Nathalie Thieulot-Rolin, Olivier Ellrodt, Emmanuelle Mercier Des Rochettes, Gaël Michaud, Jean Serbource-Goguel, Christophe Vinsonneau, Ly Van Phach Vong and Mehran Monchi

The end-expiratory occlusion test for detecting preload responsiveness: a systematic review and meta-analysis

We performed a systematic review and meta-analysis of studies assessing the end-expiratory occlusion test (EEXPO test)-induced changes in cardiac output (CO) measured by any haemodynamic monitoring device, as ...

Authors: Francesco Gavelli, Rui Shi, Jean-Louis Teboul, Danila Azzolina and Xavier Monnet

Intravenous fluid therapy in the perioperative and critical care setting: Executive summary of the International Fluid Academy (IFA)

Intravenous fluid administration should be considered as any other pharmacological prescription. There are three main indications: resuscitation, replacement, and maintenance. Moreover, the impact of fluid adm...

Authors: Manu L. N. G. Malbrain, Thomas Langer, Djillali Annane, Luciano Gattinoni, Paul Elbers, Robert G. Hahn, Inneke De laet, Andrea Minini, Adrian Wong, Can Ince, David Muckart, Monty Mythen, Pietro Caironi and Niels Van Regenmortel

Lack of viral clearance by the combination of hydroxychloroquine and azithromycin or lopinavir and ritonavir in SARS-CoV-2-related acute respiratory distress syndrome

Authors: Sami Hraiech, Jérémy Bourenne, Khaldoun Kuteifan, Julie Helms, Julien Carvelli, Marc Gainnier, Ferhat Meziani and Laurent Papazian

Use, timing and factors associated with tracheal intubation in septic shock: a prospective multicentric observational study

No recommendation exists about the timing and setting for tracheal intubation and mechanical ventilation in septic shock.

Authors: C. Darreau, F. Martino, M. Saint-Martin, S. Jacquier, J. F. Hamel, M. A. Nay, N. Terzi, G. Ledoux, F. Roche-Campo, L. Camous, F. Pene, T. Balzer, F. Bagate, J. Lorber, P. Bouju, C. Marois…