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  1. Critical care randomized controlled trials (RCTs) are often published in high-impact journals, whether general journals [the New England Journal of Medicine (NEJM), The Lancet, the Journal of the American Medi...

    Authors: Joris Pensier, Audrey De Jong, Gerald Chanques, Emmanuel Futier, Elie Azoulay, Nicolas Molinari and Samir Jaber

    Citation: Annals of Intensive Care 2021 11:165

    Content type: Research

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  2. Optimal flow settings during high-flow nasal cannula (HFNC) therapy are unknown. We investigated the optimal flow settings during HFNC therapy based on breathing pattern and tidal inspiratory flows in patients...

    Authors: Jie Li, J. Brady Scott, James B. Fink, Brooke Reed, Oriol Roca and Rajiv Dhand

    Citation: Annals of Intensive Care 2021 11:164

    Content type: Research

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  3. Little is known about the effectiveness of surface cooling (SC) and endovascular cooling (EC) on the outcome of out-of-hospital cardiac arrest (OHCA) patients receiving target temperature management (TTM) acco...

    Authors: Makoto Watanabe, Tasuku Matsuyama, Hikaru Oe, Makoto Sasaki, Yuki Nakamura, Yuki Miyamoto, Nobunaga Okada, Tetsuhisa Kitamura and Bon Ohta

    Citation: Annals of Intensive Care 2021 11:163

    Content type: Research

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  4. The role of intravenous immunoglobulins (IVIG) during sepsis is controversial, as different trials on IVIG have observed inconsistent survival benefits. We aimed to elucidate the possible association and clini...

    Authors: Laura Alagna, Jennifer M. T. A. Meessen, Giacomo Bellani, Daniela Albiero, Pietro Caironi, Irene Principale, Luigi Vivona, Giacomo Grasselli, Francesca Motta, Nicolò M. Agnelli, Vieri Parrini, Stefano Romagnoli, Roberto Keim, Francesca Di Marzo Capozzi, Fabio S. Taccone, Walter Taccone…

    Citation: Annals of Intensive Care 2021 11:161

    Content type: Research

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  5. Ventilator-associated pneumonia (VAP) caused by Stenotrophomonas maltophilia is poorly described in the literature. However, it has been shown to be associated with increased morbidity and mortality. Probabilisti...

    Authors: Bérénice Puech, Clémence Canivet, Laura Teysseyre, Guillaume Miltgen, Thomas Aujoulat, Margot Caron, Chloé Combe, Julien Jabot, Olivier Martinet, Jerome Allyn, Cyril Ferdynus and Nicolas Allou

    Citation: Annals of Intensive Care 2021 11:160

    Content type: Research

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  6. Some unanswered questions persist regarding the effectiveness of corticosteroids for severe coronavirus disease 2019 (COVID-19) patients. We aimed to assess the clinical effect of corticosteroids on intensive ...

    Authors: Gerard Moreno, Raquel Carbonell, Ignacio Martin-Loeches, Jordi Solé-Violán, Eudald Correig i Fraga, Josep Gómez, Manuel Ruiz-Botella, Sandra Trefler, María Bodí, Josefa Murcia Paya, Emili Díaz, Pablo Vidal-Cortes, Elisabeth Papiol, Antonio Albaya Moreno, Susana Sancho Chinesta, Lorenzo Socias Crespi…

    Citation: Annals of Intensive Care 2021 11:159

    Content type: Research

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  7. Acute respiratory failure (ARF) in patients admitted to the intensive care unit (ICU) with known or de novo small-vessel vasculitis (Svv) may be secondary to the underlying immune disease or to other causes. E...

    Authors: Aude Gibelin, Guillaume Dumas, Sandrine Valade, Marc Pineton de Chambrun, François Bagate, Mathilde Neuville, Francis Schneider, Loredana Baboi, Matthieu Groh, Jean-Herlé Raphalen, Jean-Daniel Chiche, Nicolas De Prost, Charles-Edouard Luyt, Claude Guérin, Eric Maury, Etienne de Montmollin…

    Citation: Annals of Intensive Care 2021 11:158

    Content type: Research

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  8. Since March 2020, health care systems were importantly affected by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) outbreak, with some patients presenting severe acute respiratory distress syndrom...

    Authors: Florence Daviet, Philippe Guilloux, Sami Hraiech, David Tonon, Lionel Velly, Jeremy Bourenne, Alizée Porto, Inès Gragueb-Chatti, Mickael Bobot, Karine Baumstarck, Laurent Papazian, Frédéric Collart, Jean-Marie Forel and Christophe Guervilly

    Citation: Annals of Intensive Care 2021 11:157

    Content type: Research

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  9. Few data are available about outcomes of patients screened for, but not enrolled in, randomised clinical trials.

    Authors: J. B. Lascarrou, Gregoire Muller, Jean-Pierre Quenot, Nicolas Massart, Mickael Landais, Pierre Asfar, Jean-Pierre Frat, Jean-Charles Chakarian, Michel Sirodot, Bruno Francois, Guillaume Grillet, Sylvie Vimeux, Arnaud Delahaye, Stéphane Legriel, Didier Thevenin, Jean Reignier…

    Citation: Annals of Intensive Care 2021 11:156

    Content type: Research

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  10. Initial reports have described the poor outcome of unexpected cardiac arrest (CA) in intensive care unit (ICU) among COVID-19 patients in China and the USA. However, there are scarce data on characteristics an...

    Authors: Jonathan Chelly, Gaetan Plantefève, Toufik Kamel, Cédric Bruel, Saad Nseir, Christopher Lai, Giulia Cirillo, Elena Skripkina, Sébastien Ehrminger, Fernando-Daniel Berdaguer-Ferrari, Julien Le Marec, Marine Paul, Aurélie Autret and Nicolas Deye

    Citation: Annals of Intensive Care 2021 11:155

    Content type: Research

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  11. Baseline characteristics and disease severity of patients with septic shock according to the new Sepsis-3 definition may differ from patients that only comply with the Sepsis-2 definition. We conducted a retro...

    Authors: Joris Vermassen, Johan Decruyenaere, Liesbet De Bus, Pieter Depuydt and Kirsten Colpaert

    Citation: Annals of Intensive Care 2021 11:154

    Content type: Research

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  12. The potential relationship between intravascular catheter infections with their insertion during weekend or night-time (i.e., off-hours or not regular business hours) remains an open issue. Our primary aim was to...

    Authors: Niccolò Buetti, Stéphane Ruckly, Jean-Christophe Lucet, Arthur Mageau, Claire Dupuis, Bertrand Souweine, Olivier Mimoz and Jean-François Timsit

    Citation: Annals of Intensive Care 2021 11:153

    Content type: Research

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  13. COVID-19 is characterized by dysregulated immune response, respiratory failure and a relevant mortality rate among hospitalized patients. Interleukin-6 (IL-6) is involved in COVID-19-associated cytokine storm,...

    Authors: Alessandro Belletti, Corrado Campochiaro, Marilena Marmiere, Valery Likhvantsev, Andrey Yavorovskiy, Lorenzo Dagna, Giovanni Landoni, Alberto Zangrillo and Ludhmila Abrahão Hajjar

    Citation: Annals of Intensive Care 2021 11:152

    Content type: Research

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  14. The first wave of the COVID-19 pandemic confronted healthcare systems around the world with unprecedented organizational challenges, particularly regarding the availability of intensive care unit (ICU) beds. O...

    Authors: Marc-Antoine Sanchez, Albert Vuagnat, Olivier Grimaud, Emmanuelle Leray, Jean-Marc Philippe, François-Xavier Lescure, Mathieu Boutonnet, Hélène Coignard, Agnès Ricard Hibon, Stephane Sanchez and Julien Pottecher

    Citation: Annals of Intensive Care 2021 11:151

    Content type: Research

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  15. Prolonged need for mechanical ventilation greatly impacts life expectancy of patients after spinal cord injury (SCI). Weaning outcomes have never been systematically assessed. In this systematic review and met...

    Authors: Annia F. Schreiber, Jacopo Garlasco, Fernando Vieira, Yie Hui Lau, Dekel Stavi, David Lightfoot, Andrea Rigamonti, Karen Burns, Jan O. Friedrich, Jeffrey M. Singh and Laurent J. Brochard

    Citation: Annals of Intensive Care 2021 11:149

    Content type: Review

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  16. The presence of bacteraemia in pneumococcal pneumonia in critically ill patients does not appear to be a strong independent prognostic factor in the existing literature. However, there may be a specific patter...

    Authors: Hugo Bellut, Raphael Porcher, Emmanuelle Varon, Pierre Asfar, Yves Le Tulzo, Bruno Megarbane, Armelle Mathonnet, Anthony Dugard, Anne Veinstein, Kader Ouchenir, Shidasp Siami, Jean Reignier, Arnaud Galbois, Joël Cousson, Sébastien Preau, Olivier Baldesi…

    Citation: Annals of Intensive Care 2021 11:148

    Content type: Research

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  17. Ineffective triggering is frequent during pressure support ventilation (PSV) and may persist despite ventilator adjustment, leading to refractory asynchrony. We aimed to assess the effect of proportional assis...

    Authors: Anne-Fleur Haudebourg, Tommaso Maraffi, Samuel Tuffet, François Perier, Nicolas de Prost, Keyvan Razazi, Armand Mekontso Dessap and Guillaume Carteaux

    Citation: Annals of Intensive Care 2021 11:147

    Content type: Research

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  18. Echocardiographic parameters have been poorly investigated for estimating cardiovascular risk in patients with sepsis and new-onset atrial fibrillation. We aim to assess the prevalence of transesophageal echoc...

    Authors: Vincent Labbé, Stephane Ederhy, Nathanael Lapidus, Jérémie Joffre, Keyvan Razazi, Laurent Laine, Oumar Sy, Sebastian Voicu, Frank Chemouni, Nadia Aissaoui, Roland Smonig, Denis Doyen, Fabrice Carrat, Guillaume Voiriot, Armand Mekontso-Dessap, Ariel Cohen…

    Citation: Annals of Intensive Care 2021 11:146

    Content type: Research

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  19. In comatose patients receiving oro-tracheal intubation for mechanical ventilation (MV), the risk of aspiration is increased. Aspiration can lead to chemical pneumonitis (inflammatory reaction to the gastric co...

    Authors: Guylaine Labro, François Aptel, Marc Puyraveau, Jonathan Paillot, Sébastien Pili Floury, Hamid Merdji, Julie Helms, Gaël Piton, Fiona Ecarnot, Khaldoun Kuteifan, Jean Pierre Quenot and Gilles Capellier

    Citation: Annals of Intensive Care 2021 11:145

    Content type: Research

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  20. ICU-acquired weakness (ICUAW) has been shown to be associated with prolonged duration of mechanical ventilation and extubation failure. It is usually assessed through Medical Research Council (MRC) score, a ti...

    Authors: Guillaume Cottereau, Jonathan Messika, Bruno Megarbane, Laurent Guérin, Daniel da Silva, Caroline Bornstain, Matilde Santos, Jean-Damien Ricard and Benjamin Sztrymf

    Citation: Annals of Intensive Care 2021 11:144

    Content type: Research

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  21. Information is lacking regarding long-term survival and predictive factors for mortality in patients with acute hypoxemic respiratory failure due to coronavirus disease 2019 (COVID-19) and undergoing invasive ...

    Authors: Oscar Peñuelas, Laura del Campo-Albendea, Amanda Lesmes González de Aledo, José Manuel Añón, Carmen Rodríguez-Solís, Jordi Mancebo, Paula Vera, Daniel Ballesteros, Jorge Jiménez, Emilio Maseda, Juan Carlos Figueira, Nieves Franco, Ángela Algaba, Juan Pablo Avilés, Ricardo Díaz, Beatriz Abad…

    Citation: Annals of Intensive Care 2021 11:143

    Content type: Research

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  22. A delay in admission to the intensive care unit (ICU) of patients with community-acquired pneumonia (CAP) has been associated with an increased mortality. Decisions regarding interventions and eligibility for ...

    Authors: Liza Pereverzeva, Fabrice Uhel, Hessel Peters Sengers, Olaf L. Cremer, Marcus J. Schultz, Marc M. J. Bonten, Brendon P. Scicluna and Tom van der Poll

    Citation: Annals of Intensive Care 2021 11:142

    Content type: Research

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  23. Polymyxin B hemoperfusion (PMX) aims to treat septic shock by removing endotoxin from the patient’s blood. However, the relationship between the severity of the patient's organ damage and the survival benefit ...

    Authors: Kenji Fujimori, Kunio Tarasawa and Kiyohide Fushimi

    Citation: Annals of Intensive Care 2021 11:141

    Content type: Research

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  24. Myoglobin and creatine kinase (CK) are both established markers of muscle injury but their hospital admission values have never been compared to predict post-traumatic acute kidney injury (AKI).

    Authors: Virginie Tarazona, Samy Figueiredo, Sophie Hamada, Jonas Pochard, Ryan W. Haines, John R. Prowle, Jacques Duranteau, Bernard Vigué and Anatole Harrois

    Citation: Annals of Intensive Care 2021 11:140

    Content type: Research

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  25. The optimal mean arterial pressure (MAP) in cases of septic shock is still a matter of debate in patients with prior hypertension. An MAP between 75 and 85 mmHg can improve glomerular filtration rate (GFR) but...

    Authors: Antoine Dewitte, Aurore Labat, Pierre-Antoine Duvignaud, Gauthier Bouche, Olivier Joannes-Boyau, Jean Ripoche, Gilles Hilbert, Didier Gruson, Sébastien Rubin, Alexandre Ouattara, Alexandre Boyer and Christian Combe

    Citation: Annals of Intensive Care 2021 11:139

    Content type: Research

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  26. Invasive pulmonary aspergillosis (IPA) has always been a challenging diagnosis and risk factors an important guide to investigate specific population, especially in Intensive Care Unit. Traditionally recognize...

    Authors: G. Montrucchio, T. Lupia, D. Lombardo, G. Stroffolini, S. Corcione, F. G. De Rosa and L. Brazzi

    Citation: Annals of Intensive Care 2021 11:136

    Content type: Review

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  27. High-flow nasal oxygen cannula (HFNC) and noninvasive mechanical ventilation (NIV) can prevent reintubation in critically ill patients. However, their efficacy in post-extubated sepsis patients remains unclear...

    Authors: Surat Tongyoo, Porntipa Tantibundit, Kiattichai Daorattanachai, Tanuwong Viarasilpa, Chairat Permpikul and Suthipol Udompanturak

    Citation: Annals of Intensive Care 2021 11:135

    Content type: Research

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  28. The aim of this study was to validate whether regional ventilation and perfusion data measured by electrical impedance tomography (EIT) with saline bolus could discriminate three broad acute respiratory failur...

    Authors: Huaiwu He, Yi Chi, Yun Long, Siyi Yuan, Rui Zhang, Yingying Yang, Inéz Frerichs, Knut Möller, Feng Fu and Zhanqi Zhao

    Citation: Annals of Intensive Care 2021 11:134

    Content type: Research

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  29. The end-expiratory occlusion (EEXPO) test detects preload responsiveness, but it is 15 s long and induces small changes in cardiac index (CI). It is doubtful whether the Starling bioreactance device, which ave...

    Authors: Francesco Gavelli, Alexandra Beurton, Jean-Louis Teboul, Nello De Vita, Danila Azzolina, Rui Shi, Arthur Pavot and Xavier Monnet

    Citation: Annals of Intensive Care 2021 11:133

    Content type: Research

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  30. Cardiogenic pulmonary oedema (CPE) may contribute to ventilator-associated lung injury (VALI) in patients with cardiogenic shock. The appropriate ventilatory strategy remains unclear. We aimed to evaluate the ...

    Authors: Laura Amado-Rodríguez, Cecilia Del Busto, Inés López-Alonso, Diego Parra, Juan Mayordomo-Colunga, Miguel Arias-Guillén, Rodrigo Albillos-Almaraz, Paula Martín-Vicente, Cecilia López-Martínez, Covadonga Huidobro, Luigi Camporota, Arthur S. Slutsky and Guillermo M. Albaiceta

    Citation: Annals of Intensive Care 2021 11:132

    Content type: Research

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  31. Severe infections and multidrug-resistant pathogens are common in critically ill patients. Antimicrobial stewardship (AMS) and therapeutic drug monitoring (TDM) are contemporary tools to optimize the use of an...

    Authors: Christian Lanckohr, Christian Boeing, Jan J. De Waele, Dylan W. de Lange, Jeroen Schouten, Menno Prins, Maarten Nijsten, Pedro Povoa, Andrew Conway Morris and Hendrik Bracht

    Citation: Annals of Intensive Care 2021 11:131

    Content type: Research

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  32. Acute gastrointestinal bleeding (GIB) may be a severe condition in immunocompromised patients and may require intensive care unit (ICU) admission. We aimed to describe the clinical spectrum of critically ill i...

    Authors: Jennifer Catano, Sophie Caroline Sacleux, Jean-Marc Gornet, Marine Camus, Naike Bigé, Faouzi Saliba, Elie Azoulay, Guillaume Dumas and Lara Zafrani

    Citation: Annals of Intensive Care 2021 11:130

    Content type: Research

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  33. Precision medicine risk stratification is desperately needed to both avoid systemic antifungals treatment delay and over prescription in the critically ill with risk factors. The aim of the present study was t...

    Authors: Boris Jung, Clément Le Bihan, Pierre Portales, Nathalie Bourgeois, Thierry Vincent, Laurence Lachaud, Gerald Chanques, Matthieu Conseil, Philippe Corne, Pablo Massanet, Jean François Timsit and Samir Jaber

    Citation: Annals of Intensive Care 2021 11:129

    Content type: Research

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  34. Lactate is an established prognosticator in critical care. However, there still is insufficient evidence about its role in predicting outcome in COVID-19. This is of particular concern in older patients who ha...

    Authors: Raphael Romano Bruno, Bernhard Wernly, Hans Flaatten, Jesper Fjølner, Antonio Artigas, Bernardo Bollen Pinto, Joerg C. Schefold, Stephan Binnebössel, Philipp Heinrich Baldia, Malte Kelm, Michael Beil, Sivri Sigal, Peter Vernon van Heerden, Wojciech Szczeklik, Muhammed Elhadi, Michael Joannidis…

    Citation: Annals of Intensive Care 2021 11:128

    Content type: Research

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  35. The COVID-19 sanitary crisis inflicted different challenges regarding the reorganization of the human and logistic resources, particularly in intensive care unit (ICU). Interdependence between regional pandemi...

    Authors: Antoine Guillon, Emeline Laurent, Antoine Duclos, Lucile Godillon, Pierre-François Dequin, Nelly Agrinier, Antoine Kimmoun and Leslie Grammatico-Guillon

    Citation: Annals of Intensive Care 2021 11:127

    Content type: Research

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  36. Videolaryngoscopes with an operating channel may improve the intubation success rate in critically ill patients. We aimed to compare four channelled videolaryngoscopes to the Macintosh laryngoscope used for in...

    Authors: Paul Decamps, Nicolas Grillot, Aurelie Le Thuaut, Noelle Brule, Corinne Lejus-Bourdeau, Jean Reignier and Jean-Baptiste Lascarrou

    Citation: Annals of Intensive Care 2021 11:126

    Content type: Research

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  37. Very few studies assessed the association between Intensive Care Unit (ICU) triage decisions and mortality. The aim of this study was to assess whether an association could be found between 30-day mortality, a...

    Authors: Esther N. van der Zee, Dominique D. Benoit, Marinus Hazenbroek, Jan Bakker, Erwin J. O. Kompanje, Nuray Kusadasi and Jelle L. Epker

    Citation: Annals of Intensive Care 2021 11:125

    Content type: Research

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  38. The current Berlin definition of acute respiratory distress syndrome (ARDS) uses the PaO2/FiO2 (P/F) ratio to classify severity. However, for the same P/F ratio, a patient on a higher positive end-expiratory pres...

    Authors: Sunitha Palanidurai, Jason Phua, Yiong Huak Chan and Amartya Mukhopadhyay

    Citation: Annals of Intensive Care 2021 11:124

    Content type: Research

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    The Letter to the Editor to this article has been published in Annals of Intensive Care 2021 11:137

  39. There are limited data on acute kidney injury (AKI) progression and long-term outcomes in critically ill patients with coronavirus disease-19 (COVID-19). We aimed to describe the prevalence and risk factors fo...

    Authors: Nuttha Lumlertgul, Leah Pirondini, Enya Cooney, Waisun Kok, John Gregson, Luigi Camporota, Katie Lane, Richard Leach and Marlies Ostermann

    Citation: Annals of Intensive Care 2021 11:123

    Content type: Research

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  40. Coronavirus disease has heterogeneous clinical features; however, the reasons for the heterogeneity are poorly understood. This study aimed to identify clinical phenotypes according to patients’ temperature tr...

    Authors: Yanfei Shen, Dechang Chen, Xinmei Huang, Guolong Cai, Qianghong Xu, Caibao Hu, Jing Yan and Jiao Liu

    Citation: Annals of Intensive Care 2021 11:121

    Content type: Research

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  41. Whether Intensive Care Unit (ICU) clinicians display unconscious bias towards cancer patients is unknown. The aim of this study was to compare the outcomes of critically ill patients with and without perceptio...

    Authors: Dominique D. Benoit, Esther N. van der Zee, Michael Darmon, An K. L. Reyners, Victoria Metaxa, Djamel Mokart, Alexander Wilmer, Pieter Depuydt, Andreas Hvarfner, Katerina Rusinova, Jan G. Zijlstra, François Vincent, Dimitrios Lathyris, Anne-Pascale Meert, Jacques Devriendt, Emma Uyttersprot…

    Citation: Annals of Intensive Care 2021 11:120

    Content type: Research

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  42. Dynamic arterial elastance (Eadyn) has been extensively considered as a functional parameter of arterial load. However, conflicting evidence has been obtained on the ability of Eadyn to predict mean arterial pres...

    Authors: Xiaoyang Zhou, Weihao Pan, Bixin Chen, Zhaojun Xu and Jianneng Pan

    Citation: Annals of Intensive Care 2021 11:119

    Content type: Research

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  43. Many patients with coronavirus disease 2019 (COVID-19) required critical care. Mid-term outcomes of the survivors need to be assessed. The objective of this single-center cohort study was to describe their phy...

    Authors: Anne-Françoise Rousseau, Pauline Minguet, Camille Colson, Isabelle Kellens, Sourour Chaabane, Pierre Delanaye, Etienne Cavalier, J. Geoffrey Chase, Bernard Lambermont and Benoit Misset

    Citation: Annals of Intensive Care 2021 11:118

    Content type: Research

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  44. At the critical care level, the flu surveillance system is limited in France, with heterogeneous regional modalities of implementation.

    Authors: Muriel Fartoukh, Guillaume Voiriot, Laurent Guérin, Jean Damien Ricard, Alain Combes, Morgane Faure, Sarah Benghanem, Etienne de Montmollin, Yacine Tandjaoui-Lambiotte, Antoine Vieillard-Baron, Eric Maury, Jean-Luc Diehl, Keyvan Razazi, Virginie Lemiale, Pierre Trouiller, Benjamin Planquette…

    Citation: Annals of Intensive Care 2021 11:117

    Content type: Research

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  45. Percutaneous dilatational tracheotomy (PDT) has become an established procedure in intensive care units (ICU). However, the safety of this method has been under debate given the growing number of critically il...

    Authors: Enzo Lüsebrink, Alexander Krogmann, Franziska Tietz, Matthias Riebisch, Rainer Okrojek, Friedhelm Peltz, Carsten Skurk, Carsten Hullermann, Jan Sackarnd, Dietmar Wassilowsky, Karl Toischer, Clemens Scherer, Michael Preusch, Christoph Testori, Ulrike Flierl, Sven Peterss…

    Citation: Annals of Intensive Care 2021 11:116

    Content type: Research

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