Articles

Response to: 500 mg as bolus followed by an extended infusion of 1500 mg of meropenem every 8 h failed to achieve in one-third of the patients an optimal PK/PD against nonresistant strains of these organisms: is CRRT responsible for this situation?

Authors: Amol Kothekar, Jigeeshu Vasishtha Divatia, Sheila Nainan Myatra and Vikram Gota

500 mg as bolus followed by an extended infusion of 1500 mg of meropenem every 8 h failed to achieve in one-third of the patients an optimal PK/PD against non-resistant strains of these organisms: is CRRT responsible for this situation?

Authors: Patrick M. Honore, Leonel Barret Gutierrez, Luc Kugener, Sebastien Redant, Rachid Attou, Andrea Gallerani and David De Bels

SORT as any easy technique to do; but needs more trials to be as a routine practice

Authors: Sarvin Sanaie and Ata Mahmoodpoor

Feasibility, safety, and resource utilisation of active mobilisation of patients on extracorporeal life support: a prospective observational study

There is scarce evidence on the feasibility, safety and resource utilisation of active mobilisation in critically ill patients on extracorporeal life support (ECLS).

Authors: Stephan Braune, Patrick Bojes, Anne Mecklenburg, Federico Angriman, Gerold Soeffker, Katja Warnke, Dirk Westermann, Stefan Blankenberg, Mathias Kubik, Hermann Reichenspurner and Stefan Kluge

SORT maneuver: ease and safety for the practitioner and the patient

Authors: Mahdi Najafi

The effect of bed-to-nurse ratio on hospital mortality of critically ill children on mechanical ventilation: a nationwide population-based study

Despite the high workload of mechanical ventilation, there has been a lack of studies on the association between nurse workforce and mortality in mechanically ventilated patients. We evaluated the association ...

Authors: Minyoung Jung, Hyejeong Park, Danbee Kang, Esther Park, Kyeongman Jeon, Chi Ryang Chung, Jeong Hoon Yang, Gee Young Suh, Eliseo Guallar, Juhee Cho and Joongbum Cho

Ventilator-associated pneumonia in patients with SARS-CoV-2-associated acute respiratory distress syndrome requiring ECMO: a retrospective cohort study

The data on incidence, clinical presentation, and outcomes of ventilator-associated pneumonia (VAP) in patients with severe coronavirus disease 2019 (COVID-19) pneumonia requiring mechanical ventilation (MV) a...

Authors: Charles-Edouard Luyt, Tarek Sahnoun, Melchior Gautier, Pauline Vidal, Sonia Burrel, Marc Pineton de Chambrun, Juliette Chommeloux, Cyrielle Desnos, Jeremy Arzoine, Ania Nieszkowska, Nicolas Bréchot, Matthieu Schmidt, Guillaume Hekimian, David Boutolleau, Jérôme Robert, Alain Combes…

Management of pharmaceutical and recreational drug poisoning

Poisoning is one of the leading causes of admission to the emergency department and intensive care unit. A large number of epidemiological changes have occurred over the last years such as the exponential grow...

Authors: Bruno Mégarbane, Mathieu Oberlin, Jean-Claude Alvarez, Frederic Balen, Sébastien Beaune, Régis Bédry, Anthony Chauvin, Isabelle Claudet, Vincent Danel, Guillaume Debaty, Arnaud Delahaye, Nicolas Deye, Jean-Michel Gaulier, Francis Grossenbacher, Philippe Hantson, Frédéric Jacobs…

P-SILI as justification for intubation in COVID-19: readers as arbiters

Authors: Martin J. Tobin, Amal Jubran and Franco Laghi

Effectiveness of corticosteroids for post-extubation stridor and extubation failure in pediatric patients: a systematic review and meta-analysis

While the results of previous meta-analyses have shown beneficial effects of corticosteroid therapy on post-extubation stridor and extubation failure in adults, these results might not be generalizable to chil...

Authors: Satoshi Kimura, JiYoon B. Ahn, Mai Takahashi, Sohee Kwon and Stefania Papatheodorou

Adsorption therapy in critically ill with septic shock and acute kidney injury: a retrospective and prospective cohort study

Haemoadsorption has been described as an effective way to control increased pro- and anti-inflammatory mediators (“cytokine storm”) in septic shock patients. No prospective or randomised clinical study has yet...

Authors: Gregor A. Schittek, Philipp Zoidl, Michael Eichinger, Simon Orlob, Holger Simonis, Martin Rief, Philipp Metnitz, Tobias Fellinger and Jens Soukup

Physiologic responses to a staircase lung volume optimization maneuver in pediatric high-frequency oscillatory ventilation

Titration of the continuous distending pressure during a staircase incremental–decremental pressure lung volume optimization maneuver in children on high-frequency oscillatory ventilation is traditionally driv...

Authors: Pauline de Jager, Johannes G. M. Burgerhof, Alette A. Koopman, Dick G. Markhorst and Martin C. J. Kneyber

Retinal blood flow in critical illness and systemic disease: a review

Assessment and maintenance of end-organ perfusion are key to resuscitation in critical illness, although there are limited direct methods or proxy measures to assess cerebral perfusion. Novel non-invasive meth...

Authors: E. Courtie, T. Veenith, A. Logan, A. K. Denniston and R. J. Blanch

Rescue therapy with inhaled nitric oxide and almitrine in COVID-19 patients with severe acute respiratory distress syndrome

In COVID-19 patients with severe acute respiratory distress syndrome (ARDS), the relatively preserved respiratory system compliance despite severe hypoxemia, with specific pulmonary vascular dysfunction, sugge...

Authors: François Bagate, Samuel Tuffet, Paul Masi, François Perier, Keyvan Razazi, Nicolas de Prost, Guillaume Carteaux, Didier Payen and Armand Mekontso Dessap

Effects of capillary refill time-vs. lactate-targeted fluid resuscitation on regional, microcirculatory and hypoxia-related perfusion parameters in septic shock: a randomized controlled trial

Persistent hyperlactatemia has been considered as a signal of tissue hypoperfusion in septic shock patients, but multiple non-hypoperfusion-related pathogenic mechanisms could be involved. Therefore, pursuing ...

Authors: Ricardo Castro, Eduardo Kattan, Giorgio Ferri, Ronald Pairumani, Emilio Daniel Valenzuela, Leyla Alegría, Vanessa Oviedo, Nicolás Pavez, Dagoberto Soto, Magdalena Vera, César Santis, Brusela Astudillo, María Alicia Cid, Sebastian Bravo, Gustavo Ospina-Tascón, Jan Bakker…

Impact of systematic screening for AmpC-hyperproducing Enterobacterales intestinal carriage in intensive care unit patients

Empirical antimicrobial therapy (EAT) is a challenge for community-acquired, hospital-acquired and ventilator-associated pneumonia, particularly in the context of the increasing occurrence of third-generation ...

Authors: Manquat Elsa, Le Dorze Matthieu, Pean De Ponfilly Gauthier, Benmansour Hanaa, Amarsy Rishma, Cambau Emmanuelle, Soyer Benjamin, Chousterman Benjamin Glenn and Jacquier Hervé

Irrespective of the degree of hyperlactatemia, similar lactate levels were associated with a lower mortality rate in metformin users compared with non-users: beware of confounders!

Authors: Patrick M. Honore, Leonel Barreto Gutierrez, Luc Kugener, Sebastien Redant, Rachid Attou, Andrea Gallerani and David De Bels

Comment on “Respiratory mechanics and gas exchanges in the early course of COVID-19 ARDS: a hypothesis-generating study”

Authors: Elisa Damiani, Andrea Carsetti, Erika Casarotta, Roberta Domizi, Claudia Scorcella, Erica Adrario and Abele Donati

Acute respiratory failure in immunocompromised patients: outcome and clinical features according to neutropenia status

The impact of neutropenia in critically ill immunocompromised patients admitted in a context of acute respiratory failure (ARF) remains uncertain. The primary objective was to assess the prognostic impact of n...

Authors: Djamel Mokart, Michael Darmon, Peter Schellongowski, Peter Pickkers, Marcio Soares, Jordi Rello, Philippe R. Bauer, Andry van de Louw, Virginie Lemiale, Fabio Silvio Taccone, Ignacio Martin-Loeches, Jorge Salluh, Katerina Rusinova, Sangeeta Mehta, Massimo Antonelli, Achille Kouatchet…

Sepsis and septic shock in France: incidences, outcomes and costs of care

Sepsis is one of the leading causes of death worldwide. The associated incidence, mortality and trends do not differ greatly between documented reports. The purpose of this study was to provide an in-depth des...

Authors: Claire Dupuis, Lila Bouadma, Stéphane Ruckly, Anne Perozziello, Damien Van-Gysel, Arthur Mageau, Bruno Mourvillier, Etienne de Montmollin, Sébastien Bailly, Gregory Papin, Fabrice Sinnah, Camille Vinclair, Sonia Abid, Romain Sonneville and Jean-François Timsit

Patient–ventilator asynchrony in acute brain-injured patients: a prospective observational study

Patient–ventilator asynchrony is common in mechanically ventilated patients and may be related to adverse outcomes. Few studies have reported the occurrence of asynchrony in brain-injured patients. We aimed to...

Authors: Xu-Ying Luo, Xuan He, Yi-Min Zhou, Yu-Mei Wang, Jing-Ran Chen, Guang-Qiang Chen, Hong-Liang Li, Yan-Lin Yang, Linlin Zhang and Jian-Xin Zhou

Immune-related adverse events: a retrospective look into the future of oncology in the intensive care unit

Immune checkpoint inhibitors have reshaped the standard of care in oncology. However, they have been associated with potentially life-threatening immune-related adverse events. With the growing indications of ...

Authors: Adrien Joseph, Audrey Simonaggio, Annabelle Stoclin, Antoine Vieillard-Baron, Guillaume Geri, Stéphane Oudard, Jean-Marie Michot, Olivier Lambotte, Elie Azoulay and Virginie Lemiale

Epidemiology, clinical characteristics, and outcome of candidemia in critically ill patients in Germany: a single-center retrospective 10-year analysis

Despite advances in the management of bloodstream infections (BSI) caused by Candida spp., the mortality still remains high in critically ill patients. The worldwide epidemiology of yeast-related BSI is subject t...

Authors: Maria Schroeder, Theresa Weber, Timme Denker, Sarah Winterland, Dominic Wichmann, Holger Rohde, Ann-Kathrin Ozga, Marlene Fischer and Stefan Kluge

Biased and unbiased estimation of the average length of stay in intensive care units in the Covid-19 pandemic

The average length of stay (LOS) in the intensive care unit (ICU_ALOS) is a helpful parameter summarizing critical bed occupancy. During the outbreak of a novel virus, estimating early a reliable ICU_ALOS esti...

Authors: Nathanael Lapidus, Xianlong Zhou, Fabrice Carrat, Bruno Riou, Yan Zhao and Gilles Hejblum

Tigecycline pharmacokinetics in critically ill patients on renal replacement therapy: possible warnings and potential perspectives for the research agenda

Authors: Salvatore Lucio Cutuli, Gennaro De Pascale, Lucia Lisi, Simone Carelli, Pierluigi Navarra and Massimo Antonelli

Response to Damiani and colleagues

Authors: J-L Diehl, N. Peron, A. Philippe and D. M. Smadja

High doses of tigecycline are associated with satisfactory plasmatic and pulmonary concentrations for the treatment of severe infections due to fully susceptible bacteria: do we need even higher doses in patients under CRRT?

Authors: Patrick M. Honore, Leonel Barreto Gutierrez, Luc Kugener, Sebastien Redant, Rachid Attou, Andrea Gallerani and David De Bels

Persistent swallowing disorders after extubation in mechanically ventilated patients in ICU: a two-center prospective study

Persistent swallowing disorders (SD) are non-pulmonary complications of mechanical ventilation (MV). However, there are few clinical studies on persistent SD in critically ill patients undergoing tracheal intu...

Authors: G. Beduneau, V. Souday, J. C. Richard, J. F. Hamel, D. Carpentier, J. M. Chretien, P. Bouchetemble, L. Laccoureye, A. Astier, V. Tanguy, A. Mercat, F. Beloncle and F. Tamion

pCLIF-SOFA is a reliable outcome prognostication score of critically ill children with cirrhosis: an ESPNIC multicentre study

Data on outcome of critically ill children with cirrhosis are scarce. We aimed to evaluate the prognostic accuracy of sequential organs scoring systems in children with cirrhosis admitted to Paediatric Intensi...

Authors: Caroline Claude, Akash Deep, Martin Kneyber, Salman Siddiqui, Sylvain Renolleau, Luc Morin, Emmanuel Jacquemin, Jean-Paul Teglas, Vincent Gajdos, Pierre Tissières and Philippe Durand

Treatment variables associated with outcome in emergency department patients with suspected sepsis

Early treatment is advocated in the management of patients with suspected sepsis in the emergency department (ED). We sought to understand the association between the ED treatments and outcome in patients admi...

Authors: Narani Sivayoham, Lesley A. Blake, Shafi E. Tharimoopantavida, Saad Chughtai, Adil N. Hussain and Andrew Rhodes

COVID-19: scientific reasoning, pragmatism and emotional bias

Authors: Luciano Gattinoni, John J. Marini, Davide Chiumello, Mattia Busana and Luigi Camporota

Use of critical care resources during the first 2 weeks (February 24–March 8, 2020) of the Covid-19 outbreak in Italy

A Covid-19 outbreak developed in Lombardy, Veneto and Emilia-Romagna (Italy) at the end of February 2020. Fear of an imminent saturation of available ICU beds generated the notion that rationing of intensive c...

Authors: Tommaso Tonetti, Giacomo Grasselli, Alberto Zanella, Giacinto Pizzilli, Roberto Fumagalli, Simone Piva, Luca Lorini, Giorgio Iotti, Giuseppe Foti, Sergio Colombo, Luigi Vivona, Sandra Rossi, Massimo Girardis, Vanni Agnoletti, Anselmo Campagna, Giovanni Gordini…

Best-practice IgM- and IgA-enriched immunoglobulin use in patients with sepsis

Sepsis is a life-threatening organ dysfunction caused by a dysregulated host response to infection. Despite treatment being in line with current guidelines, mortality remains high in those with septic shock. I...

Authors: Axel Nierhaus, Giorgio Berlot, Detlef Kindgen-Milles, Eckhard Müller and Massimo Girardis

Characteristics and outcomes of acute respiratory distress syndrome related to COVID-19 in Belgian and French intensive care units according to antiviral strategies: the COVADIS multicentre observational study

Limited data are available regarding antiviral therapy efficacy in most severe patients under mechanical ventilation for Covid-19-related acute respiratory distress syndrome (ARDS).

Authors: David Grimaldi, Nadia Aissaoui, Gauthier Blonz, Giuseppe Carbutti, Romain Courcelle, Stephane Gaudry, Aurelie Gaultier, Alain D’hondt, Julien Higny, Geoffrey Horlait, Sami Hraiech, Laurent Lefebvre, Francois Lejeune, Andre Ly, Michael Piagnerelli, Bertrand Sauneuf…

Intra-abdominal hypertension and abdominal compartment syndrome in patients admitted to the ICU

Intra-abdominal hypertension is frequently present in critically ill patients and is an independent predictor for mortality. Risk factors for intra-abdominal hypertension and abdominal compartment syndrome hav...

Authors: Marije Smit, Bart Koopman, Willem Dieperink, Jan B. F. Hulscher, H. Sijbrand Hofker, Matijs van Meurs and Jan G. Zijlstra

Transpulmonary pressures in obese and non-obese COVID-19 ARDS

Data on respiratory mechanics of COVID-19 ARDS patients are scarce. Respiratory mechanics and response to positive expiratory pressure (PEEP) may be different in obese and non-obese patients.

Authors: Mehdi Mezidi, Florence Daviet, Paul Chabert, Sami Hraiech, Laurent Bitker, Jean-Marie Forel, Hodane Yonis, Ines Gragueb, Francois Dhelft, Laurent Papazian, Jean-Christophe Richard and Christophe Guervilly

Early mechanical ventilation in patients with Guillain-Barré syndrome at high risk of respiratory failure: a randomized trial

About 30% of patients with Guillain-Barré syndrome become ventilator dependent, of whom roughly 75% develop pneumonia. This trial aimed at assessing the impact of early mechanical ventilation (EMV) on pneumoni...

Authors: Marie-Anne Melone, Nicholas Heming, Paris Meng, Dominique Mompoint, Jerôme Aboab, Bernard Clair, Jerôme Salomon, Tarek Sharshar, David Orlikowski, Sylvie Chevret and Djillali Annane

Vitamins as adjunctive treatment for coronavirus disease!

Authors: Indu Kapoor, Hemanshu Prabhakar and Charu Mahajan

Physiological effects of adding ECCO₂R to invasive mechanical ventilation for COPD exacerbations

Extracorporeal CO₂ removal (ECCO₂R) could be a valuable additional modality for invasive mechanical ventilation (IMV) in COPD patients suffering from severe acute exacerbation (AE). We aimed to evaluate in such p...

Authors: J.-L. Diehl, L. Piquilloud, D. Vimpere, N. Aissaoui, E. Guerot, J. L. Augy, M. Pierrot, D. Hourton, A. Arnoux, C. Richard, J. Mancebo and A. Mercat

Surgical mask on top of high-flow nasal cannula improves oxygenation in critically ill COVID-19 patients with hypoxemic respiratory failure

Critically ill patients admitted in ICU because of COVID-19 infection display severe hypoxemic respiratory failure. The Surviving Sepsis Campaign recommends oxygenation through high-flow nasal cannula over non...

Authors: Virginie Montiel, Arnaud Robert, Annie Robert, Anas Nabaoui, Tourneux Marie, Natalia Morales Mestre, Maerckx Guillaume, Pierre-François Laterre and Xavier Wittebole

Pulmonary embolism in patients with coronavirus disease-2019 (COVID-19) pneumonia: a narrative review

Preliminary reports have described significant procoagulant events in patients with coronavirus disease-2019 (COVID-19), including life-threatening pulmonary embolism (PE).

Authors: Yasser Sakr, Manuela Giovini, Marc Leone, Giacinto Pizzilli, Andreas Kortgen, Michael Bauer, Tommaso Tonetti, Gary Duclos, Laurent Zieleskiewicz, Samuel Buschbeck, V. Marco Ranieri and Elio Antonucci

Respiratory virus-associated infections in HIV-infected adults admitted to the intensive care unit for acute respiratory failure: a 6-year bicenter retrospective study (HIV-VIR study)

Acute respiratory failure is the main reason for admission to the intensive care unit (ICU) in HIV-infected adults. There is little data about the epidemiology of respiratory viruses in this population.

Authors: Alexandre Elabbadi, Jérémie Pichon, Benoit Visseaux, Aurélie Schnuriger, Lila Bouadma, Quentin Philippot, Juliette Patrier, Vincent Labbé, Stéphane Ruckly, Muriel Fartoukh, Jean-François Timsit and Guillaume Voiriot

A preliminary study of intensivist-performed DVT ultrasound screening in trauma ICU patients (APSIT Study)

Multiple screening Duplex ultrasound scans (DUS) are performed in trauma patients at high risk of deep vein thrombosis (DVT) in the intensive care unit (ICU). Intensive care physician performed compression ult...

Authors: Lloyd Roberts, Tom Rozen, Deirdre Murphy, Adam Lawler, Mark Fitzgerald, Harry Gibbs, Kyle Brooks, Joshua F. Ihle, Tim Leong, Judit Orosz, Eldho Paul and Vinodh Bhagyalakshmi Nanjayya

Potential risks in using midodrine for persistent hypotension after cardiac surgery: a comparative cohort study

Persistent hypotension is a frequent complication after cardiac surgery with cardiopulmonary bypass (CPB). Midodrine, an orally administered alpha agonist, could potentially reduce intravenous vasopressor use ...

Authors: Jan-Alexis Tremblay, Philippe Laramée, Yoan Lamarche, André Denault, William Beaubien-Souligny, Anne-Julie Frenette, Loay Kontar, Karim Serri and Emmanuel Charbonney

Ultrasonographic assessment of parasternal intercostal muscles during mechanical ventilation

Although mechanical ventilation is a lifesaving treatment, abundant evidence indicates that its prolonged use (1 week or more) promotes respiratory muscle weakness due to both contractile dysfunction and atrop...

Authors: Paolo Formenti, Michele Umbrello, Martin Dres and Davide Chiumello

Bacterial and viral co-infections in patients with severe SARS-CoV-2 pneumonia admitted to a French ICU

Data on the prevalence of bacterial and viral co-infections among patients admitted to the ICU for acute respiratory failure related to SARS-CoV-2 pneumonia are lacking. We aimed to assess the rate of bacteria...

Authors: Damien Contou, Aurore Claudinon, Olivier Pajot, Maïté Micaëlo, Pascale Longuet Flandre, Marie Dubert, Radj Cally, Elsa Logre, Megan Fraissé, Hervé Mentec and Gaëtan Plantefève

Expert consensus-based clinical practice guidelines management of intravascular catheters in the intensive care unit

The French Society of Intensive Care Medicine (SRLF), jointly with the French-Speaking Group of Paediatric Emergency Rooms and Intensive Care Units (GFRUP) and the French-Speaking Association of Paediatric Sur...

Authors: Jean-François Timsit, Julien Baleine, Louis Bernard, Silvia Calvino-Gunther, Michael Darmon, Jean Dellamonica, Eric Desruennes, Marc Leone, Alain Lepape, Olivier Leroy, Jean-Christophe Lucet, Zied Merchaoui, Olivier Mimoz, Benoit Misset, Jean-Jacques Parienti, Jean-Pierre Quenot…

Acute kidney injury in patients with SARS-CoV-2 infection

Acute Kidney Injury (AKI) is a frequent complication of severe SARS-CoV-2 infection. Multiple mechanisms are involved in COVID-19-associated AKI, from direct viral infection and secondary inflammation to compl...

Authors: Adrien Joseph, Lara Zafrani, Asma Mabrouki, Elie Azoulay and Michael Darmon

Epidural analgesia in ICU chest trauma patients with fractured ribs: retrospective study of pain control and intubation requirements

Nonintubated chest trauma patients with fractured ribs admitted to the intensive care unit (ICU) are at risk for complications and may require invasive ventilation at some point. Effective pain control is esse...

Authors: Konstantinos Bachoumas, Albrice Levrat, Aurélie Le Thuaut, Stéphane Rouleau, Samuel Groyer, Hervé Dupont, Paul Rooze, Nathanael Eisenmann, Timothée Trampont, Julien Bohé, Benjamin Rieu, Jean-Charles Chakarian, Aurélie Godard, Laura Frederici, Stephanie Gélinotte, Aurélie Joret…

The impact of critical illness on the expiratory muscles and the diaphragm assessed by ultrasound in mechanical ventilated children

Critical illness has detrimental effects on the diaphragm, but the impact of critical illness on other major muscles of the respiratory pump has been largely neglected. This study aimed to determine the impact...

Authors: Marloes M. IJland, Joris Lemson, Johannes G. van der Hoeven and Leo M. A. Heunks