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  1. Research

    Outcome of in- and out-of-hospital cardiac arrest survivors with liver cirrhosis

    Organ failure increases mortality in patients with liver cirrhosis. Data about resuscitated cardiac arrest patients with liver cirrhosis are missing. This study aims to assess aetiology, survival and functiona...

    Kevin Roedl, Christian Wallmüller, Andreas Drolz, Thomas Horvatits, Karoline Rutter, Alexander Spiel, Julia Ortbauer, Peter Stratil, Pia Hubner, Christoph Weiser, Jasmin Katrin Motaabbed, Dominik Jarczak, Harald Herkner, Fritz Sterz and Valentin Fuhrmann

    Annals of Intensive Care 2017 7:103

    Published on: 6 October 2017

  2. Research

    Ultrasound assessment of rectus femoris and anterior tibialis muscles in young trauma patients

    Quantitative and qualitative changes of skeletal muscle are typical and early findings in trauma patients, being possibly associated with functional impairment. Early assessment of muscle changes—as evaluated ...

    Maria Giuseppina Annetta, Mauro Pittiruti, Davide Silvestri, Domenico Luca Grieco, Alessio Maccaglia, Michele Fabio La Torre, Nicola Magarelli, Giovanna Mercurio, Anselmo Caricato and Massimo Antonelli

    Annals of Intensive Care 2017 7:104

    Published on: 6 October 2017

  3. Research

    Prognostic implications of blood lactate concentrations after cardiac arrest: a retrospective study

    Elevated lactate concentration has been associated with increased mortality after out-of-hospital cardiac arrest (CA). We investigated the variables associated with high blood lactate concentrations and explor...

    Antonio Maria Dell’Anna, Claudio Sandroni, Irene Lamanna, Ilaria Belloni, Katia Donadello, Jacques Creteur, Jean-Louis Vincent and Fabio Silvio Taccone

    Annals of Intensive Care 2017 7:101

    Published on: 6 October 2017

  4. Research

    Endothelial glycocalyx degradation is more severe in patients with non-pulmonary sepsis compared to pulmonary sepsis and associates with risk of ARDS and other organ dysfunction

    Disruption of the endothelial glycocalyx contributes to acute lung injury in experimental sepsis but has not been well studied in humans. To study glycocalyx degradation in sepsis-induced ARDS, we measured pla...

    Laura S. Murphy, Nancy Wickersham, J. Brennan McNeil, Ciara M. Shaver, Addison K. May, Julie A. Bastarache and Lorraine B. Ware

    Annals of Intensive Care 2017 7:102

    Published on: 6 October 2017

  5. Research

    The association between FABP7 serum levels with survival and neurological complications in acetaminophen-induced acute liver failure: a nested case–control study

    Acetaminophen (APAP)-induced acute liver failure (ALF) is associated with significant mortality due to intracranial hypertension (ICH), a result of cerebral edema (CE) and astrocyte swelling. Brain-type fatty ...

    Constantine J. Karvellas, Jaime L. Speiser, Mélanie Tremblay, William M. Lee and Christopher F. Rose

    Annals of Intensive Care 2017 7:99

    Published on: 5 October 2017

  6. Research

    Interstitial pneumonia with autoimmune features: an additional risk factor for ARDS?

    Interstitial pneumonia with autoimmune features (IPAF) identifies a recently recognized autoimmune syndrome characterized by interstitial lung disease and autoantibodies positivity, but absence of a specific c...

    Giacomo Grasselli, Beatrice Vergnano, Maria Rosa Pozzi, Vittoria Sala, Gabriele D’Andrea, Vittorio Scaravilli, Marco Mantero, Alberto Pesci and Antonio Pesenti

    Annals of Intensive Care 2017 7:98

    Published on: 18 September 2017

  7. Research

    Derivation and validation of a prognostic model for postoperative risk stratification of critically ill patients with faecal peritonitis

    Prognostic scores and models of illness severity are useful both clinically and for research. The aim of this study was to develop two prognostic models for the prediction of long-term (6 months) and 28-day m...

    Ascanio Tridente, Julian Bion, Gary H. Mills, Anthony C. Gordon, Geraldine. M. Clarke, Andrew Walden, Paula Hutton, Paul A. H. Holloway, Jean-Daniel Chiche, Frank Stuber, Christopher Garrard and Charles Hinds

    Annals of Intensive Care 2017 7:96

    Published on: 12 September 2017

  8. Research

    High level of venous thromboembolism in critically ill trauma patients despite early and well-driven thromboprophylaxis protocol

    Venous thromboembolism (VTE) is one of the most common preventable causes of in-hospital death in trauma patients surviving their injuries. We assessed the prevalence, incidence and risk factors for deep venou...

    S. R. Hamada, C. Espina, T. Guedj, R. Buaron, A. Harrois, S. Figueiredo and J. Duranteau

    Annals of Intensive Care 2017 7:97

    Published on: 12 September 2017

  9. Research

    Short-term effects of passive mobilization on the sublingual microcirculation and on the systemic circulation in patients with septic shock

    Active mobilization is not possible in patients under deep sedation and unable to follow commands. In this scenario, passive therapy is an interesting alternative. However, in patients with septic shock, passi...

    Tuanny Teixeira Pinheiro, Flávio Geraldo Rezende de Freitas, Karla Tuanny Fiorese Coimbra, Vanessa Marques Ferreira Mendez, Heloísa Baccaro Rossetti, Paulo Vinicius Talma, Antônio Tonete Bafi and Flávia Ribeiro Machado

    Annals of Intensive Care 2017 7:95

    Published on: 8 September 2017

  10. Research

    Prognostic impact of isolated right ventricular dysfunction in sepsis and septic shock: an 8-year historical cohort study

    Echocardiographic myocardial dysfunction is reported commonly in sepsis and septic shock, but there are limited data on sepsis-related right ventricular dysfunction. This study sought to evaluate the associati...

    Saraschandra Vallabhajosyula, Mukesh Kumar, Govind Pandompatam, Ankit Sakhuja, Rahul Kashyap, Kianoush Kashani, Ognjen Gajic, Jeffrey B. Geske and Jacob C. Jentzer

    Annals of Intensive Care 2017 7:94

    Published on: 7 September 2017

  11. Research

    Cell-cycle arrest biomarkers in urine to predict acute kidney injury in septic and non-septic critically ill patients

    To analyse the usefulness of the composite index of the tissue inhibitor of metalloproteinases-2 (TIMP-2) and insulin-like growth factor-binding protein 7 (IGFBP7) as urinary biomarkers for the early predictio...

    M. Cuartero, J. Ballús, J. Sabater, X. Pérez, N. Nin, J. Ordonez-Llanos and A. J. Betbesé

    Annals of Intensive Care 2017 7:92

    Published on: 7 September 2017

  12. Research

    Endocan as an early biomarker of severity in patients with acute respiratory distress syndrome

    Plasma concentrations of endocan, a proteoglycan preferentially expressed in the pulmonary vasculature, may represent a biomarker of lung (dys)function. We sought to determine whether the measurement of plasma...

    Diego Orbegozo, Lokmane Rahmania, Marian Irazabal, Manuel Mendoza, Filippo Annoni, Daniel De Backer, Jacques Creteur and Jean-Louis Vincent

    Annals of Intensive Care 2017 7:93

    Published on: 7 September 2017

  13. Research

    Comparison of diagnostic accuracy in sepsis between presepsin, procalcitonin, and C-reactive protein: a systematic review and meta-analysis

    The soluble cluster of differentiation 14 (or presepsin) is a free fragment of glycoprotein expressed on monocytes and macrophages. Although many studies have been conducted recently, the diagnostic performan...

    Chin-Chieh Wu, Hao-Min Lan, Shih-Tsung Han, Chung-Hsien Chaou, Chun-Fu Yeh, Su-Hsun Liu, Chih-Huang Li, Gerald N. Blaney III, Zhen-Ying Liu and Kuan-Fu Chen

    Annals of Intensive Care 2017 7:91

    Published on: 6 September 2017

  14. Research

    Astragaloside-IV prevents acute kidney injury and inflammation by normalizing muscular mitochondrial function associated with a nitric oxide protective mechanism in crush syndrome rats

    Crush syndrome (CS) is a serious medical condition characterized by muscle cell damage resulting from decompression after compression (i.e., ischemia/reperfusion injury). A large number of CS patients develop ...

    Isamu Murata, Yuji Abe, Yuka Yaginuma, Kayako Yodo, Yuka Kamakari, Yurika Miyazaki, Daichi Baba, Yuko Shinoda, Toru Iwasaki, Kunihiko Takahashi, Jun Kobayashi, Yutaka Inoue and Ikuo Kanamoto

    Annals of Intensive Care 2017 7:90

    Published on: 4 September 2017

  15. Research

    Hemofiltration induces generation of leukocyte-derived CD31+/CD41− microvesicles in sepsis

    Microvesicles (MV) are extracellular vesicles known to be associated with cellular activation and inflammation. Hemofiltration is an effective blood purification technique for patients with renal failure and p...

    Georg Franz Lehner, Ulrich Harler, Clemens Feistritzer, Viktoria Maria Haller, Julia Hasslacher, Romuald Bellmann and Michael Joannidis

    Annals of Intensive Care 2017 7:89

    Published on: 4 September 2017

  16. Research

    Opioid-associated iatrogenic withdrawal in critically ill adult patients: a multicenter prospective observational study

    Opioids and benzodiazepines are frequently used in the intensive care unit (ICU). Regular use and prolonged exposure to opioids in ICU patients followed by abrupt tapering or cessation may lead to iatrogenic w...

    Pan Pan Wang, Elaine Huang, Xue Feng, Charles-André Bray, Marc M. Perreault, Philippe Rico, Patrick Bellemare, Paul Murgoi, Céline Gélinas, Annie Lecavalier, Dev Jayaraman, Anne Julie Frenette and David Williamson

    Annals of Intensive Care 2017 7:88

    Published on: 2 September 2017

  17. Research

    Prognostic indicators of survival and survival prediction model following extracorporeal cardiopulmonary resuscitation in patients with sudden refractory cardiac arrest

    Extracorporeal cardiopulmonary resuscitation (ECPR) has been considered in selected candidates with potentially reversible causes during a limited period. Candidate selection and the identification of predicta...

    Sung Woo Lee, Kap Su Han, Jong Su Park, Ji Sung Lee and Su Jin Kim

    Annals of Intensive Care 2017 7:87

    Published on: 30 August 2017

  18. Research

    Validation of transpulmonary thermodilution variables in hemodynamically stable patients with heart diseases

    Transpulmonary thermodilution is recommended in the treatment of critically ill patients presenting with complex shock. However, so far it has not been validated in hemodynamically stable patients with heart d...

    Matthias Peter Hilty, Daniel Peter Franzen, Christophe Wyss, Patric Biaggi and Marco Maggiorini

    Annals of Intensive Care 2017 7:86

    Published on: 22 August 2017

  19. Research

    Lymphopaenia in cardiac arrest patients

    A decrease in circulating lymphocytes has been described as a marker of poor prognosis after septic shock; however, scarce data are available after cardiac arrest (CA). The aim of this study was to evaluate th...

    Paola Villois, David Grimaldi, Savino Spadaro, Claudia Righy Shinotsuka, Vito Fontana, Sabino Scolletta, Federico Franchi, Jean-Louis Vincent, Jacques Creteur and Fabio Silvio Taccone

    Annals of Intensive Care 2017 7:85

    Published on: 14 August 2017

  20. Research

    Efficacy and safety of argatroban in patients with acute respiratory distress syndrome and extracorporeal lung support

    Extracorporeal membrane oxygenation (ECMO) or pumpless extracorporeal lung assist (pECLA) requires effective anticoagulation. Knowledge on the use of argatroban in patients with acute respiratory distress synd...

    Mario Menk, Philipp Briem, Björn Weiss, Martina Gassner, David Schwaiberger, Anton Goldmann, Christian Pille and Steffen Weber-Carstens

    Annals of Intensive Care 2017 7:82

    Published on: 3 August 2017

  21. Research

    How to reduce cisatracurium consumption in ARDS patients: the TOF-ARDS study

    Neuromuscular blocking agents (NMBAs) have been shown to improve the outcome of the most severely hypoxemic, acute respiratory distress syndrome (ARDS) patients. However, the recommended dosage as well as the ...

    Sami Hraiech, Jean-Marie Forel, Christophe Guervilly, Romain Rambaud, Samuel Lehingue, Mélanie Adda, Pierre Sylla, Sabine Valera, Julien Carvelli, Marc Gainnier, Laurent Papazian and Jérémy Bourenne

    Annals of Intensive Care 2017 7:79

    Published on: 2 August 2017

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