Annals of Intensive Care

Few specific medications have been proven effective for the treatment of patients with severe coronavirus disease 2019 (COVID-19). Here, Zhang et al. tested whether high-dose vitamin C infusion was effective for severe COVID-19.

This is a bicenter retrospective study which took place in two intensive care units (ICU) of tertiary hospitals in the Paris region from March 11, to May 3, 2020. According to results, high flow nasal canula oxygen for acute respiratory failure (ARF) due to COVID-19 is associated with a lower rate of invasive mechanical ventilation.

Severe COVID-19 pediatric cases are less frequent than the adults ones, nevertheless acute myocarditis with intense systemic inflammation and atypical Kawasaki disease  was reported as an emerging severe pediatric disease following SARS-CoV-2 infection. M. Grimaud et al. here provide the first characterization and assessment of this upcoming clinical post-infective complications of SARS-CoV-2 infection.

Early recognition and intervention is crucial in the struggle against COVID-19 pandemics.
Quin Sun et al.  retrospectively summarize the therapeutic process and figure out critical care-dominated treatment patterns that might be the core in reducing mortality.