Annals of Intensive Care

Early recognition and intervention is crucial in the struggle against COVID-19 pandemics.
Quin Sun et al.  retrospectively summarize the therapeutic process and figure out critical care-dominated treatment patterns that might be the core in reducing mortality.

This is a bicenter retrospective study which took place in two intensive care units (ICU) of tertiary hospitals in the Paris region from March 11, to May 3, 2020. According to results, high flow nasal canula oxygen for acute respiratory failure (ARF) due to COVID-19 is associated with a lower rate of invasive mechanical ventilation.

Acute myocarditis with intense systemic inflammation and atypical Kawasaki disease was reported as an emerging severe pediatric disease following SARS-CoV-2 infection. M. Grimaud et al. provide the first characterization and assessment of this complication of SARS-CoV-2 infection.

Few specific medications have been proven effective for the treatment of patients with severe coronavirus disease 2019 (COVID-19). Here, Zhang et al. tested whether high-dose vitamin C infusion was effective for severe COVID-19. This randomized, controlled, clinical trial was performed at 3 hospitals in Hubei, China.

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