Table 2 Trials without significant difference between antibiotic monotherapy and combination therapy for CAP
From: Combination antibiotic therapy for community-acquired pneumonia
Author | Year | Cohort | Outcome | Study design |
|---|---|---|---|---|
Burgess and Lewiss [30] | 2000 | Hospitalized CAP without identified microorganism | Nonstatistical differences third-generation cephalosporin ± macrolide | Bicenter, retrospective |
Dwyer et al. [31] | 2006 | Bacteremic pneumococcal CAP | No significant difference in case fatality if initial β-lactam + macrolide | Multicenter, retrospective |
Harbarth et al. [32] | 2005 | Pneumococcal sepsis | Lack of effect of combo therapy | Multicenter, retrospective |
Leroy et al. [33] | 2005 | CAP without vasopressors | Levofloxacin vs. cefotaxime + ofloxacin | Multicenter, retrospective |