Urea for treatment of acute SIADH in patients with subarachnoid hemorrhage: a single-center experience

Annals of Intensive Care

Table 3 Sodium and volume balance before (day −2 and day −1) and after (day 1 and day 2) the onset of urea therapy

Variable	Day −2	Day −1	Day 1	Day 2	After urea
Fluid intake (mL/24 hr)	4411 ± 1149	3958 ± 1348	3784 ± 1090	3875 ± 1370	2567 ± 1370
Urine output (mL/24 hr)	3886 ± 1842	3757 ± 1174	4288 ± 1472	4296 ± 1692^a	1879 ± 489
Na intake (mEq/24 hr)	349 ± 181	375 ± 171	350 ± 161	346 ± 193	141 ± 69
Urine Na (mEq/24 hr)	520 ± 244	521 ± 262	467 ± 256^a,b	491 ± 355	78 ± 36
Urine osmolality (mOsm/Kg)	515 ± 164	498 ± 125	578 ± 119	611 ± 134^b	418 ± 96
Serum urea (mg/dL)	30 ± 9	30 ± 6	39 ± 11^a,b	37 ± 10^a,b	31 ± 6
Urine urea (mg/dL)	632 ± 319	699 ± 418	1653 ± 677^a,b	1894 ± 455^a,b	788 ± 401

“After urea” shows data on the fifth day after urea discontinuation (n = 34). Data are presented as mean ± SD. ANOVA analysis for urine output: p = 0.048. ANOVA analysis for urin osmolality: p = 0.005. ANOVA analysis for urine Na: p = 0.04. ANOVA analysis for serum urea: p < 0.001. P value < 0.05 vs. day −2 (^a), day −1 (^b), or day 1 (^c) in post-hoc Bonferroni correction.