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Table 3 Sodium and volume balance before (day −2 and day −1) and after (day 1 and day 2) the onset of urea therapy

From: Urea for treatment of acute SIADH in patients with subarachnoid hemorrhage: a single-center experience

Variable Day −2 Day −1 Day 1 Day 2 After urea
Fluid intake (mL/24 hr) 4411 ± 1149 3958 ± 1348 3784 ± 1090 3875 ± 1370 2567 ± 1370
Urine output (mL/24 hr) 3886 ± 1842 3757 ± 1174 4288 ± 1472 4296 ± 1692a 1879 ± 489
Na intake (mEq/24 hr) 349 ± 181 375 ± 171 350 ± 161 346 ± 193 141 ± 69
Urine Na (mEq/24 hr) 520 ± 244 521 ± 262 467 ± 256a,b 491 ± 355 78 ± 36
Urine osmolality (mOsm/Kg) 515 ± 164 498 ± 125 578 ± 119 611 ± 134b 418 ± 96
Serum urea (mg/dL) 30 ± 9 30 ± 6 39 ± 11a,b 37 ± 10a,b 31 ± 6
Urine urea (mg/dL) 632 ± 319 699 ± 418 1653 ± 677a,b 1894 ± 455a,b 788 ± 401
  1. “After urea” shows data on the fifth day after urea discontinuation (n = 34). Data are presented as mean ± SD. ANOVA analysis for urine output: p = 0.048. ANOVA analysis for urin osmolality: p = 0.005. ANOVA analysis for urine Na: p = 0.04. ANOVA analysis for serum urea: p < 0.001. P value < 0.05 vs. day −2 (a), day −1 (b), or day 1 (c) in post-hoc Bonferroni correction.