Antibiotic | Mean Css (mg/L) | Enterobacteriaceae | Pseudomonas aeruginosa | ||||
---|---|---|---|---|---|---|---|
 |  | EUCAST | CLSI | EUCAST and CLSI | |||
 |  | Breakpoint | Ratio: Css/highest possible MIC within susceptibility range | Breakpoint | Ratio: Css/highest possible MIC within susceptibility range | Breakpoint | Ratio: Css/highest possible MIC within susceptibility range |
Ceftazidime [25]6 g/24 h | 75 | ≤1 | 75 | ≤4 | 18.75 | ≤8 | 9.37 |
Ceftazidime [26]4.5 g/24 h | 47 | ≤1 | 47 | ≤4 | 11.75 | ≤8 | 5.87 |
Ceftazidime [27]3 g/24 h | 30 | ≤1 | 30 | ≤4 | 7.5 | ≤8 | 3.75 |
Ceftazidime [28]60 mg/kg/d | 19 | ≤1 | 19 | ≤4 | 4.75 | ≤8 | 2.37 |
Ceftazidime [29]4 g/24 h | 40 | ≤1 | 40 | ≤4 | 10 | ≤8 | 5 |
Ceftazidime [11]6 g/24 h | 63 | ≤1 | 63 | ≤4 | 15.75 | ≤8 | 7.87 |
Cefepime [30]4 g/24 h | 41 | ≤1 | 41 | ≤8 | 5.13 | ≤8 | 5.13 |
Cefepime [31]4 g/24 h | 13.5 | ≤1 | 13.5 | ≤8 | 1.68 | ≤8 | 1.68 |
Piperacillin [32]13.5 g/24 h | 35 | ≤8 | 4.37 | ≤16 | 2.18 | ≤16 | 2.18 |
Piperacillin [33]12 g/24 h | 18 | ≤8 | 2.25 | ≤16 | 1.125 | ≤16 | 1.125 |
Meropenem [15]3 g/24 h | 7 | ≤2 | 3.5 | ≤1 | 7 | ≤2 | 3.5 |