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Table 1 Overview of studies investigating PK-parameters of continuous infusion of different antimicrobials in critically ill patients

From: Continuous infusion of antibiotics in the critically ill: The new holy grail for beta-lactams and vancomycin?

Antibiotic Mean Css (mg/L) Enterobacteriaceae Pseudomonas aeruginosa
   EUCAST CLSI EUCAST and CLSI
   Breakpoint Ratio: Css/highest possible MIC within susceptibility range Breakpoint Ratio: Css/highest possible MIC within susceptibility range Breakpoint Ratio: Css/highest possible MIC within susceptibility range
Ceftazidime [25]6 g/24 h 75 ≤1 75 ≤4 18.75 ≤8 9.37
Ceftazidime [26]4.5 g/24 h 47 ≤1 47 ≤4 11.75 ≤8 5.87
Ceftazidime [27]3 g/24 h 30 ≤1 30 ≤4 7.5 ≤8 3.75
Ceftazidime [28]60 mg/kg/d 19 ≤1 19 ≤4 4.75 ≤8 2.37
Ceftazidime [29]4 g/24 h 40 ≤1 40 ≤4 10 ≤8 5
Ceftazidime [11]6 g/24 h 63 ≤1 63 ≤4 15.75 ≤8 7.87
Cefepime [30]4 g/24 h 41 ≤1 41 ≤8 5.13 ≤8 5.13
Cefepime [31]4 g/24 h 13.5 ≤1 13.5 ≤8 1.68 ≤8 1.68
Piperacillin [32]13.5 g/24 h 35 ≤8 4.37 ≤16 2.18 ≤16 2.18
Piperacillin [33]12 g/24 h 18 ≤8 2.25 ≤16 1.125 ≤16 1.125
Meropenem [15]3 g/24 h 7 ≤2 3.5 ≤1 7 ≤2 3.5
  1. EUCAST = European Committee on Antimicrobial Susceptibility Testing; CLSI = Clinical and Laboratory Standards Institute; Css = steady state concentration; MIC = minimal inhibitory concentration.