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Table 5 List of drugs that are incompatible with different time-dependent antibiotics when given trough the same intravenous line (Y-site incompatibilities)

From: Continuous infusion of antibiotics in the critically ill: The new holy grail for beta-lactams and vancomycin?

Time-dependent antibiotic Incompatible drugs (should not be given trough the same intravenous line)
Flucloxacillin [64] Clarithromycin, lorazepam, midazolam, vancomycin
Ceftazidime [61, 64] Acetylcysteine, nicardipine, midazolam, propofol, and vancomycin
Cefepime [62, 64] Erythromycin, propofol, midazolam, phenytoin, piritramide, theophylline, nicardipine, N-acetylcysteine, vancomycin, and a concentrated solution of dobutamine
Piperacillin-tazobactam [64] Acyclovir, amiodarone, amphotericin B cholesteryl sulfate complex, azithromycin, dobutamine, ganciclovir, haloperidol, vancomycin
Meropenem [64] Acyclovir, amphotericin B, diazepam, ondansetron, doxycycline
Imipenem [64] Allopurinol, amiodarone, amphotericin B cholesteryl sulfate complex, azithromycin, fluconazole, lorazepam, midazolam,
Temocillin [13] Other beta-lactam antibiotics, vancomycin, ciprofloxacin, clindamycin, propofol, midazolam, nicardipine, ranitidine, vitamin K
Vancomycin [unpublished data by Ampe E, article in preparation] Flucloxacillin, temocillin, piperacillin-tazobactam, cephalosporins, imipenem, moxifloxacin, propofol, valproate, phenytoin, theophylline, furosemide, methylprednisolone