Table 5 List of drugs that are incompatible with different time-dependent antibiotics when given trough the same intravenous line (Y-site incompatibilities)
Time-dependent antibiotic | Incompatible drugs (should not be given trough the same intravenous line) |
|---|---|
Flucloxacillin [64] | Clarithromycin, lorazepam, midazolam, vancomycin |
Acetylcysteine, nicardipine, midazolam, propofol, and vancomycin | |
Erythromycin, propofol, midazolam, phenytoin, piritramide, theophylline, nicardipine, N-acetylcysteine, vancomycin, and a concentrated solution of dobutamine | |
Piperacillin-tazobactam [64] | Acyclovir, amiodarone, amphotericin B cholesteryl sulfate complex, azithromycin, dobutamine, ganciclovir, haloperidol, vancomycin |
Meropenem [64] | Acyclovir, amphotericin B, diazepam, ondansetron, doxycycline |
Imipenem [64] | Allopurinol, amiodarone, amphotericin B cholesteryl sulfate complex, azithromycin, fluconazole, lorazepam, midazolam, |
Temocillin [13] | Other beta-lactam antibiotics, vancomycin, ciprofloxacin, clindamycin, propofol, midazolam, nicardipine, ranitidine, vitamin K |
Vancomycin [unpublished data by Ampe E, article in preparation] | Flucloxacillin, temocillin, piperacillin-tazobactam, cephalosporins, imipenem, moxifloxacin, propofol, valproate, phenytoin, theophylline, furosemide, methylprednisolone |