Table 2 Demographic and baseline clinical characteristics of HIV-infected patients admitted to the ICU, stratified according to immunovirological statuses
Patients with complete immunovirological status available | ||||||
|---|---|---|---|---|---|---|
Total | n = 76 | |||||
CD4 high | CD4 low | CD4 low | CD4 high | p value | ||
n = 98 | VL high | VL high | VL low | VL low | ||
Variable (n,%) | n = 14 | n = 40 | n = 10 | n = 12 | ||
Males | 69 (70.4) | 8 (57.1) | 28 (70) | 8 (80) | 10 (83.3) | 0.496 |
Age, yr (mean ± SD) | 43.1 (10.7) | 42.2 (8.5) | 40.1 (8.7) | 46.8 (16.7) | 54.7 (10.5) | <0.001 |
Time since HIV diagnosis | ||||||
Less than 6 months | 17 (17.3) | 1 (7.1) | 8 (20) | 1 (10) | 0 (0) | |
Intermediate | 14 (14.3) | 4 (28.6) | 6 (15) | 2 (20) | 2 (16.7) | 0.62 |
More than 5 years | 67 (68.4) | 9 (64.3) | 26 (65) | 7 (70) | 10 (83.3) | |
HIV diagnosis in ICU | 8 (8.2) | 0 (0) | 6 (15) | 0 (0) | 0 (0) | 0.217 |
Comorbidities | ||||||
HbsAg-positive. | 14 (14.3) | 3 (21.4) | 6 (15) | 0 (0) | 1 (8.3) | 0.532 |
Anti-hepatitis C virus positive | 30 (30.6) | 10 (71.4) | 7 (17.5) | 4 (40) | 2 (16.7) | 0.001 |
HbsAg + antihepatitis C virus positive | 7 (7.1) | 3 (21.4) | 2 (5) | 0 (0) | 0 (0) | 0.117 |
Alcohol abuse | 29 (30) | 8 (57.1) | 13 (32.5) | 2 (20) | 2 (16.7) | 0.137 |
Tobacco | 30 (31) | 8 (57.1) | 15 (37.5) | 1 (10) | 3 (25) | 0.099 |
Past medical history of cancer | 13 (12.6) | 0 (0) | 3 (7.5) | 4 (40) | 2 (16.7) | 0.016 |
Main reasons for ICU admission | ||||||
Acute respiratory failure | 38 (38.8) | 8 (57.1) | 16 (40) | 2 (20) | 3 (25) | |
Sepsis | 11 (11.2) | 1 (7.1) | 3 (7.5) | 1 (10) | 2 (16.7) | 0.749 |
Severe neurologic disorders | 25 (25.5) | 2 (14.3) | 11 (27.5) | 4 (40) | 3 (25) | |
Miscellaneous | 24 (24.5) | 3 (21.5) | 10 (25) | 3 (30) | 6 (33.3) | |
Opportunistic infections | ||||||
No opportunistic infection | 73 | 14 (100) | 25 (62.5) | 10 (100) | 11 (91.7) | 0.002 |
Pneumocystis jirovecii pneumonia | 11 (11.2) | 0 (0) | 5 (12.5) | 0 (0) | 1 (8.3) | |
Tuberculosis | 1 (1) | 0 (0) | 1 (1) | 0 (0) | 0 (0) | - |
Toxoplasmosis | 6 (6.1) | 0 (0) | 4 (10) | 0 (0) | 0 (0) | |
Cryptococcosis | 3 (3) | 0 (0) | 2 (5) | 0 (0) | 0 (0) | |
Reactivation of cytomegalovirus (antigenemia positive) | 15 (15.3) | 0 (0) | 10 (25) | 0 (0) | 1 (8.3) | 0.054 |
ICU data | ||||||
SAPS II score (median) | 49.5 | 52 | 48.5 | 56 | 49.5 | 0.522 |
APACHE II score (median) | 17.5 | 16.5 | 18 | 20 | 14.5 | 0.509 |
Albumin, g/dL (median) | 26.1 | 32.1 | 28.8 | 30.7 | 42.1 | 0.169 |
Mechanical ventilation in the first day | 59 (60.2) | 10 (71.4) | 19 (47.5) | 8 (80) | 8 (66.7) | 0.176 |