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Table 3 Characteristics of drugs traditionally considered to require TDM [92, 93]

From: Does Beta-lactam Pharmacokinetic Variability in Critically Ill Patients Justify Therapeutic Drug Monitoring? A Systematic Review

No. Criteria
1 Narrow therapeutic range/index
2 Drug toxicity may lead to hospitalization, irreversible organ damage, and even death
3 No clearly defined clinical parameter that allows dose adjustments
4 Correlation exists between serum concentration and efficacy as well as toxicity
5 Unpredictable relationship between dose and clinical outcome
6 Difficult to predict pharmacokinetics (e.g. non-linear pharmacokinetics)