Table 3 Characteristics of drugs traditionally considered to require TDM [92, 93]
No. | Criteria |
|---|---|
1 | Narrow therapeutic range/index |
2 | Drug toxicity may lead to hospitalization, irreversible organ damage, and even death |
3 | No clearly defined clinical parameter that allows dose adjustments |
4 | Correlation exists between serum concentration and efficacy as well as toxicity |
5 | Unpredictable relationship between dose and clinical outcome |
6 | Difficult to predict pharmacokinetics (e.g. non-linear pharmacokinetics) |