Relationship of systemic, hepatosplanchnic, and microcirculatory perfusion parameters with 6-hour lactate clearance in hyperdynamic septic shock patients: an acute, clinical-physiological, pilot study

Annals of Intensive Care

Table 1 Baseline characteristics of 15 hyperdynamic septic shock patients according to a 6-hour lactate clearance higher or lower than 10%

Pt.	Age	Survival	Sepsis source	SOFA	APACHE II	MAP	MAP	∆PP	∆PP	NE	NE	IAP	IAP	LactateBasal	LactateEnd	CO ₂GapBasal	CO ₂GapEnd	PDRBasal	PDR	MFI	MFI
						*Basal*	*End*	*Basal*	*End*	*Basal*	*End*	*Basal*	*End*						*End*	*Basal*	*End*
	Lactate clearance >10%
1	26	No	Peritonitis	10	24	66	68	6	8	0.11	0.05	9	9	2.4	1.6	-	-	24.6	32	2.8	2.3
2	66	Yes	Unknown	9	24	76	68	2	2	0.21	0.17	11	10	3.4	2.8	6.1	7.1	28.2	27.8	2.5	2.9
3	83	Yes	Respiratory	10	19	78	77	0	0	0.1	0.05	13	11	4.5	1.5	2.1	58.7	13.3	18.1	1.4	1.8
4	56	Yes	Peritonitis	9	25	82	67	8	29	0.09	0.12	18	21	3	2	5.3	4.6	19.9	17.7	2.3	1.8
5	83	No	Peritonitis	8	23	72	65	5	5	0.26	0.45	4	8	19	16.2	0	0.1	-	-	2.2	1.9
6	97	Yes	Peritonitis	8	25	86	68	10	17	0.25	0.14	9	20	2.5	1.8	8.3	16.7	28	31.1	2.5	2
7	66	Yes	Peritonitis	8	23	66	68	6	8	0.43	0.7	16	9	3.1	2.5	4.7	2.3	20.8	19.6	1.4	1.9
8	67	Yes	Peritonitis	13	20	75	70	8	7	0.21	0.23	14	15	4.9	3.3	6.2	9.3	19	23.3	2.2	2.3
9	69	Yes	Skin	13	16	72	71	10	16	0.25	0.34	6	13	3.5	2.9	10.7	7.7	11.7	9	1.3	2.5
10	71	Yes	Peritonitis	15	42	73	75	8	6	0.3	0.46	10	11	6.2	5.4	5	18.1	-	-	1.2	1.3
	Lactate clearance <10%
11	76	Yes	Unknown	13	36	72	72	5	2	0.08	0.08	11	15	2.8	2.7	5.9	9.1	14.4	9.7	1.9	2.1
12	58	Yes	Skin	19	38	64	64	4	2	0.4	0.65	18	18	4.9	5.6	23.9	52.5	19.5	8.1	2.2	2.9
13	73	Yes	Peritonitis	7	25	110	69	3,4	2	0.1	0.06	12	13	4.2	3.8	8.1	12	19	19	1.5	1.5
14	67	Yes	Peritonitis	15	29	69	70	0	0	0.03	0.05	7	8	2.5	2.5	61.6	62.9	9.8	11.3	1.0	1.8
15	56	Yes	Respiratory	8	19	73	92	9	5	0.1	0.08	9	6	2.8	3.2	10.8	33	8.4	7.8	1.9	1.9

Pt, patient; Survival, hospital survival; APACHE II, Acute Physiology and Chronic Health Evaluation II; IAP, intra-abdominal pressure (mmHg); SOFA, Sequential Organ Failure Assessment; MAP, mean arterial pressure (mmHg), ∆PP, Pulse pressure variation (%), NE, norepinephrine requirements (mcg/kg/min); lactate, (mmol/l); MFI, microcirculatory flow index; CO₂ gap, gastric/arterial pCO₂ gradient (mmHg); PDR, indocyanine green plasma disappearance rate (%min).