Table 2 Mean absolute change of selected variables after 1 week

SOFA score

   Respiratory

0.0 ± 1.7

-0.8 ± 1.6

0.015

   Coagulation

0.4 ± 1.1

0.1 ± 0.9

0.181

   Liver

0.3 ± 1.1

0.4 ± 0.8

0.553

   Cardiovascular

-0.5 ± 1.9

-1.2 ± 2.0

0.087

   Nervous

0.2 ± 2.0

-0.2 ± 1.8

0.271

   Renal

0.2 ± 1.8

0.3 ± 1.5

0.693

   Total

0.7 ± 5.4

-1.3 ± 5.0

0.057

Number of organs failing

-0.1 ± 1.6

-0.6 ± 1.5

0.115

Hemodynamic variables

   HR (bpm)

-11.5 ± 16.3

11.1 ± 95.2

0.183

   Mean arterial pressure (mmHg)

4.1 ± 13.6

0.6 ± 15.5

0.247

   CI (L/min/m²)

0.9 ± 0.2

1.0 ± 0.2

0.274

Respiratory variables

   Plateau pressure (cmH₂O)

2.2 ± 8.6

0.7 ± 8.9

0.431

   PEEP (cmH₂O)

2.1 ± 3.6

0.5 ± 3.8

0.050

   Dynamic compliance (mL/cmH₂O)

1.6 ± 24.3

5.3 ± 31.4

0.548

   PaO₂/FIO₂ ratio

-12.3 ± 166.4

99.9 ± 110.5

< 0.001

EVLWI (mL/kg)

-1.1 ± 3.7

-4.2 ± 5.6

0.006

Albumin (g/L)

1.1 ± 9.0

6.3 ± 8.9

0.008

Creatinine (mg/dL)

-0.5 ± 2.0

-0.1 ± 1.1

0.171

Capillary leak index

-17.1 ± 75.5

-31.0 ± 47.4

0.111

Intra-abdominal pressure (mmHg)

1.8 ± 3.8

-0.4 ± 3.6

0.007

Abdominal perfusion pressure (mmHg)

0.4 ± 14.4

1.3 ± 15.5

0.785

Cumulative fluid balance (mL/day)

8,027 ± 5,254

-1,451 ± 7,761

< 0.001