Cotrimoxazole - optimal dosing in the critically ill

Annals of Intensive Care

Table 3 Selected cotrimoxazole (TMP/SMX) toxicities and relationship to drug concentration

Idiosyncratic toxicity	Concentration dependent toxicity
Allergic skin reaction [31]	Apraxia [32]
Cholestasis [33]	Delirium [34]
Hemolytic crisis [35]	Hyperkalemia [36]
Hepatitis [37]	Hypoglycemia [38]
Interstitial nephritis [39]	Aseptic meningitis [40]
Methemoglobinemia [41]	Metabolic acidosis [42]
MODS [43]	Myoclonus [44]
Pancreatitis [45]	Psychosis [46]
Parotitis [47]	Renal tubular obstruction [48]
Stevens-Johnson syndrome [49]	Tremor [50]
Thrombocytopenia [51]
Torsades de pointe [52]

MODS, Multi-organ dysfunction syndrome. Square-bracketed numbers indicate references.