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Table 1 Baseline characteristics of patients from the sepsis cohort

From: Vitamin D deficiency and risk of acute lung injury in severe sepsis and severe trauma: a case-control study

Characteristic

N

Cases

Controls

Combined

P-value

  

(n = 120)

(n = 120)

(n = 240)

 

Agec (IQR)

240

59.3 (53.2, 65.7)

59.3 (52.7, 65.7)

59.3 (53.2, 65.7)

0.885a

Female gender (%)

240

53 (44)

56 (47)

109 (45)

0.791b

Smoking (%)

231

   

0.505b

Never

 

40 (34)

33 (29)

73 (32)

 

Former

 

44 (38)

40 (35)

84 (36)

 

Current

 

33 (28)

41 (36)

74 (32)

 

Diabetes (%)

240

31 (26)

47 (39)

78 (32)

0.045b

Summer season (%)

240

34 (28)

35 (29)

69 (29)

1b

Day length hours (IQR)c

240

12.0 (10.6, 13.6)

12.0 (10.6, 13.5)

12.0 (10.6, 13.6)

0.655a

APACHE II Score (IQR)c

240

28 (23, 32.2)

28 (23, 32.2)

28 (23, 32.2)

NA

Number of non-pulmonary organ failures (%)

240

   

0.753a

0

 

15 (12)

24 (20)

39 (16)

 

1

 

60 (50)

45 (38)

105 (44)

 

2

 

39 (32)

39 (32)

78 (32)

 

3

 

4 (3)

9 (8)

13 (5)

 

4

 

2 (2)

3 (2)

5 (2)

 

Days of ICU stay (IQR)

240

9 (6,15)

6 (4,10)

7 (4,14)

0.008a

Hospital mortality (%)

240

30 (25)

31 (26)

61 (25)

1b

One-year mortality (%)

240

66 (55)

71 (59)

137 (57)

0.614b

Risk factors for ALI/ARDS

240

   

< 0.001b

Non-pulmonary sepsis

 

55 (46)

70 (60)

125 (53)

 

Pneumonia

 

39 (33)

22 (19)

61 (26)

 

Aspiration

 

24 (20)

8 (7)

32 (14)

 

Other or Noned

 

1 (1)

16 (14)

17 (16)

 

Patients on ventilator

 

89 (74)

71 (59)

160 (67)

0.016b

25-OHD (nmol/L) (IQR)

239

45.8 (29.9, 60.8)

39.0 (25.0, 56.9)

43.2 (27.6, 58.8)

0.123a

Vitamin D status (%)

239

   

0.358b

Deficiency (< 50 nmol/L)

 

72 (60)

82 (69)

154 (64)

 

Insufficiency (50 to 75 nmol/L)

 

32 (27)

26 (22)

58 (24)

 

Sufficiency (> 75 nmol/L)

 

16 (13)

11 (9)

27 (11)

 
  1. Data given as median with interquartile range (IQR) or frequency with (%) of patients.
  2. N is the number of non-missing values.
  3. aWilcoxon signed rank test; bMcNemar’s test; cMatched; dOther or None (pancreatitis, multiple transfusions, trauma).