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Table 3 Causes of SIADH

From: Hyponatremia in the intensive care unit: How to avoid a Zugzwang situation?

Paraneoplastic production of AVP

Eutopic production of AVP/ enhanced hypothalamo–pituitary release of AVP

SCLC non-SCLC

CNS disorders

Head and neck cancer

 Infectious: meningitis, encephalitis, brain abscess

 Mesothelioma

 Vascular: SAH, subdural hematoma, thrombosis

 Stomach carcinoma

 Multiple sclerosis

 Duodenum carcinoma

 Acute intermittent porphyria

 Thymoma

 Guillain-Barré syndrome

 Lymphoma

 Shy-Drager syndrome

 Olfactory neuroblastoma

 Schizophrenia

 Bladder carcinoma

Pulmonary disorders

 Sarcoma

 Pneumonia, tuberculosis

Potentiation of AVP effects

 Pneumothorax, atelectasis

 Carbamazepine

 Asthma, cystic fibrosis

 Sodium valproate

 Positive pressure ventilation

 Cyclophosphamide

Drugs

 

 Neuroleptics

 

 TCC, MAOI, and SSRI antidepressants

 

 Antineoplastic drugs

 

Others

 

 Hypopituitarism

 

 Severe hypothyroidism

 

 Nausea, pain

  1. AVP arginine vasopressin, SCLC small cell lung cancer, SAH subarachnoidal hemorrhage, TCC tricyclic antidepressant, MAOI monoamine oxydase inhibitor antidepressant, SSRI selective serotonin uptake inhibitor antidepressant