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Table 2 The number and percentages of total administered and interacting drugs in different drug classes

From: Important drug classes associated with potential drug–drug interactions in critically ill patients: highlights for cardiothoracic intensivists

Drug classes Total administered drugs % (n) D and/or X interacting drugs % (n) D and/or X interacting precipitant drugs with E and/or G reliability % (n)
Anti-infective agents 22.35 % (398) 25.00 % (124) 45.87 % (50)
Central nervous system agents 20.50 % (365) 19.95 % (99) 14.67 % (16)
Cardiovascular drugs 19.21 % (342) 13.10 % (65) 5.50 % (6)
Gastrointestinal drugs 12.80 % (228) 6.65 % (33) 4.58 % (5)
Hormones and synthetic substitutes 6.68 % (119) 11.29 % (56) 2.75 % (3)
Respiratory tract agents 6.40 % (114) 3.22 % (16)
Electrolytic, caloric, and water balance 5.33 % (95) 6.65 % (33) 10.09 (11)
Blood formation, coagulation, and thrombosis 2.07 % (37) 3.42 % (17) 3.67 % (4)
Autonomic drugs 2.02 % (36) 3.02 % (15) 9.17 % (10)
Miscellaneous therapeutic agents 2.02 % (36) 7.05 % (35) 3.66 % (4)
Vitamins 0.56 % (10) 0.60 % (3)
Total 1780 496 109