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Table 4 Comparisons between patients with and without ICU-acquired severe bleeding (n = 279, after excluding 17 patients with bleeding on admission)

From: Platelet transfusions in cancer patients with hypoproliferative thrombocytopenia in the intensive care unit

Variable ICU-acquired severe bleeding
n = 40 patients
No ICU-acquired severe bleeding
n = 239 patients
p
Age 66.5 (57.2–73) 62 (54–69) 0.61
Male gender (%) 27 (67.5 %) 156 (65.3 %) 0.86
Underlying malignancy    1
 Hematologic malignancy 33 (82.5 %) 196 (82 %)  
 Solid tumor 7 (17.5 %) 43 (18 %)  
Bone marrow transplantation 5 (12.5 %) 34 (14.2 %) 0.87
Reasons for ICU admission    
 Sepsis 15 (37.5 %) 124 (51.9 %) 0.12
 Others 25 (62.5 %) 115 (48.1 %) 0.12
Anticoagulant and/or antiplatelet treatment 8 (20 %) 57 (23.8 %) 0.69
Admission severity scores
 SAPS II (points) 69 (34.2–80) 51 (37–57) 0.57
 SOFA (points) 8 (6–11) 7 (5–10.7) 0.32
 Modified SOFA (points) 7 (3–8) 4 (1–7) 0.31
Admission biological values
 Platelet count (×109/L) 50 (26–84) 26 (13–53) <0.001
 Leukopenia 31 (77.5 %) 133 (55.6 %) 0.009
 Bilirubin (μmol/L) 21 (11–77.7) 19 (11–40.7) 0.36
 Serum urea (mmol/L) 10.9 (7.4–16.5) 9.7 (6.8–18.6) 0.20
 Prothrombin time (%) 62 (44–75) 65 (50.2–77) 0.41
Organ failures during ICU stay
 Nadir platelet count (×109/L)a 15 (7–27) 10 (6–19) 0.014
 Organ failure supports
  Renal replacement therapy 17 (42.5 %) 100 (42 %) 1
  Non-invasive ventilation 15 (37.5 %) 102 (42.7 %) 0.60
  Invasive ventilation 28 (70 %) 139 (58.2 %) 0.16
  Vasopressors 30 (75 %) 152 (63.6 %) 0.21
In-ICU mortality 20 (50 %) 86 (36 %) 0.11
  1. Variables are expressed as median (interquartile range) or number (percentage). The modified SOFA score did not include the platelet component
  2. ICU intensive care unit, SAPS II simplified acute physiology score II, SOFA sequential organ failure assessment score
  3. aThe nadir platelet count was the lowest platelet count recorded prior to the first severe bleeding event, or during the whole ICU stay for patients without severe bleeding