Screening of patients with augmented renal clearance in ICU: taking into account the CKD-EPI equation, the age, and the cause of admission

Annals of Intensive Care

Table 1 Demographic and laboratory data

	Total	Patients with ARC (n = 120)	Patients without ARC (n = 240)	p ^#
Age (years), mean ± SD	50 ± 19	39 ± 16	55 ± 18.7	<0.0001*
BMI (kg/m²⁾, mean ± SD	25 ± 4.6	24.65 ± 3.85	25.18 ± 4.94	0.3005
BSA, mean ± SD	1.86 ± 0.22	1.89 ± 0.19	1.86 ± 0.22	0.1291
SAPS II, mean ± SD	46 ± 16	43 ± 15	48 ± 16	0.003*
SOFA, mean ± SD	4.3 ± 1.9	4.1 ± 1.6	4.4 ± 2	0.6373
Diagnosis
PT/NPT	189/171	89/31	100/140	<0.0001*
Sex (F/M)	114/246	30/90	84/156	0.0558
Serum creatinine (µmol/l), mean ± SD	72.14 ± 22.4	63.5 ± 17	76.5 ± 23.6	<0.0001*
Urine (ml/d)	2571 ± 1178	2878 ± 1353	2363 ± 996	0.0018*
Urinary creatinine excretion (mg/d/1.73 m²)	1239.7 ± 686.7	1812 ± 758	953.4 ± 419	<0.0001*
Measured CrCl (ml/min/1.73 m²), mean ± SD	110.75 ± 56.8	173.4 ± 44.3	79.4 ± 30.4	<0.0001*
CG formula (ml/min/1.73 m²), mean ± SD	114.4 ± 41.5	137.6 ± 34.4	98.2 ± 38.5	<0.0001*
Robert formula (ml/min/1.73 m²), mean ± SD	79.7 ± 25.9	94.8 ± 24	72.2 ± 23.3	<0.0001*
sMDRD equation (ml/min/1.73 m²), mean ± SD	112 ± 40.9	132.5 ± 36.9	101.9 ± 39	<0.0001*
CKD-EPI equation (ml/min/1.73 m²), mean ± SD	98.9 ± 25.8	115.4 ± 18.9	90.7 ± 24.9	<0.0001*

BMI body mass index, BSA body surface area (m²), PT polytrauma, NPT non-polytrauma, p ^# comparison between patients with and without ARC, * statistically significant