Fig. 2
From: Tolvaptan for hyponatremia with preserved sodium pool in critically ill patients
Changes in urine output and sodium-free water clearance (upper panel) and in serum and urine osmolality (lower panel) before and 24 h after Tolvaptan. Urine osmolality was calculated either as salt osmolality (i.e., the part of osmolality exerted by strong ions) and, for the subset of patients in whom urinary nitrogen determinations were available, as total urinary osmolality. *p < 0.01 before vs. after Tolvaptan