Table 4 Factors associated with mortality at D28

ICU

 With low refusal rate (HBA)

121 (43.8)

359 (41.7)

1

1

 With high refusal rate (LBA)

155 (56.2)

501 (58.3)

1.09 (0.83–1.43)

1.34 (0.92–1.95)

Age (mean ± SD)

67 ± 14

55 ± 19

1.04 (1.03–1.05)

Sex

 Male (%)

179 (65)

489 (57)

1

1

 Female (%)

97 (35)

371 (43)

0.71 (0.54–0.95)

0.66 (0.45–0.98)

Characteristics on proposal, n (%)

 Shock

134 (48.6)

146 (17.0)

4.73 (3.51–6.37)

1.81 (1.21–2.72)

 Catecholamine infusion

82 (29.7)

66 (7.7)

5.21 (3.63–7.48)

 Glasgow score

9.8 ± 5.0

11.9 ± 4.1

0.90 (0.87–0.93)

 Platelets count <50,000/dl

11 (4.0)

13 (1.5)

2.94 (1.30–6.64)

 Prothrombine time <30 %

24 (8.7)

14 (1.6)

6.17 (3.14–12.11)

2.65 (1.09–6.44)

 Creatinine level >250 µmol/l

46 (16.7)

80 (9.3)

2.19 (1.48–3.25)

 Jaundice

14 (5.1)

22 (2.6)

2.09 (1.05–4.15)

 Mechanical ventilation (all setting)

148 (53.6)

328 (38.1)

1.93 (1.46–2.54)

 NIV

15 (5.4)

54 (6.3)

0.87 (0.48–1.58)

 Oxygen administration >10L/min

67 (24.3)

147 (17.1)

1.59 (1.14–2.21)

Preexisting diseases

 COPD

15 (5.4)

52 (6.0)

0.93 (0.51–1.68)

 Cardiac insufficiency

22 (8.0)

34 (3.9)

2.20 (1.26–3.84)

 Evolutive malignancy

44 (15.9)

105 (12.2)

1.42 (0.97–2.08)

 Cirrhosis

26 (9.4)

31 (3.6)

2.89 (1.68–4.97)

 Renal failure with ERT

8 (2.9)

20 (2.3)

1.30 (0.56–2.98)

Mac Cabe score

 0

81 (31.4)

493 (58.4)

1

1

 1

99 (38.4)

265 (31.4)

2.27 (1.64–3.16)

1.56 (1.02–2.37)

 2

78 (30.2)

86 (10.2)

5.52 (3.75–8.12)

3.66 (2.21–6.06)

SAPS2

62 ± 20

34 ± 16

1.08 (1.07–1.10)

1.08 (1.06–1.09)