Risk factors for and prediction of mortality in critically ill medical–surgical patients receiving heparin thromboprophylaxis

Annals of Intensive Care

Table 4 Sensitivity analyses of model performance in Model 3 using restricted cubic splines for continuous predictors^a for 60-day hospital and 60-day ICU mortality

Model performance	Goodness-of-fit		C index	SMR (95 % CI)
Model performance	p value^b	AIC	C index	SMR (95 % CI)
Hospital mortality in derivation set (n = 1891)^c	0.54	5691	0.63	1.007 (0.963–1.054)
Hospital mortality in validation set (n = 1855)^c	0.51	5924	0.62	0.988 (0.943–1.034)
ICU mortality in the whole set (n = 3746)^d	0.69	8177	0.64	1.005 (0.973–1.037)

AIC Akaike information criterion, SMR standardized mortality ratio
^aContinuous predictors included BMI, APACHE score and the interaction between them for hospital mortality, and continuous predictors only included BMI and APACHE score for ICU mortality
^bBased on Groennesby and Borgan test
^cModel 3 for hospital mortality included BMI, medical admission, inotropes or vasopressors, acetylsalicylic acid or clopidogrel, APACHE II score and the interaction between BMI and APACHE II score
^dModel 3 for ICU mortality consisted of BMI, medical admission, invasive mechanical ventilation and APACHE II score