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Table 5 Per-patient and per-episode glycemic control results for the STAR and SPRINT cohorts in Christchurch and Gyula Hospital ICU

From: Safety, efficacy and clinical generalization of the STAR protocol: a retrospective analysis

  SPRINT Chch STAR Chch STAR Gyula P value
SPRINT Chch, STAR Chch STAR Gyula, STAR Chch
Number patients 292 267 47
Number episodes 355 336 47
Glycemic performance—per-patient raw data
Median [IQR] BG mean 5.9 [5.5–6.3] 7.0 [6.6–7.6] 6.9 [6.6–7.4] <0.05 0.60
Median [IQR] BG SD 1.2 [1.0–1.6] 1.5 [1.2–2.1] 1.6 [1.3–1.9] <0.05 0.50
Median [IQR] BG median 5.7 [5.3–6.1] 6.7 [6.3–7.3] 6.6 [6.3–7.1] <0.05 0.28
# (%) Patients <4.0 mmol/l 181 (62.0 %) 70 (26.3 %) 25 (53.2 %) <0.05 <0.05
# (%) Patients <2.22 mmol/l 1 (0.3 %) 4 (1.5 %) 2 (4.3 %) 0.20 0.22
Glycemic performance—per-episode hourly interpolated
Median [IQR] BG mean 5.8 [5.4–6.2] 6.7 [6.4–7.3] 6.7 [6.5–7.1] <0.05 0.60
Median [IQR] BG SD 1.1 [0.8–1.5] 1.2 [0.9–1.7] 1.3 [1.04–1.5] <0.05 0.23
Median [IQR] BG median 5.6 [5.2–6.0] 6.5 [6.2–7.0] 6.5 [6.3–6.7] <0.05 0.61
% time >10.0 mmol/l 0.0 [0.0–1.6] 1.6 [0.0–6.5] 2.4 [0.7–5.4] <0.05 0.16
% time 4–6.1 mmol/l (SPRINT target) 65.6 [52.4–77.9] 29.8 [12.4–45.9] 33.3 [21.5–40.9] <0.05 0.49
% time 4.4–8.0 mmol/l (STAR target) 93.0 [85.0––97.5] 86.6 [75.0–94.1] 87.1 [79.3–91.1] <0.05 0.81
% time <4.4 mmol/l 7.3 [2.1–16.1] 0.0 [0.0–1.8] 0.9 [0.0–2.8] <0.05 <0.05
% time <4.0 mmol/l 1.4 [0.0–5.71] 0.0 [0.0–0.0] 0.0 [0.0–1.8] <0.05 <0.05
% time <2.22 mmol/l 0.0 [0.0–0.0] 0.0 [0.0–0.0] 0.0 [0.0–0.0] 0.97 0.71
Intervention performance—per episode (excluding not fed)
Median [IQR] mean insulin (U/h) 2.2 [0.0–2.8] 2.7 [1.9–3.5] 3.2 [2.4–4.6] <0.05 <0.05
Total hours not fed (%) 16430 (40.1 %) 2305 (10.0 %) 0 (0.0 %)
Median [IQR] mean goal feed (%) 73 [52–86] 86 [64–97] 80 [74–88] <0.05 0.28
Median[IQR] mean total glucose(g/h) 4.2 [3.1–5.4] 5.1 [4.0–6.2] 7.4 [6.2–8.9] <0.05 <0.05
Median [IQR] mean enteral glucose (g/h) 4.1 [3.0–5.3] 4.5 [2.6–5.6] 3.04 [1.48–5.40] 0.74 <0.05
Median [IQR] mean parenteral glucose (g/h) 0.0 [0.0–0.0] 0.0 [0.0–1.1] 4.05 [2.84–5.69] <0.05 <0.05
  1. Data are presented as median [inter-quartile range (IQR)] where appropriate