Table 1 Baseline characteristics of all patients mechanically ventilated for non-infectious reasons
From: Biomarker kinetics in the prediction of VAP diagnosis: results from the BioVAP study
Total (N = 138) | VAP (N = 35) | No infection (N = 70) | p | |
|---|---|---|---|---|
Male, N (%) | 93 (67.4 %) | 26 (74.3 %) | 41 (58.6 %) | 0.116 |
Age (years) | 59.8 ± 18.4 | 57.9 ± 16.2 | 60.6 ± 20.5 | 0.501 |
SAPS II | 49.1 ± 18.4 | 52.6 ± 18.3 | 49.8 ± 19.0 | 0.479 |
SOFA | 7.2 ± 3.0 | 8.1 ± 2.9 | 6.8 ± 2.9 | 0.045 |
CPIS | 2.6 ± 1.9 | 2.7 ± 2.0 | 2.7 ± 1.9 | 0.971 |
Cause of admission, N (%) | 0.581 | |||
Medical | 96 (69.6 %) | 25 (71.4 %) | 50 (71.4 %) | |
Trauma | 2 (1.4 %) | 8 (22.9 %) | 11 (15.7 %) | |
Elective surgery | 27 (19.6 %) | 0 | 1 (1.4 %) | |
Emergency surgery | 13 (9.4 %) | 2 (5.7 %) | 8 (11.4 %) | |
Comorbidities, N (%) | ||||
COPD | 19 (13.8 %) | 7 (20.0 %) | 6 (8.6 %) | 0.119 |
Steroids | 1 (0.7 %) | 1 (1.4 %) | ||
Diabetes | 19 (13.8 %) | 3 (8.6 %) | 12 (17.1 %) | 0.375 |
Immunosuppression | 3 (2.2 %) | 1 (1.4 %) | ||
CHF | 23 (16.7 %) | 3 (8.6 %) | 14 (20.0 %) | 0.167 |
CLD | 1 (0.7 %) | 1 (2.9 %) | ||
CRF | 9 (6.5 %) | 3 (8.6 %) | 6 (8.6 %) | 1.0 |
HIV | 3 (2.2 %) | 1 (2.9 %) | 2 (2.9 %) | 1.0 |
Admission diagnosis, N (%) | 0.501 | |||
CVA | 16 | 6 | 10 | |
AECB | 6 | 2 | 4 | |
Decompensated CHF | 17 | 5 | 12 | |
TBI | 19 | 10 | 9 | |
Others | 28 | 14 | 14 | |
Reason of MV, N (%) | 0.1 | |||
Respiratory failure | 40 (29.0 %) | 8 (22.9 %) | 23 (32.9 %) | |
Shock | 17 (12.3 %) | 8 (22.9 %) | 5 (7.1 %) | |
Coma | 76 (55.1 %) | 17 (48.6 %) | 40 (51.7 %) | |
Other | 5 (3.6 %) | 2 (5.7 %) | 2 (2.9 %) | |
Tidal volume (mL) | 458 [146] | 488 [97] | 442 [160] | 0.21 |
Plateau pressure (cmH2O) | 19 [7] | 21 [9] | 19 [6] | 0.213 |
PEEP | 5 [2] | 5 [3] | 5 [2] | 0.686 |
PaO2/FiO2 | 245 [172] | 245 [122] | 224 [213] | 0.828 |
CPR (mg/dL) | 6.00 [8.62] | 4.33 [6.20] | 8.40 [9.39] | 0.003 |
PCT (μg/L) | 0.40 [1.76] | 0.94 [2.37] | 0.34 [1.48] | 0.167 |
MR-proADM (nmol/L) | 1.85 [2.64] | 1.70 [2.87] | 1.91 [2.82] | 0.470 |
WCC (×103/mm3) | 12.46 ± 4.55 | 12.58 ± 4.92 | 11.85 ± 4.54 | 0.456 |
Temperature (°C) | 36.7 ± 1.3 | 36.9 ± 1.3 | 36.4 ± 1.3 | 0.126 |
Nosocomial infectiona | 68 (49.3 %) | |||
VAP | 35 (25.4 %) | |||
VAT | 14 (10.1 %) | |||
CVC bacteremia | 2 (1.4 %) | |||
UTI | 6 (4.3 %) | |||
Surgical infection | 5 (3.6 %) | |||
Other | 6 (4.3 %) | |||
Duration of MV (days) | 7.5 [9.8] | 14.0 [8.0] | 5.0 [5.5] | <0.001 |
LOS ICU (days) | 12.0 [12.0] | 18.0 [12.0] | 10.0 [8.5] | <0.001 |
LOS hospital (days) | 25.0 [30.3] | 27.0 [31.5] | 24.0 [30.5] | 0.55 |
Mortality D28, N (%) | 16 (18.6) | 15 (40.5) | 1 (2) | <0.001 |
Mortality D90, N (%) | 20 (23.3) | 15 (40.5) | 5 (10.2) | 0.004 |