Biomarker kinetics in the prediction of VAP diagnosis: results from the BioVAP study

Annals of Intensive Care

Table 2 Evaluation of studied variables in ventilator-associated pneumonia prediction

	OR	95 % CI	p	aOR	95 % CI	p
Slope
CRP (mg/dL)	1.641	1.229–2.192	<0.001	1.624	1.206–2.189	0.001
CRP ratio	1.516	1.021–2.250	0.039	1.480	1.060–2.067	0.021
PCT (μg/L)	0.803	0.544–1.183	0.267	0.844	0.559–1.274	0.419
ADM (nmol/L)	0.740	0.147–3.742	0.716	0.730	0.137–3.902	0.713
WCC (×10³/mm³)	1.182	0.807–1.729	0.391	1.225	0.809–1.855	0.338
Temperature (°C)	0.288	0.033–2.540	0.262	0.270	0.028–2.590	0.256
Highest
CRP (mg/dL)	1.044	1.000–1.090	0.052	1.037	0.992–1.085	0.11
CRP ratio	1.201	1.065–1.355	0.003	1.202	1.061–1.363	0.004
PCT (μg/L)	1.032	0.987–1.079	0.168	1.020	0.974–1.068	0.392
ADM (nmol/L)	1.335	1.022–1.744	0.034	1.369	1.035–1.809	0.028
WCC (×10³/mm³)	1.032	0.987–1.079	0.168	1.020	0.974–1.068	0.392
Temperature (°C)	2.043	1.170–3.536	0.012	2.053	1.126–3.744	0.019
Δ ^max
CRP (mg/dL)	1.151	1.057–1.252	0.001	1.139	1.039–1.248	0.006
CRP ratio	1.213	1.030–1.428	0.021	1.186	1.018–1.381	0.029
PCT (μg/L)	1.036	0.984–1.089	0.178	1.023	0.971–1.078	0.399
ADM (nmol/L)	1.395	0.964–2.020	0.078	1.372	0.943–1.996	0.099
WCC (×10³/mm³)	1.044	0.963–1.131	0.294	1.046	0.959–1.140	0.312
Temperature (°C)	1.020	0.665–1.565	0.928	0.933	0.583–1.494	0.772

Variables included in the adjusted model: age, sex, SAPS II, cause of admission
Simplified CPIS Clinical Pulmonary Infection Score, CRP C-reactive protein, MR-proADM mid-region fragment of pro-adrenomedullin, OR odds ratio, PCT procalcitonin, ROC receiver operating characteristics, VAP ventilator-associated pneumonia, WCC white cell count