Table 1 Clinical characteristics of the study population
From: Prognostic impact of left ventricular diastolic function in patients with septic shock
Parameters | Global population (n = 223) | Survivors (n = 145) | Non-survivors (n = 78) | p |
|---|---|---|---|---|
Patients characteristics | ||||
Age (years) | 64 ± 13 | 63 ± 13 | 64 ± 13 | 0.74 |
Male (n) | 140 (63) | 93 (64) | 47 (60) | 0.57 |
SAPS II | 55 ± 18 | 49 ± 15 | 66 ± 17 | <0.0001 |
SOFA | 10 ± 3 | 9 ± 3 | 11 ± 3 | <0.0001 |
Charlson | 3.5 ± 2.5 | 3.4 ± 2.6 | 3.6 ± 2.1 | 0.56 |
Cancer (n) | 35 (16) | 23 (16) | 12 (15) | 0.93 |
Hematologic malignancy (n) | 10 (4) | 1 (0.7) | 9 (12) | 0.0004 |
Chronic renal failure (n) | 14 (6) | 7 (5) | 7 (9) | 0.22 |
Cirrhosis (n) | 12 (5) | 5 (3) | 7 (9) | 0.08 |
Infection characteristics | ||||
Documented infection | 185 (83) | 123 (85) | 62 (80) | 0.31 |
Bacteremia | 105 (47) | 65 (45) | 40 (51) | 0.36 |
Abdominal | 87 (39) | 57 (41) | 30 (41) | 0.96 |
Pulmonary | 48 (22) | 31 (22) | 17 (23) | 0.94 |
Urogenital | 37 (17) | 26 (19) | 11 (15) | 0.46 |
Skin or joint and bones | 12 (5) | 1 (7) | 3 (4) | 0.14 |
Other origin | 30 (13) | 16 (13) | 13 (15) | 0.21 |
Biology | ||||
pH | 7.30 ± 0.14 | 7.32 ± 0.12 | 7.27 ± 0.17 | 0.03 |
Lactates (mmol/L) | 4.9 ± 4.4 | 4.1 ± 3.7 | 6.3 ± 5.3 | 0.0004 |
PaO2/FiO2 | 177 ± 113 | 180 ± 116 | 171 ± 108 | 0.57 |
Creatinine (µmol/L) | 196 ± 143 | 180 ± 140 | 225 ± 144 | 0.03 |
Bilirubin (µmol/L) | 22 ± 35 | 20 ± 24 | 27 ± 49 | 0.12 |
ALAT (IU/L) | 134 ± 335 | 115 ± 302 | 167 ± 389 | 0.28 |
Hemoglobin (g/dL) | 11 ± 2 | 11 ± 2 | 11 ± 3 | 0.69 |
White blood cells (G/L) | 15.5 ± 14.5 | 15.5 ± 12.3 | 15.6 ± 18.1 | 0.93 |
Platelets (G/L) | 211 ± 151 | 217 ± 157 | 199 ± 138 | 0.40 |
DIC (n) | 21 (9) | 11 (8) | 10 (13) | 0.002 |
Treatment characteristics | ||||
Delay of antibiotic therapy (h) | 2.7 ± 7.1 | 1.8 ± 4.0 | 4.3 ± 10.6 | 0.02 |
Antibiotics administered <3 h | 174 (78) | 119 (84) | 55 (71) | 0.06 |
Appropriate initial antibiotic therapy | 198 (88) | 135 (93) | 63 (81) | 0.005 |
Fluid therapy (L) | 4.4 ± 3.7 | 4.4 ± 3.6 | 4.6 ± 3.9 | 0.74 |
Noradrenaline (n) | 205 (92) | 134 (95) | 71 (91) | 0.72 |
Epinephrine (n) | 68 (30) | 33 (23) | 35 (45) | 0.0006 |
Dobutamine (n) | 11 (5) | 6 (4) | 5 (6) | 0.45 |
Maximal dose of vasopressorsa (µg/kg/min) | 0.79 ± 0.85 | 0.55 ± 0.47 | 1.25 ± 1.17 | <0.0001 |
Hydrocortisone Hemisuccinate (n) | 22 (10) | 11 (8) | 11 (14) | 0.12 |
Renal replacement therapy | 38 (17) | 19 (13) | 19 (24) | 0.04 |
Invasive mechanical ventilation | 204 (91) | 127 (88) | 77 (99) | 0.0012 |