Table 1 Demographics and clinical characteristics upon ICU admission of ARDS patients with (Aspergillus +) or without (Aspergillus −) one or more respiratory tract sample positive for Aspergillus spp.
All (n = 423) | Aspergillus − (n = 388) | Aspergillus + (n = 35) | p value | |
|---|---|---|---|---|
Age (years) | 62 (50–72) | 62 (50–72) | 62 (49–72) | 0.82 |
Gender (male) | 282 (67) | 258 (66) | 24 (69) | 0.85 |
Previously known aspergillosis | 8 (2) | 7 (2) | 1 (3) | 0.50 |
Immunosuppression | 100 (24) | 86 (22) | 14 (40) | 0.023 |
COPD | 48 (11) | 44 (11) | 4 (11) | >0.99 |
Inhaled steroids | 16 (4) | 15 (4) | 1 (3) | >0.99 |
Liver cirrhosis | 44 (10) | 42 (11) | 2 (6) | 0.56 |
Chronic renal failure | 16 (4) | 15 (4) | 1 (3) | >0.99 |
Diabetes mellitus | 85 (20) | 79 (20) | 6 (17) | 0.83 |
SAPS II | 53 (37–69) | 53 (38–70) | 51 (34–68) | 0.65 |
LODS | 8 (6–12) | 8 (6–12) | 7 (5–11) | 0.26 |
Main ARDS risk factors | ||||
Pulmonary infection | 202 (48) | 173 (45) | 29 (83) | <0.0001 |
Aspiration | 154 (36) | 147 (38) | 7 (20) | 0.043 |
Non-pulmonary sepsis | 87 (21) | 84 (22) | 3 (9) | 0.080 |
Drug overdose | 12 (3) | 11 (3) | 1 (3) | >0.99 |
Delay first respiratory symptom—admission, days | 2 (0–5) | 2 (0–5) | 2 (0–8) | 0.41 |
Temperature > 38.3 °C | 220 (52) | 199 (51) | 21 (60) | 0.38 |
Noninvasive ventilation | 69 (16) | 65 (17) | 4 (11) | 0.63 |
Berlin classification | 0.38 | |||
Mild | 113 (27) | 104 (27) | 9 (26) | |
Moderate | 162 (38) | 144 (37) | 18 (51) | |
Severe | 148 (35) | 140 (36) | 8 (23) | |
PaO2/FiO2 ratio (mm Hg) | 106 (77–163) | 106 (78–162) | 114 (76–173) | 0.84 |
Shock | 325 (77) | 297 (76) | 28 (80) | 0.83 |
Serum creatinine (µmol/L) | 120 (82–180) | 120 (82–177) | 128 (82–207) | 0.76 |