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Table 3 Serum urea, serum creatinine, 24-h urine output, diuretics, urea and creatinine clearance, 24-h urinary urea and creatinine, urea and creatinine generation rate, urinary urea/urea generation rate and urinary creatinine/creatinine generation rate ratios at the day (D0) of attempt of weaning and the following two days (D1, D2)

From: Daily urinary creatinine predicts the weaning of renal replacement therapy in ICU acute kidney injury patients

  D0 D1 D2
S+ S p S+ S p S+ S p
S urea (mmol/l) 10 [7.6–13] 7.3 [6.2–12] 0.56 16 [12–24] 17 [14–21] 0.26 22 [15–37] 24 [20–27] 0.54
S creat (µmol/l) 105 [73–170] 83 [64–117] 0.36 177 [136–294] 158 [115–197] 0.15 227 [137–309] 218 [155–314] 0.65
24-h urinary output (l) 2.3 [1.5–3.5] 1.9 [1.0–2.5] 0.05 2.4 [1.8–3.7] 2.6 [1.7–3.3] 0.46 2.7 [2.1–3.4] 2.5 [1.7–3.3] 0.32
Use of furo [n (%)] 19 (73) 24 (86) 0.42 15 (59) 25 (89) 0.009 9 (35) 21 (75) 0.005
Dose of furo (mg/24 h) 470 [215–1000] 1000 [483–1000] 0.06 500 [125–970] 1000 [500–1000] 0.01 500 [250–1000] 1000 [500–1000] 0.01
Diuretic RI (ml/mg) 6 [2.9–15.4] 2.1 [1.1–6.4] 0.02 4.6 [3.6–26.4] 3.2 [1.9–4.3] 0.06 5.8 [2.5–8.2] 3.4 [2.6–5.8] 0.09
UrCl (ml/min) 15 [8–20] 6 [4–12] 0.008 12.5 [8–20] 7 [5–9] 0.001 13 [9–18] 6 [4–8] <0.001
CrCl (ml/min) 31 [15–41] 18 [7–26] 0.009 31 [18–40] 15 [8–21] 0.002 31 [16–42] 13 [6–21] <0.001
UUr (mmol/24 h) 187 [72–339] 85.9 [44–157] 0.031 357 [195–569] 147 [95–224] 0.002 592 [230–672] 236 [113–272] 0.002
UCr (mmol/24 h) 4.9 [2.5–6.4] 2.55 [0.7–3.9] 0.002 6.65 [5–8.8] 3.5 [1.6–4.4] <0.001 8.1 [6–9.5] 4.4 [2.2–5.2] <0.001
UrGR (µmol/min)     530 [331–722] 318 [254–442] 0.02 428 [257–681] 305 [232–393] 0.08
CrGR (µmol/min)     6.8 [5.8–9.9] 4.1 [2.9–5.2] <0.001 6.2 [4.8–7.8] 4 [3.4–4.9] 0.002
UUr/UrGR (%)     51 [36–61] 36 [24–48] 0.03 71 [62–84] 48 [31–60] <0.001
UCr/CrGR (%)     72 [53–85] 57 [40–67] 0.047 94 [77–100] 67 [44–82] <0.001
  1. Italic values indicate significance of p value (p <0.05)
  2. Results are displayed in median [interquartile range] if quantitative variable; and number and percentage if categorial variable
  3. p: differences between S+ and S groups
  4. S urea serum urea, S creat serum creatinine, Furo furosemide, Diuretic RI diuretic response index, Cl clearance, UUr urinary urea, UCr urinary creatinine, UrGR urea generation rate, CrGR creatinine generation rate, Ur urea, Cr creatinine