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Annals of Intensive Care

Table 3 Serum urea, serum creatinine, 24-h urine output, diuretics, urea and creatinine clearance, 24-h urinary urea and creatinine, urea and creatinine generation rate, urinary urea/urea generation rate and urinary creatinine/creatinine generation rate ratios at the day (D0) of attempt of weaning and the following two days (D1, D2)

From: Daily urinary creatinine predicts the weaning of renal replacement therapy in ICU acute kidney injury patients

 

D0

D1

D2

S+

S−

p

S+

S−

p

S+

S−

p

S urea (mmol/l)

10 [7.6–13]

7.3 [6.2–12]

0.56

16 [12–24]

17 [14–21]

0.26

22 [15–37]

24 [20–27]

0.54

S creat (µmol/l)

105 [73–170]

83 [64–117]

0.36

177 [136–294]

158 [115–197]

0.15

227 [137–309]

218 [155–314]

0.65

24-h urinary output (l)

2.3 [1.5–3.5]

1.9 [1.0–2.5]

0.05

2.4 [1.8–3.7]

2.6 [1.7–3.3]

0.46

2.7 [2.1–3.4]

2.5 [1.7–3.3]

0.32

Use of furo [n (%)]

19 (73)

24 (86)

0.42

15 (59)

25 (89)

0.009

9 (35)

21 (75)

0.005

Dose of furo (mg/24 h)

470 [215–1000]

1000 [483–1000]

0.06

500 [125–970]

1000 [500–1000]

0.01

500 [250–1000]

1000 [500–1000]

0.01

Diuretic RI (ml/mg)

6 [2.9–15.4]

2.1 [1.1–6.4]

0.02

4.6 [3.6–26.4]

3.2 [1.9–4.3]

0.06

5.8 [2.5–8.2]

3.4 [2.6–5.8]

0.09

UrCl (ml/min)

15 [8–20]

6 [4–12]

0.008

12.5 [8–20]

7 [5–9]

0.001

13 [9–18]

6 [4–8]

<0.001

CrCl (ml/min)

31 [15–41]

18 [7–26]

0.009

31 [18–40]

15 [8–21]

0.002

31 [16–42]

13 [6–21]

<0.001

UUr (mmol/24 h)

187 [72–339]

85.9 [44–157]

0.031

357 [195–569]

147 [95–224]

0.002

592 [230–672]

236 [113–272]

0.002

UCr (mmol/24 h)

4.9 [2.5–6.4]

2.55 [0.7–3.9]

0.002

6.65 [5–8.8]

3.5 [1.6–4.4]

<0.001

8.1 [6–9.5]

4.4 [2.2–5.2]

<0.001

UrGR (µmol/min)

   

530 [331–722]

318 [254–442]

0.02

428 [257–681]

305 [232–393]

0.08

CrGR (µmol/min)

   

6.8 [5.8–9.9]

4.1 [2.9–5.2]

<0.001

6.2 [4.8–7.8]

4 [3.4–4.9]

0.002

UUr/UrGR (%)

   

51 [36–61]

36 [24–48]

0.03

71 [62–84]

48 [31–60]

<0.001

UCr/CrGR (%)

   

72 [53–85]

57 [40–67]

0.047

94 [77–100]

67 [44–82]

<0.001

  1. Italic values indicate significance of p value (p <0.05)
  2. Results are displayed in median [interquartile range] if quantitative variable; and number and percentage if categorial variable
  3. p: differences between S+ and S− groups
  4. S urea serum urea, S creat serum creatinine, Furo furosemide, Diuretic RI diuretic response index, Cl clearance, UUr urinary urea, UCr urinary creatinine, UrGR urea generation rate, CrGR creatinine generation rate, Ur urea, Cr creatinine
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