The critical care response to a hospital outbreak of Middle East respiratory syndrome coronavirus (MERS-CoV) infection: an observational study

Al-Dorzi, Hasan M.; Aldawood, Abdulaziz S.; Khan, Raymond; Baharoon, Salim; Alchin, John D.; Matroud, Amal A.; Al Johany, Sameera M.; Balkhy, Hanan H.; Arabi, Yaseen M.

doi:10.1186/s13613-016-0203-z

Annals of Intensive Care

Table 2 Characteristics, management and outcomes for healthcare workers (n = 8) infected with MERS-CoV and admitted to the intensive care unit during the outbreak

From: The critical care response to a hospital outbreak of Middle East respiratory syndrome coronavirus (MERS-CoV) infection: an observational study

Job	Patient 1	Patient 2	Patient 3	Patient 4	Patient 5	Patient 6	Patient 7	Patient 8
Job	Ward nurse	Ward nurse	Clinic nurse	Physician	RT technician	ED transporter	Executive	AC technician
Clinical presentation
Dyspnea	Yes	Yes	Yes	Yes	Yes	Yes	Yes	Yes
Body temperature	39.4 °C	38.9 °C	37.9 °C	38.3 °C	39.5 °C	39.4 °C	39.0 °C	38.9 °C
WBC × 10⁹/L	11.6	13.1	3.5	5.9	5.1	6.0	3.7	6.8
Shock	Yes	Yes	Yes	No	Yes	Yes	Yes	Yes
PaO₂/FIO₂	71	91	56	453	64	100	107	126
CXR findings	Bilateral lower lobe infiltrates	Right lower lobe infiltrates	Diffuse bilateral infiltrate	Bilateral lower lobe infiltrates	Right lower lobe infiltrates	Diffuse bilateral infiltrates	Left lower lobe infiltrates	Left lower lobe infiltrates
Management
Noninvasive ventilation	Yes (failed)	No	No	No	No	No	Yes (failed)	No
Intubation	Yes	Yes	Yes	No	Yes	Yes	Yes	Yes
ARDS management	Cisatracurium infusion; prone positioning	Cisatracurium infusion; prone positioning; inhaled nitric oxide	Cisatracurium infusion	NA	Cisatracurium infusion	Cisatracurium infusion	Cisatracurium infusion; prone positioning; inhaled nitric oxide	Cisatracurium infusion; prone positioning
Vasopressors	Yes	Yes	Yes	No	Yes	Yes	Yes	Yes
CVVHD (duration)	No	Yes (26 days)	No	No	No	Yes (6 days)	Yes (37 days)	Yes (47 days)
ECMO (duration)	No	Yes (15 days)	No	No	No	No	No	No
Tracheostomy	No	No	No	No	No	No	Yes (surgical; on day 25 after intubation)	Yes (surgical; on day 30 after intubation)
Outcomes
MV duration (days)	20	26	13	0	13	6	33	57
ICU LOS (days)	28	28	17	3	16	7	56	63
Hospital LOS (days)	44	42	31 days	7	22	26	66	101
Vital status at hospital discharge	Survived	Survived	Survived	Survived	Survived	Survived	Survived	Survived

WBC white blood cells, PaO ₂ /FiO ₂ ratio of arterial oxygen partial pressure to fractional inspired oxygen, CXR chest X-ray, MV mechanical ventilation, ARDS acute respiratory distress syndrome, CVVHD continuous venovenous hemodialysis, ECMO extracorporeal membrane oxygenation, ICU intensive care unit, LOS length of stay, RT respiratory therapist, ED emergency department, AC air condition

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