Table 1 Univariable comparisons of baseline characteristics between ICU patients with and without ICDSC ≥4 during bloodstream infections (n = 240)

Demographics

 Age (years; median, IQR)

63

48–72

70

60–78

<0.001

 Female (n, %)

40

42.1

39

26.9

0.014

 Male (n, %)

55

57.9

106

73.1

Clinical features

 SAPS II (median, IQR)

47

34–64

52

38–69

0.070

 Main principal diagnoses (n, %) not mutual exclusive

  Cardiac disease

58

61.1

103

71.0

0.108

  Pulmonary disease (other than ARDS/ALI)

58

61.1

76

52.4

0.188

  ARDS/ALI

9

9.5

10

6.9

0.474*

  Gastrointestinal tract disease

46

48.4

74

51.0

0.692

  Acute ischemic stroke

7

7.4

17

11.7

0.379*

  Seizure or status epilepticus

5

5.3

8

5.5

  Intracranial hemorrhage

3

3.2

6

4.1

  Polytrauma

5

5.3

4

2.8

  Traumatic brain injury

4

4.2

2

1.4

  Hypoxic ischemic encephalopathy

2

2.1

3

2.1

  Surgery

50

52.6

81

55.9

0.623

   Gastrointestinal tract surgery

19

20.0

17

11.7

0.079

   Cardiac surgery

4

4.2

13

9.0

0.203*

   Thoracic surgery

2

2.1

7

4.8

   Brain surgery

1

1.1

2

1.4

   Other surgery

24

25.3

42

29.0

0.530

  Cardiopulmonary resuscitation

16

16.8

34

23.5

0.218

 Comorbidities

  Charlson Comorbidity Index (median, IQR)

2

1–4

3

1–4

0.415

  Immunosuppression (n, %)

48

50.5

65

44.8

0.387

  Liver and/or renal insufficiency (n, %)

19

20

42

29

0.119

  Drug abuse (n, %)

10

10.5

28

19.3

0.068

  Remote ischemic stroke (n, %)

8

8.4

20

13.8

0.205

  Leukoencephalopathy (n, %)

3

3.2

10

6.9

0.256

  Dementia (n, %)

2

2.1

8

5.5

0.323

  Epilepsy (n, %)

3

3.2

3

2.1

  Remote cerebral hemorrhage (n, %)

1

1.1

5

3.5

  Chronic alcohol intake

1

1.1

4

2.8

Transient episodes of coma on day before BSI diagnosis

17

17.9

38

26.2

0.134

SAS (median, IQR)

3

2–4

3

3–5

0.104

C-reactive protein (mg/l)

Median

IQR

Median

IQR

  C-reactive protein on day before BSI diagnosis

113

41–209

121

73–225

0.299

  C-reactive protein on day of BSI diagnosis

136

62–239

154

80–267

0.364

  C-reactive protein on day after BSI diagnosis

159

82–281

178

103–285

0.409

Leukocytes (×10⁹/l)

  Leukocytes on day before BSI diagnosis

12

8–18

12

8–16

0.862

  Leukocytes on day of BSI diagnosis

13

8–18

12

8–18

0.853

  Leukocytes on day after BSI diagnosis

12

7–18

13

9–18

0.147

Albumin (g/l)

  Albumin at admission

23

16–28

18

15–23

0.026

  Albumin on day of BSI diagnosis

21

16–26

18

14–23

0.045