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Table 5 Multivariate analysis of risk factors for in-intensive care unit mortality

From: Impact of a high loading dose of amikacin in patients with severe sepsis or septic shock

Variables Adjusted odds ratio (CI 95%) P value
Age (per year increment) 1.044 (1.01–1.08) 0.02
Norepinephrine (per µg/kg/min increment) 3.94 (1.9–8.15) 0.0001
Amikacin C max
 Between 60 and 80 mg/L Reference Reference
 <60 mg/L 1.92 (0.46–8.24) 0.4
 >80 mg/L 3.96 (1.54–10.2) 0.004
Prothrombin time 0.98 (0.96–1.01) 0.118
PaO2/FiO2 ratio 0.99 (0.99–1) 0.28
Diabetes mellitus 1.6 (0.59–4.38) 0.32
Glomerular filtration rate (mL/min) 0.99 (0.98–1.01) 0.43
Lactate level 1.01 (0.89–1.14) 0.53
SOFA 1.03 (0.81–1.3) 0.18
  1. The Hosmer–Lemeshow goodness-of-fit test P value was 0.248. The Nagelkerke and Cox/Snell R 2 were, respectively, 0.347 and 0.258
  2. CI confidence intervals, C max peak plasma concentration, PaO 2 /FiO 2 partial O2 pressure in arterial blood/fraction of the inspired oxygen ratio, SOFA Sequential Organ Failure Assessment