Table 5 Multivariate analysis of risk factors for in-intensive care unit mortality
From: Impact of a high loading dose of amikacin in patients with severe sepsis or septic shock
Variables | Adjusted odds ratio (CI 95%) | P value |
|---|---|---|
Age (per year increment) | 1.044 (1.01–1.08) | 0.02 |
Norepinephrine (per µg/kg/min increment) | 3.94 (1.9–8.15) | 0.0001 |
Amikacin C max | ||
Between 60 and 80 mg/L | Reference | Reference |
<60 mg/L | 1.92 (0.46–8.24) | 0.4 |
>80 mg/L | 3.96 (1.54–10.2) | 0.004 |
Prothrombin time | 0.98 (0.96–1.01) | 0.118 |
PaO2/FiO2 ratio | 0.99 (0.99–1) | 0.28 |
Diabetes mellitus | 1.6 (0.59–4.38) | 0.32 |
Glomerular filtration rate (mL/min) | 0.99 (0.98–1.01) | 0.43 |
Lactate level | 1.01 (0.89–1.14) | 0.53 |
SOFA | 1.03 (0.81–1.3) | 0.18 |