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Table 4 Associations of changes in plasma concentrations from baseline to day 4 and day 8 with 6-month mortality in medical and non-medical critically ill patients

From: Glutamine, fish oil and antioxidants in critical illness: MetaPlus trial post hoc safety analysis

Immunonutrient Baseline to day 4 Baseline to day 8
Coef. SE Hazard ratio 95% CI of the hazard ratio P value Coef. SE Hazard ratio 95% CI of the hazard ratio P value
4a: Medical patients
Glutamine (μmol/L) −0.002 0.001 0.998 [0.996, 1.000] 0.111 −0.001 0.001 0.999 [0.996, 1.001] 0.302
(epa + dha)/lcf ratio (×10−2) 0.162 0.070 1.176 [1.023, 1.348] 0.021 0.055 0.053 1.057 [0.949, 1.170] 0.294
Selenium (μmol/L) 0.487 0.457 1.628 [0.644, 3.892] 0.286 −0.551 0.615 0.576 [0.159, 1.776] 0.370
Vit E (μmol/L) −0.005 0.015 0.995 [0.964, 1.024] 0.758 0.009 0.012 1.009 [0.985, 1.031] 0.446
Vit C (μmol/L) −0.006 0.011 0.994 [0.971, 1.016] 0.614 −0.001 0.011 0.999 [0.976, 1.020] 0.944
Zinc (μmol/L) −0.013 0.049 0.988 [0.890, 1.080] 0.799 −0.093 0.064 0.912 [0.794, 1.020] 0.145
4b: Non-medical patients
Glutamine (μmol/L) 0.001 0.001 1.001 [0.999, 1.003] 0.439 0.002 0.001 1.002 [0.999, 1.004] 0.180
(epa + dha)/lcf ratio (×10−2) −0.015 0.057 0.985 [0.876, 1.095] 0.793 −0.040 0.050 0.961 [0.866, 1.057] 0.431
Selenium (μmol/L) 0.353 0.359 1.424 [0.675, 2.807] 0.324 −0.530 0.440 0.589 [0.238, 1.326] 0.228
Vit E (μmol/L) −0.010 0.013 0.990 [0.965, 1.014] 0.429 −0.005 0.012 0.995 [0.971, 1.018] 0.667
Vit C (μmol/L) −0.005 0.014 0.995 [0.968, 1.021] 0.700 −0.009 0.013 0.991 [0.966, 1.016] 0.499
Zinc (μmol/L) −0.028 0.053 0.973 [0.873, 1.074] 0.600 −0.102 0.051 0.903 [0.812, 0.991] 0.045
  1. The coefficient is the Cox proportional hazard regression parameter estimate; a positive coefficient indicates a worse prognosis and a negative coefficient indicates a protective effect of the variable on 6-month mortality. Coefficient values represent changes per unit of nutrient for the different immunonutrients and change per percentage for (epa + dha)/lcf ratio. SE is the parameter estimate standard regression. CI confidence interval. P values represent Chi-square statistic testing the null hypothesis that the estimate is zero