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Annals of Intensive Care

Table 4 Associations of changes in plasma concentrations from baseline to day 4 and day 8 with 6-month mortality in medical and non-medical critically ill patients

From: Glutamine, fish oil and antioxidants in critical illness: MetaPlus trial post hoc safety analysis

Immunonutrient

Baseline to day 4

Baseline to day 8

Coef.

SE

Hazard ratio

95% CI of the hazard ratio

P value

Coef.

SE

Hazard ratio

95% CI of the hazard ratio

P value

4a: Medical patients

Glutamine (μmol/L)

−0.002

0.001

0.998

[0.996, 1.000]

0.111

−0.001

0.001

0.999

[0.996, 1.001]

0.302

(epa + dha)/lcf ratio (×10−2)

0.162

0.070

1.176

[1.023, 1.348]

0.021

0.055

0.053

1.057

[0.949, 1.170]

0.294

Selenium (μmol/L)

0.487

0.457

1.628

[0.644, 3.892]

0.286

−0.551

0.615

0.576

[0.159, 1.776]

0.370

Vit E (μmol/L)

−0.005

0.015

0.995

[0.964, 1.024]

0.758

0.009

0.012

1.009

[0.985, 1.031]

0.446

Vit C (μmol/L)

−0.006

0.011

0.994

[0.971, 1.016]

0.614

−0.001

0.011

0.999

[0.976, 1.020]

0.944

Zinc (μmol/L)

−0.013

0.049

0.988

[0.890, 1.080]

0.799

−0.093

0.064

0.912

[0.794, 1.020]

0.145

4b: Non-medical patients

Glutamine (μmol/L)

0.001

0.001

1.001

[0.999, 1.003]

0.439

0.002

0.001

1.002

[0.999, 1.004]

0.180

(epa + dha)/lcf ratio (×10−2)

−0.015

0.057

0.985

[0.876, 1.095]

0.793

−0.040

0.050

0.961

[0.866, 1.057]

0.431

Selenium (μmol/L)

0.353

0.359

1.424

[0.675, 2.807]

0.324

−0.530

0.440

0.589

[0.238, 1.326]

0.228

Vit E (μmol/L)

−0.010

0.013

0.990

[0.965, 1.014]

0.429

−0.005

0.012

0.995

[0.971, 1.018]

0.667

Vit C (μmol/L)

−0.005

0.014

0.995

[0.968, 1.021]

0.700

−0.009

0.013

0.991

[0.966, 1.016]

0.499

Zinc (μmol/L)

−0.028

0.053

0.973

[0.873, 1.074]

0.600

−0.102

0.051

0.903

[0.812, 0.991]

0.045

  1. The coefficient is the Cox proportional hazard regression parameter estimate; a positive coefficient indicates a worse prognosis and a negative coefficient indicates a protective effect of the variable on 6-month mortality. Coefficient values represent changes per unit of nutrient for the different immunonutrients and change per percentage for (epa + dha)/lcf ratio. SE is the parameter estimate standard regression. CI confidence interval. P values represent Chi-square statistic testing the null hypothesis that the estimate is zero
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