Table 1 Baseline characteristics
Variables | Period 1 (n = 21) | Period 2 (n = 20) | Period 3 (n = 19) | p value |
|---|---|---|---|---|
Men, n (%) | 10 (48) | 10 (50) | 12 (63) | 0.58 |
Age (years) | 73 [58–79] | 66 [56–69] | 66 [47–69] | 0.14 |
APACHE II | 22 [16–29] | 24 [18–32] | 22 [16–27] | 0.81 |
Weight (kg) | 85 [76–90] | 84 [66–104] | 83 [75–100] | 0.91 |
Origin of sepsis, n (%) | ||||
Respiratory | 3 (14) | 9 (45) | 8 (42) | |
Abdominal | 16 (76) | 10 (50) | 10 (53) | |
Cutaneous | 2 (10) | 0 (0) | 0 (0) | 0.14 |
Other | 0 (0) | 1 (5) | 1 (5) | |
Use of ventilator, n (%) | 21 (100) | 20 (100) | 19 (100) | 1.00 |
NE, maximum dose (μg/kg/min) | 0.15 [0.1–0.28] | 0.16 [0.13–0.28] | 0.11 [0.09–0.26] | 0.48 |
Highest lactate (mmol/L) | 2.7 [2.1–4.4] | 2.9 [2.0–3.8] | 2.1 [1.7–3.8] | 0.22 |
Fluids before 1st PLR test (L) | – | 2.1 [1.0–3.7] | 2.3 [0.9–3.2] | 0.81 |