Are third-generation cephalosporins unavoidable for empirical therapy of community-acquired pneumonia in adult patients who require ICU admission? A retrospective study

Annals of Intensive Care

Table 5 Univariable and multivariable analysis of comorbidities associated with infection due to amoxicillin/clavulanate non-susceptible

Comorbidities	Univariable analysis		Multivariable analysis
Comorbidities	OR (95% CI)	P value	OR (CI 95%)	P value
Arterial hypertension	1.3 (0.7–2.2)	0.40
Chronic lung disease	1.7 (0.9–3.1)	0.09	1.9 (1.0–3.6)	0.05
Chronic renal failure	1.6 (0.4–6.0)	0.52
Chronic liver disease	0.7 (0.3–1.6)	0.36
Congestive heart failure	1.2 (0.4–3.3)	0.78
Immunosuppression (HIV, other)	2.0 (0.8–5.1)	0.13
Diabetes mellitus	1.0 (0.4–2.4)	0.97
Cancer	4.3 (2.1–9.1)	0.001	4.5 (2.0–9.8)	0.04
Stroke	0.2 (0.0–1.2)	0.07	0.1 (0.0–0.9)	0.03
Nursing home/non-ambulatory^b	2.1 (0.9–5.0)	0.11	2.9 (1.0–8.2)	0.04
Proton pump inhibitor	1.1 (0.5–2.1)	0.85
Other immunosuppression	2.4 (0.7–8.1)	0.16
Hospitalization^a	1.6 (0.8–3.4)	0.23
Antibiotic during last 90 days	2.7 (1.3–5.6)	0.01	2.7 (1.3–5.9)	0.01

^aAt least 2 days in the last 90 days
^bNon-ambulatory status was defined as being bedridden or using a wheelchair because of difficulty walking