Table 1 Clinical characteristics of the patients

Characteristics

Cohort GRECIA/ABISS

81/41

99/57

n.s

Age (years)

70.5 (18.0)

67.50 (19.0)

n.s

Sex (male)

70 (57.4%)

112 (71.8%)

0.012

Comorbidities

Chronic cardiovascular disease

15 (12.3%)

21 (13.5%)

n.s

Chronic respiratory disease

21 (17.2%)

29 (18.6%)

n.s

Chronic renal failure

12 (9.80%)

16 (10.3%)

n.s

Chronic hepatic failure

2 (1.6%)

11 (7.1%)

0.034

Diabetes mellitus

23 (18.9%)

24 (15.4%)

n.s

Immunosuppression

23 (18.9%)

39 (25.0%)

n.s

Severity and outcome

APACHE-II

18.0 (7.0)

23.0 (10.0)

0.001

Sepsis with cardiovascular dysfunction

77 (63.1%)

147 (94.2%)

0.001

Mortality at the ICU

18 (14.8%)

47 (30.1%)

0.003

Mortality at the hospital

28 (23.0%)

55 (35.3%)

0.026

Source of infection

Respiratory

47 (40.2%)

59 (38.8%)

n.s

Abdominal

38 (32.5%)

44 (29.1%)

n.s

Urinary tract

14 (12.0%)

21 (13.9%)

n.s

Bacteremia–catheter

3 (2.6%)

11 (7.3%)

n.s

Other

15 (12.8%)

15 (9.9%)

n.s

Microbiologically confirmed infection

57 (46.7%)

92 (59.0%)

0.047

Microbiology

Gram-negative bacteria

28 (23%)

55 (35.3%)

0.029

Gram-positive bacteria

31 (25.4%)

35 (22.4%)

n.s

Fungemia

6 (4.9%)

3 (1.9%)

n.s

Other

4 (3.3%)

4 (2.6%)

n.s

Polimicrobian sepsis

16 (13.1%)

11 (7.1%)

n.s

Laboratory parameters at diagnosis

White blood cells (cells/mm3)

15.800 (9500)

15.400 (15,080)

n.s

Platelets/µl

210.000 (136,000)

133.000 (142,500)

0.001

Potassium (mEq/l)

4.2 (0.8)

4.3 (1.0)

n.s

Sodium (mEq/l)

138.0 (8.0)

139.0 (9.0)

n.s

Glycemia (mg/dl)

167.0 (94.0)

170.0 (87.0)

n.s

Creatinine (mg/dl)

1.2 (1.1)

2.0 (1.7)

0.001

Albumin (g/dl)

2.3 (1.0)

2.3 (0.8)

n.s

IgG total (mg/dl)

618.2 (516.0)

528.7 (469.0)

n.s

IgG1 (mg/dl)

482.6 (370.5)

446.71 (377.9)

n.s

IgG2 (mg/dl)

17.8 (28.2)

15.0 (21.2)

n.s

IgG3 (mg/dl)

51.1 (76.0)

49.8 (62.0)

n.s

IgG4 (mg/dl)

17.2 (46.5)

16.3 (35.0)

n.s

IgM (mg/dl)

38.0 (37.4)

36.40 (32.1)

n.s

IgA (mg/dl)

278.7 (343.0)

273.3 (375.6)

n.s