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Table 2 Outcome associated with nosocomial pneumonia, according to aetiology (n = 111)

From: Frequency, associated factors and outcome of multi-drug-resistant intensive care unit-acquired pneumonia among patients colonized with extended-spectrum β-lactamase-producing Enterobacteriaceae

Variables ESBL− (n = 63) ESBL+ (n = 48) p value
Septic shock 21 (33%) 25 (52%) 0.047
SOFA at ICUAP onset 4 [2–9] 7 [4–10] 0.037
Bacteraemia 5 (8%) 7 (15%) 0.26
Appropriate initial first-line antimicrobial therapya 48 (76%) 37 (77%) 0.91
Appropriate 1st beta-lactam 46 (73%) 31(65%) 0.34
Resolution of infectionb 49 (78%) 35 (73%) 0.31
LOS in ICU, all patients 25 [18–41] 33 [19–60] 0.09
LOS in ICU, survivors only 25 [22–41] 40 [27–80] 0.017
LOS in hospital, all patients 41 [23–70] 42 (20–84) 0.81
LOS in hospital, survivors only 57 [40–75] 62 [46–121] 0.29
Death in ICU 24 (38%) 28 (58%) 0.034
Death in hospital 27 (43%) 32 (67%) 0.013
  1. LOS length of stay
  2. aFirst-line antibiotic administered within the first 24 h following ICUAP was deemed appropriate if the isolated pathogen was susceptible to at least one drug administered (including aminoglycosides alone)
  3. bResolution of clinical signs and symptoms of pneumonia without documented microbiologic persistence and alive at day seven