Frequency, associated factors and outcome of multi-drug-resistant intensive care unit-acquired pneumonia among patients colonized with extended-spectrum β-lactamase-producing Enterobacteriaceae

Annals of Intensive Care

Table 2 Outcome associated with nosocomial pneumonia, according to aetiology (n = 111)

Variables	ESBL− (n = 63)	ESBL+ (n = 48)	p value
Septic shock	21 (33%)	25 (52%)	0.047
SOFA at ICUAP onset	4 [2–9]	7 [4–10]	0.037
Bacteraemia	5 (8%)	7 (15%)	0.26
Appropriate initial first-line antimicrobial therapy^a	48 (76%)	37 (77%)	0.91
Appropriate 1st beta-lactam	46 (73%)	31(65%)	0.34
Resolution of infection^b	49 (78%)	35 (73%)	0.31
LOS in ICU, all patients	25 [18–41]	33 [19–60]	0.09
LOS in ICU, survivors only	25 [22–41]	40 [27–80]	0.017
LOS in hospital, all patients	41 [23–70]	42 (20–84)	0.81
LOS in hospital, survivors only	57 [40–75]	62 [46–121]	0.29
Death in ICU	24 (38%)	28 (58%)	0.034
Death in hospital	27 (43%)	32 (67%)	0.013

LOS length of stay
^aFirst-line antibiotic administered within the first 24 h following ICUAP was deemed appropriate if the isolated pathogen was susceptible to at least one drug administered (including aminoglycosides alone)
^bResolution of clinical signs and symptoms of pneumonia without documented microbiologic persistence and alive at day seven