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Table 2 Plasma, arterial blood gas and urine data at 200 min postresuscitation

From: Assessment of renal hemodynamic toxicity of fluid challenge with 0.9% NaCl compared to balanced crystalloid (PlasmaLyte®) in a rat model with severe sepsis

 

0.9% NaCl

n = 20

PlasmaLyte®

n = 20

p

Total fluid requirements (mL) during resuscitation

23 ± 11

23 ± 10

0.99

Plasma at T2

 Sodium (mmol/L)

141 ± 2

138 ± 3

0.017

 Chloride (mmol/L)

117 ± 3

104 ± 3

<0.001

 Potassium (mmol/L)

6.0 ± 0.6

5.3 ± 0.6

0.004

 BUN (mmol/L)

12 ± 3

12 ± 4

0.77

 Creatinine (µmol/L)

34 ± 7

36 ± 6

0.27

 Phosphate (mmol/L)

3.5 ± 0.5

3.6 ± 0.5

0.36

 Calcium (mmol/L)

1.9 ± 0.1

1.9 ± 0.2

0.64

 Osmolarity (mmol/L)

306 ± 8

299 ± 8

0.027

 Hematocrit (%)

44 ± 6

48 ± 4

0.16

 Plasma protein (g/L)

27 ± 3

29 ± 3

0.33

Arterial blood gas

 pH

7.34 ± 0.05

7.44 ± 0.04

<0.001

 Bicarbonate (mmol/L)

20 ± 2

26 ± 2

<0.001

 PaCO2 (mm Hg)

38 ± 5

39 ± 5

0.62

Urine at T2

 Urine output during resuscitation (mL)

1.7 ± 0.4

2.5 ± 0.6

0.002

 Sodium (mmol/L)

52 ± 28

41 ± 15

0.4

 Chloride (mmol/L)

182 ± 56

26 ± 6

<0.001

 Potassium (mmol/L)

168 ± 48

175 ± 54

0.75

 BUN (mmol/L)

533 ± 196

383 ± 161

0.066

 Creatinine (mmol/L)

6.0 ± 2.0

4.2 ± 1.3

0.019

 Sodium/potassium ratio

0.38 ± 0.24

0.29 ± 0.17

0.44

Measured clearance at T2

 Inulin (mL/min)

5.2 ± 2.9

4.4 ± 1.9

0.49

 Creatinine (mL/min)

2.3 ± 1.1

2.3 ± 0.8

0.95