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Table 1 Variables determining oxygenation and lung mechanics in saline controls and LPS-challenged animals

From: Effect of HA330 resin-directed hemoadsorption on a porcine acute respiratory distress syndrome model

Parameter Group Time (h)
Baseline −3 h −2 h −1 h T0
PaO2/FiO2 (mmHg) NS 466 ± 26 458 ± 60 531 ± 51 509 ± 60 479 ± 34
LPS 440 ± 19 312 ± 51 242 ± 36*** 194 ± 10*** 157 ± 23***
PaCO2 (mmHg) NS 35.2 ± 2.8 30.8 ± 2.8 30.5 ± 1.8 32.3 ± 1.1 31.8 ± 1.49
LPS 36.8 ± 2.4 30.2 ± 1.8 37.5 ± 1.5 36.5 ± 3.0 44.7 ± 5.0**
AaDO2 (mmHg) NS 47 ± 7 48 ± 14 52 ± 1 51 ± 12 60 ± 4
LPS 63 ± 5 124 ± 20 143 ± 15** 213 ± 53** 224 ± 48**
PAWPeak (mbar) NS 16.5 ± 1.8 16.5 ± 1.5 16.5 ± 1.7 17.3 ± 2.0 17.3 ± 1.8
LPS 21.3 ± 0.9 27.2 ± 1.8** 30.2 ± 2.4*** 31.2 ± 2.4*** 35.7 ± 2.5***
PAWPlateau (mbar) NS 12.2 ± 1.8 11.5 ± 1.7 12.2 ± 2.0 13.2 ± 2.3 13.8 ± 2.2
LPS 15.3 ± 1.2 18.8 ± 1.4 22.3 ± 2.3** 25.7 ± 2.5*** 27.3 ± 3.2***
Resistance (mbar/l/s) NS 9.3 ± 1.4 7.9 ± 1.2 8.1 ± 1.3 7.5 ± 1.1 8.1 ± 1.3
LPS 8.5 ± 0.4 13.6 ± 2.5 15.7 ± 3.5 15.1 ± 3.2 14.7 ± 2.2
Compliance (ml/mbar) NS 31.2 ± 3.5 33.3 ± 3.0 34.5 ± 4.0 35.6 ± 4.3 32.8 ± 3.3
LPS 28.2 ± 2.7 23.0 ± 2.1 21.4 ± 2.3* 20.7 ± 2.9** 16.7 ± 1.8**
  1. Oxygenation and ventilation parameters in saline control and LPS challenge animals at baseline and a series of time points until the end of the experiment when ALI model was diagnosed (data shown are mean ± SEM, N = 6 of each group; *P < 0.05; **P < 0.01; ***P < 0.001 versus control group). PaO2, oxygen partial pressure; FiO2, inspiratory oxygen fraction; PaCO2, carbon dioxide partial pressure; PAWPeak, peak airway pressure; PAWPlateau, plateau airway pressure