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Table 4 Systemic and pulmonary hemodynamic measurements compared between LPS + HA (sham) and LPS + HA groups

From: Effect of HA330 resin-directed hemoadsorption on a porcine acute respiratory distress syndrome model

Parameter Group Time (h)
Baseline T0 2 h 4 h 6 h 8 h
CO (l/min) LPS + HA (sham) 6.36 ± 0.41 5.50 ± 1.98 4.86 ± 1.28 5.35 ± 1.13 5.17 ± 1.10 5.56 ± 1.27
LPS + HA 4.98 ± 0.48 4.99 ± 0.78 5.34 ± 0.94 6.08 ± 0.97 5.05 ± 0.89 5.15 ± 0.40
MAP (mmHg) LPS + HA (sham) 125 ± 6 82 ± 3 92 ± 20 106 ± 21 104 ± 25 96 ± 24
LPS + HA 118 ± 7 85 ± 15 74 ± 9 86 ± 12 82 ± 17 80 ± 16
SVRI (dyn s/cm5/m2) LPS + HA (sham) 1699 ± 59 1120 ± 154 1813 ± 688 1788 ± 468 1681 ± 354 1454 ± 248
LPS + HA 1992 ± 156 1465 ± 423 1143 ± 231 1210 ± 347 1576 ± 778 1291 ± 461
mPAP (mmHg) LPS + HA (sham) 23.0 ± 2.6 36.3 ± 5.6 41.3 ± 3.2 38.3 ± 5.8 38.3 ± 5.4 34.0 ± 5.1
LPS + HA 22.7 ± 0.3 37.7 ± 5.2 44.3 ± 5.2 39.3 ± 8.0 35.3 ± 7.8 31.3 ± 10
PVRI (dyn s/cm5/m2) LPS + HA (sham) 229 ± 31 477 ± 202 518 ± 181 467 ± 85 441 ± 92 343 ± 25
LPS + HA 248 ± 19 404 ± 60 499 ± 72 421 ± 156 483 ± 196 416 ± 145
PAWP (mmHg) LPS + HA (sham) 9.7 ± 2.3 12.7 ± 3.2 14.7 ± 3.0 12.0 ± 3.1 14.0 ± 4.2 13.0 ± 2.6
LPS + HA 8.3 ± 1.2 11.0 ± 1.2 16.3 ± 1.8 13.0 ± 1.7 11.0 ± 2.0 11.7 ± 3.0
EVLWI (ml/kg) LPS + HA (sham) 10.1 ± 3.5 13.1 ± 1.4 13.0 ± 0.6 15.9 ± 2.5 13.7 ± 1.0 12.9 ± 2.0
LPS + HA 8.1 ± 0.3 12.4 ± 1.8 12.5 ± 1.5 13.7 ± 1.5 13.0 ± 2.1 10.1 ± 2.3
PVPI LPS + HA (sham) 3.2 ± 1.0 4.2 ± 0.2 3.7 ± 0.5 4.4 ± 0.5 4.1 ± 0.2 4.0 ± 0.3
LPS + HA 2.5 ± 0.2 4.1 ± 0.5 3.9 ± 1.0 3.6 ± 0.3 3.1 ± 0.7 2.9 ± 0.9
  1. Hemodynamic parameters are shown in the LPS + HA (sham) and LPS + HA groups. Data are mean ± SEM, N = 3–4 of each group; CO, cardiac output; MAP, mean arterial pressure; SVRI, systemic vascular resistance index; MPAP, mean pulmonary arterial pressure; PVRI, pulmonary vascular resistance index; PAWP, pulmonary artery wedge pressure; EVLWI, extravascular lung water index; PVPI, pulmonary vascular permeability index