Table 4 Systemic and pulmonary hemodynamic measurements compared between LPS + HA (sham) and LPS + HA groups
From: Effect of HA330 resin-directed hemoadsorption on a porcine acute respiratory distress syndrome model
Parameter | Group | Time (h) | |||||
|---|---|---|---|---|---|---|---|
Baseline | T0 | 2 h | 4 h | 6 h | 8 h | ||
CO (l/min) | LPS + HA (sham) | 6.36 ± 0.41 | 5.50 ± 1.98 | 4.86 ± 1.28 | 5.35 ± 1.13 | 5.17 ± 1.10 | 5.56 ± 1.27 |
LPS + HA | 4.98 ± 0.48 | 4.99 ± 0.78 | 5.34 ± 0.94 | 6.08 ± 0.97 | 5.05 ± 0.89 | 5.15 ± 0.40 | |
MAP (mmHg) | LPS + HA (sham) | 125 ± 6 | 82 ± 3 | 92 ± 20 | 106 ± 21 | 104 ± 25 | 96 ± 24 |
LPS + HA | 118 ± 7 | 85 ± 15 | 74 ± 9 | 86 ± 12 | 82 ± 17 | 80 ± 16 | |
SVRI (dyn s/cm5/m2) | LPS + HA (sham) | 1699 ± 59 | 1120 ± 154 | 1813 ± 688 | 1788 ± 468 | 1681 ± 354 | 1454 ± 248 |
LPS + HA | 1992 ± 156 | 1465 ± 423 | 1143 ± 231 | 1210 ± 347 | 1576 ± 778 | 1291 ± 461 | |
mPAP (mmHg) | LPS + HA (sham) | 23.0 ± 2.6 | 36.3 ± 5.6 | 41.3 ± 3.2 | 38.3 ± 5.8 | 38.3 ± 5.4 | 34.0 ± 5.1 |
LPS + HA | 22.7 ± 0.3 | 37.7 ± 5.2 | 44.3 ± 5.2 | 39.3 ± 8.0 | 35.3 ± 7.8 | 31.3 ± 10 | |
PVRI (dyn s/cm5/m2) | LPS + HA (sham) | 229 ± 31 | 477 ± 202 | 518 ± 181 | 467 ± 85 | 441 ± 92 | 343 ± 25 |
LPS + HA | 248 ± 19 | 404 ± 60 | 499 ± 72 | 421 ± 156 | 483 ± 196 | 416 ± 145 | |
PAWP (mmHg) | LPS + HA (sham) | 9.7 ± 2.3 | 12.7 ± 3.2 | 14.7 ± 3.0 | 12.0 ± 3.1 | 14.0 ± 4.2 | 13.0 ± 2.6 |
LPS + HA | 8.3 ± 1.2 | 11.0 ± 1.2 | 16.3 ± 1.8 | 13.0 ± 1.7 | 11.0 ± 2.0 | 11.7 ± 3.0 | |
EVLWI (ml/kg) | LPS + HA (sham) | 10.1 ± 3.5 | 13.1 ± 1.4 | 13.0 ± 0.6 | 15.9 ± 2.5 | 13.7 ± 1.0 | 12.9 ± 2.0 |
LPS + HA | 8.1 ± 0.3 | 12.4 ± 1.8 | 12.5 ± 1.5 | 13.7 ± 1.5 | 13.0 ± 2.1 | 10.1 ± 2.3 | |
PVPI | LPS + HA (sham) | 3.2 ± 1.0 | 4.2 ± 0.2 | 3.7 ± 0.5 | 4.4 ± 0.5 | 4.1 ± 0.2 | 4.0 ± 0.3 |
LPS + HA | 2.5 ± 0.2 | 4.1 ± 0.5 | 3.9 ± 1.0 | 3.6 ± 0.3 | 3.1 ± 0.7 | 2.9 ± 0.9 | |