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Annals of Intensive Care

Table 1 Neurophysiological data

From: Early impairment of intracranial conduction time predicts mortality in deeply sedated critically ill patients: a prospective observational pilot study

Evoked potentials data

Healthy control subjects (n = 20)

Deeply sedated critically ill patients (n = 86)

Mean latency ± SD (in ms)

Mean latency + 2.5 SD (in ms)

Mean latency ± SD (in ms)

Delayed latency n (%)

SSEP components

 N9 PL

9.8 ± 0.6

11.4

11.0 ± 1.6

33 (38)

 N13 PL

13.2 ± 0.8

15.2

14.9 ± 2.1

36 (42)

 P14 PL

14.6 ± 0.9

16.8

16.2 ± 2.0

32 (37)

 N20 PLa

18.8 ± 1.0

21.4

21.6 ± 2.6

41 (48)

 N9-N13 IPL

3.4 ± 0.4

4.4

3.9 ± 0.9

14 (16)

 P14-N20 IPLa

(ICCT)

4.1 ± 0.5

5.3

5.3 ± 1.5

39 (45)

BAEP components

 Wave I PL

1.5 ± 0.2

2.0

1.69 (0.31)

13 (15)

 Wave III PL

3.6 ± 0.2

4.1

3.96 (0.35)

34 (40)

 Wave V PL

5.6 ± 0.3

6.3

6.16 (0.61)

34 (40)

 I–III IPL

2.1 ± 0.2

2.6

2.28 (0.29)

17 (20)

 III–V IPL (IPCT)

2.0 ± 0.2

2.5

2.20 (0.45)

15 (17)

 I–V IPL

4.1 ± 0.3

4.8

4.51 (0.59)

17 (20)

  1. PL peak latency, IPL inter-peak latency, ICCT intracranial conduction time, IPCT intra- pontine conduction time. PL and IPL of SSEP or BAEP’s components were scored as “delayed” when they were greater than the “mean + 2.5 SD” of the ones of a healthy control group
  2. aN20 was abolished in three patients. N20 PL and P14-N20 IPL were consequently considered as delayed for these 3 patients with abolished N20. Median nerve somatosensory evoked potentials (SSEP) and brainstem auditory evoked potentials (BAEP) components latencies (PL) and inter-peak latencies (IPL) obtained from a group of 20 healthy control subjects (11 women, 9 men, mean age 51 ± 17 years) in our laboratory; and from 86 deeply sedated critically ill patients. Each variable is represented by the mean values of left and right hand sides
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