How to reduce cisatracurium consumption in ARDS patients: the TOF-ARDS study

Annals of Intensive Care

Table 4 Multivariate analysis evaluating the factors associated with increase(s) in cisatracurium dosage

Variables	Odds ratio	95% CI	p value
First model with PEEP at day 1
Weight, per 1 kg increase	1.14	0.98–1.31	0.07
Bicarbonates, per 1 mmol/L	1.06	0.87–1.29	0.56
PEEP day 1, per 1 cm H₂O increase	0.42	0.18–0.98	0.044
Severe ARDS	0.22	0.017–2.89	0.25
Use of prone position	1.73	0.14–22.06	0.67
Other organ failure, per organ	6.02	0.68–53.1	0.10
Second model with driving pressure at day 1
Weight, per 1 kg increase	1.07	0.99–1.16	0.065
Bicarbonates, per 1 mmol/L	1.06	0.87–1.29	0.58
Driving pressure day 1, per 1 cm H₂O increase	1.99	1.01–3.9	0.045
Severe ARDS	0.32	0.017–6.02	0.44
Use of prone position	6.98	0.32–153.4	0.22
Other organ failure, per organ	1.96	0.35–10.85	0.44

ARDS Acute Respiratory Distress Syndrome, PEEP positive end-expiratory pressure