Validation of transpulmonary thermodilution variables in hemodynamically stable patients with heart diseases

Annals of Intensive Care

Table 1 Patient characteristics

	Control n = 11	AS n = 10	DCM n = 8	p
Age [a]	62 ± 7	78 ± 11^a	56 ± 14^b	<0.001
Sex (male)	9/11	7/10	7/8	0.64
BSA predicted [m²]	1.80 ± 0.15	1.74 ± 0.16	1.82 ± 0.11	0.46
NYHA class [1]	1.5 ± 0.5	2.4 ± 0.7	2.0 ± 1.2	0.07
Hb [g l⁻¹]	139 ± 18	133 ± 9	132 ± 15	0.51
Lactate [mmol l⁻¹]	0.8 ± 0.3	0.5 ± 0.2	0.9 ± 0.3^b	0.02
N-terminal B-type natriuretic peptide [ng l⁻¹]	177 ± 216	882 ± 994	1423 ± 1132^a	0.01
Echocardiography, left ventricle (LV)
LV end-diastolic volume [ml]	98 ± 35	97 ± 21	181 ± 25^ab	<0.0001
LV myocardial mass index [g m⁻²]	96 ± 16	116 ± 21^a	145 ± 19^ab	<0.001
LV ejection fraction [%]	64 ± 7	60 ± 13	32 ± 9^ab	<0.0001
E/e′ ratio [1]	9.4 ± 3.3	12.0 ± 2.3	11.0 ± 3.4^(*)	0.21
Echocardiography, right ventricle (RV)
RV transversal diameter (D2) [mm]	27 ± 6	26 ± 5	29 ± 11	0.73
RV longitudinal diameter (D3) [mm]	68 ± 5	66 ± 10	78 ± 12^b	0.04
Tricuspid annular plane systolic excursion [mm]	23 ± 4	23 ± 6	19 ± 5	0.23
RV fractional area change [%]	47 ± 11	52 ± 12	50 ± 17	0.74
Echocardiography, aortic valve
Aortic valve area [mm²]	3.0 ± 1.5	1.0 ± 0.4^a	2.5 ± 0.4^b	<0.0001
Aortic valve peak instantaneous pressure gradient [mmHg]	3.8 ± 3.4	48.9 ± 26.2^a	5.4 ± 2.2^b	<0.0001
Aortic valve mean pressure gradient [mmHg]	2.3 ± 2.1	26.2 ± 17.8^a	3.4 ± 1.2^b	<0.001
Echocardiography, mitral valve
Secondary, moderate-to-severe mitral regurgitation	0/11	0/10	3/8	0.07

Values are given as mean ± SD. Pairwise analysis is represented by^a,b where p < 0.05 versus the control and AS groups, respectively. ^(*) n = 5 for E/e′ ratio reported in the DCM group, since E/e′ ratio measurements were discarded in patients with moderate-to-severe mitral regurgitation
AS aortic valve stenosis, DCM dilated cardiomyopathy, BSA body surface area, NYHA New York Heart Association functional classification of heart failure, Hb hemoglobin