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Table 4 Summary of subgroup analysis of the included studies by the potentially influencing variables

From: Comparison of diagnostic accuracy in sepsis between presepsin, procalcitonin, and C-reactive protein: a systematic review and meta-analysis

Variable Category Number of studies Number of patients Pooled sensitivity Pooled specificity
Asian country Yes 8 2091 0.81 (0.76–0.86) 0.82 (0.78–0.85)
No 10 1379 0.86 (0.80–0.90) 0.70 (0.54–0.83)
Patients admitted in ICU Yes 8 783 0.86 (0.80–0.90) 0.64 (0.51–0.76)
No 10 2687 0.83 (0.76–0.89) 0.82 (0.73–0.88)
Whole blood specimen Yes 6 1942 0.83 (0.73–0.88) 0.82 (0.78–0.86)
No 12 1528 0.84 (0.79–0.89) 0.71 (0.58–0.82)
Sample sizes great than 150 Yes 6 2215 0.78 (0.72–0.83) 0.77 (0.68–0.84)
No 12 1255 0.87 (0.82–0.90) 0.75 (0.62–0.84)
Proportions of patients with sepsis great than 0.5 Yes 14 2802 0.84 (0.80–0.88) 0.72 (0.63–0.79)
No 4 668 0.85 (0.55–0.96) 0.86 (0.63–0.95)
Cut-off value great than 700 Yes 4 642 0.85 (0.70–0.93) 0.59 (0.37–0.78)
No 14 2828 0.84 (0.79–0.87) 0.80 (0.72–0.85)