Table 6 Summary diagnostic accuracy of the included studies for biomarkers, presepsin, procalcitonin, and C-reactive protein
References | Sepsis/control (n) | Presepsin | Procalcitonin | C-reactive protein | ||||||
|---|---|---|---|---|---|---|---|---|---|---|
Sensitivity | Specificity | AUC | Sensitivity | Specificity | AUC | Sensitivity | Specificity | AUC | ||
Shozushima et al. [17] | 101/41 | 0.80 | 0.81 | 0.88 | – | – | 0.65 | – | – | 0.82 |
Endo et al. [29] | 115/70 | 0.88 | 0.81 | 0.91 | 0.86 | 0.79 | 0.91 | – | – | – |
Liu et al. [33] | 680/279 | 0.71 | 0.86 | 0.82 | 0.60 | 0.78 | 0.72 | – | – | – |
Ulla et al. [38] | 106/83 | 0.79 | 0.62 | 0.70 | 0.89 | 0.76 | 0.88 | – | – | – |
Vodnik et al. [39] | 30/100 | 1 | 0.98 | 0.99 | 0.87 | 0.97 | 0.96 | – | – | 0.96 |
Behnes et al. [25] | 81/15 | 0.90 | 0.60 | 0.84 | – | – | 0.86 | – | – | – |
Brenner et al. [26] | 60/60 | 0.91 | 0.67 | 0.83 | 0.77 | 0.78 | 0.84 | 0.67 | 0.85 | 0.79 |
Romualdo et al. [35] | 37/189 | 0.81 | 0.63 | 0.75 | 0.76 | 0.64 | 0.79 | 0.62 | 0.52 | 0.60 |
Ishikura et al. [31] | 43/39 | 0.93 | 0.76 | 0.89 | – | – | – | – | – | – |
Kweon et al. [32] | 73/45 | 0.88 | 0.82 | 0.94 | 0.86 | 0.87 | 0.92 | 0.99 | 0.67 | 0.85 |
Cakir Madenci et al. [27] | 26/11 | 0.77 | 0.76 | 0.83 | 0.76 | 0.79 | 0.85 | 0.92 | 0.58 | 0.82 |
Nakamura et al. [34] | 37/75 | 0.70 | 0.81 | 0.78 | – | – | – | – | – | – |
Sargentini et al. [36] | 60/44 | 0.86 | 0.72 | 0.89 | 0.80 | 0.80 | 0.91 | – | – | – |
Godnic et al. [30] | 40/7 | 0.85 | 0.63 | 0.71 | 0.58 | 0.67 | 0.63 | 0.77 | 0.75 | 0.73 |
Takahashi et al. [37] | 359/97 | 0.80 | 0.83 | 0.89 | 0.77 | 0.76 | 0.85 | 0.72 | 0.95 | 0.82 |
Carpio et al. [28] | 114/9 | 0.81 | 0.75 | 0.83 | – | – | – | – | – | – |
Kada Klouche et al. [41] | 100/44 | 0.90 | 0.55 | 0.75 | 0.80 | 0.59 | 0.80 | – | – | – |
Romualdo et al. [40] | 70/130 | 0.67 | 0.81 | 0.78 | 0.67 | 0.84 | 0.82 | 0.26 | 0.92 | 0.59 |