Skip to main content
Annals of Intensive Care

Table 3 Population characteristics depending on different cut-offs of [TIMP-2]·[IGFBP7] index for AKI diagnose

From: Cell-cycle arrest biomarkers in urine to predict acute kidney injury in septic and non-septic critically ill patients

 

Worst [TIMP-2]·[IGFBP7] index within the first 12 h in ((ng/mL)2/1000)

≤0.3

0.31–2

>2

p value

≤0.4

0.41–0.8

>0.8

p value

n

38

40

20

–

47

16

35

–

Men (n = 65)

21 (55.3%)

30 (75%)

14 (70%)

NS

29 (61.7%)

12 (75%)

24 (68.6%)

NS

Age (years)

53 ± 18.4

54 ± 16.7

62 ± 15

NS

52 ± 18.5

52 ± 18.4

61 ± 13.7

0.043

Renal characteristics

 Baseline creatinine (μmol/L)

84 ± 31.9

72 ± 28.5

85 ± 34.9

NS

83 ± 30.1

66 ± 33.3

80 ± 32

NS

 Baseline eGFR (mL/min) n = 86

117 ± 60.1 (n = 31)

123 ± 48.1 (n = 35)

79 ± 40.9 (n = 20)

0.008

112 ± 55.4 (n = 39)

128 ± 54.1 (n = 12)

103 ± 52.7 (n = 35)

NS

 AKI while in ICU (n = 49)

9 (23.7%)

22 (55%)

18 (90%)

<0.001

13 (27.7%)

8 (50%)

28 (80%)

<0.001

 AKIN ≥ 2 while in ICU (n = 31)

4 (10.5%)

13 (32.5%)

14 (70%)

<0.001

6 (12.8%)

3 (18.8%)

22 (62.9%)

<0.001

 RRT <48 h (n = 5)

0 (0%)

3 (7.5%)

2 (10%)

NS

0 (0%)

0 (0%)

5 (14.3%)

0.007

ICU epidemiological data

 Sepsis at admission (n = 40)

11 (29%)

18 (45%)

11 (55%)

NS

16 (34%)

8 (50%)

16 (45.7%)

NS

 Shock (n = 35)

11 (29%)

12 (30%)

12 (60%)

0.039

13 (27.7%)

4 (25%)

18 (51.4%)

0.053

 Mechanical ventilation (n = 79)

32 (84.2%)

32 (80%)

15 (75%)

NS

39 (83%)

13 (81.3%)

27 (77.1%)

NS

 SAPS II

35 ± 15.4

34 ± 17.4

49 ± 21.1

0.004

35 ± 16.2

28 ± 11.9

44 ± 21.1

0.006

 APACHE II

16 ± 8.7

15 ± 7.5

17 ± 8.8

NS

15 ± 8.2

13 ± 6.0

18 ± 8.8

NS

 SOFA at ICU admission

7 ± 3.5

7 ± 3.9

8 ± 3.8

NS

7 ± 3.8

7 ± 3.7

8 ± 3.5

NS

 ICU LOS

8.6 ± 9.1

15.6 ± 20.1

7.0 ± 5.3

0.036

8.8 ± 8.7

12.6 ± 15.8

13.6 ± 19.6

NS

 Hospital LOS

24.6 ± 25.9

24.9 ± 28.9

19.2 ± 12.5

NS

23.6 ± 24.9

20.8 ± 16.1

24.9 ± 28.7

NS

 ICU mortality (n = 10)

4 (10.5%)

4 (10%)

2 (10%)

NS

4 (8.5%)

1 (6.3%)

5 (14.3%)

NS

  1. Values expressed as either % of cases per row or mean ± standard deviation. p value of statistical significance
  2. In our database, five patients had a much longer length of stay (51, 53, 60, 68 and 97 days) than the overall group (≤30 days). Four of these five patients presented index values 0.31–2 ((ng/mL)2/1000), which may explain this finding
  3. NS no statistical significance, AKI acute kidney injury, AKIN acute kidney injury network definition, APACHE II acute physiology and chronic health evaluation II, ICU intensive care unit, LOS length of stay, SAPS II Simplified Acute Physiology Score II, SOFA sequential organ failure assessment score
Back to article page