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Table 3 Population characteristics depending on different cut-offs of [TIMP-2]·[IGFBP7] index for AKI diagnose

From: Cell-cycle arrest biomarkers in urine to predict acute kidney injury in septic and non-septic critically ill patients

  Worst [TIMP-2]·[IGFBP7] index within the first 12 h in ((ng/mL)2/1000)
≤0.3 0.31–2 >2 p value ≤0.4 0.41–0.8 >0.8 p value
n 38 40 20 47 16 35
Men (n = 65) 21 (55.3%) 30 (75%) 14 (70%) NS 29 (61.7%) 12 (75%) 24 (68.6%) NS
Age (years) 53 ± 18.4 54 ± 16.7 62 ± 15 NS 52 ± 18.5 52 ± 18.4 61 ± 13.7 0.043
Renal characteristics
 Baseline creatinine (μmol/L) 84 ± 31.9 72 ± 28.5 85 ± 34.9 NS 83 ± 30.1 66 ± 33.3 80 ± 32 NS
 Baseline eGFR (mL/min) n = 86 117 ± 60.1 (n = 31) 123 ± 48.1 (n = 35) 79 ± 40.9 (n = 20) 0.008 112 ± 55.4 (n = 39) 128 ± 54.1 (n = 12) 103 ± 52.7 (n = 35) NS
 AKI while in ICU (n = 49) 9 (23.7%) 22 (55%) 18 (90%) <0.001 13 (27.7%) 8 (50%) 28 (80%) <0.001
 AKIN ≥ 2 while in ICU (n = 31) 4 (10.5%) 13 (32.5%) 14 (70%) <0.001 6 (12.8%) 3 (18.8%) 22 (62.9%) <0.001
 RRT <48 h (n = 5) 0 (0%) 3 (7.5%) 2 (10%) NS 0 (0%) 0 (0%) 5 (14.3%) 0.007
ICU epidemiological data
 Sepsis at admission (n = 40) 11 (29%) 18 (45%) 11 (55%) NS 16 (34%) 8 (50%) 16 (45.7%) NS
 Shock (n = 35) 11 (29%) 12 (30%) 12 (60%) 0.039 13 (27.7%) 4 (25%) 18 (51.4%) 0.053
 Mechanical ventilation (n = 79) 32 (84.2%) 32 (80%) 15 (75%) NS 39 (83%) 13 (81.3%) 27 (77.1%) NS
 SAPS II 35 ± 15.4 34 ± 17.4 49 ± 21.1 0.004 35 ± 16.2 28 ± 11.9 44 ± 21.1 0.006
 APACHE II 16 ± 8.7 15 ± 7.5 17 ± 8.8 NS 15 ± 8.2 13 ± 6.0 18 ± 8.8 NS
 SOFA at ICU admission 7 ± 3.5 7 ± 3.9 8 ± 3.8 NS 7 ± 3.8 7 ± 3.7 8 ± 3.5 NS
 ICU LOS 8.6 ± 9.1 15.6 ± 20.1 7.0 ± 5.3 0.036 8.8 ± 8.7 12.6 ± 15.8 13.6 ± 19.6 NS
 Hospital LOS 24.6 ± 25.9 24.9 ± 28.9 19.2 ± 12.5 NS 23.6 ± 24.9 20.8 ± 16.1 24.9 ± 28.7 NS
 ICU mortality (n = 10) 4 (10.5%) 4 (10%) 2 (10%) NS 4 (8.5%) 1 (6.3%) 5 (14.3%) NS
  1. Values expressed as either % of cases per row or mean ± standard deviation. p value of statistical significance
  2. In our database, five patients had a much longer length of stay (51, 53, 60, 68 and 97 days) than the overall group (≤30 days). Four of these five patients presented index values 0.31–2 ((ng/mL)2/1000), which may explain this finding
  3. NS no statistical significance, AKI acute kidney injury, AKIN acute kidney injury network definition, APACHE II acute physiology and chronic health evaluation II, ICU intensive care unit, LOS length of stay, SAPS II Simplified Acute Physiology Score II, SOFA sequential organ failure assessment score