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Annals of Intensive Care

Table 4 Diagnostic and overall accuracy of [TIMP-2]·[IGFBP7] for AKI compared with gold standard AKIN classification

From: Cell-cycle arrest biomarkers in urine to predict acute kidney injury in septic and non-septic critically ill patients

[TIMP-2]·[IGFBP7] cut-off value ((ng/mL)2/1000)

Se %

95% CI

Sp %

95% CI

AUC

95% CI

0.3—to predict AKI

81.6

78.2–85.0

59.2

54.9–63.5

0.80

0.71–0.89

0.4—to predict AKI

73.5

69.7–77.5

71.4

67.4–75.4

  

0.8—to predict AKIN ≥ 2

72.0

68.1–75.9

78.1

74.6–81.8

0.81

0.70–0.91

2.0—to predict AKIN ≥ 2

48.0

43.6–52.4

90.4

87.8–93.0

  
  1. AUC area under curve of ROC analysis; CI confidence interval; Se sensitivity; Sp specificity
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